I lymphoid cell line inosanganisira iyo masero eropa anotanga mufupa remapfupa muitiro inonzi hematopoiesis, uye inobva kune imwechete lymphoid stem cell.
Hematopoiesis
Kubudiswa kwe "masero eropa" ose kunotanga mumapfupa emapfupa muchiito chinonzi hematopoiesis . Muchiitiko ichi, marudzi ose emasero eropa anobva pane hematopoietic stem cell .
Iyi sero yepakutanga, iyo inonziwo "multipotent stem cell", inogona kufananidzwa naAdhamu mubhuku reBhaibheri, se "baba seyero" kubva kune dzimwe dzose masero eropa anobudiswa. Aya masero anonziwo pluripotent stems cells, zvinoreva kuti vane simba rekuve nemhando dzakasiyana dzemasero.
Nzvimbo yekutanga yemasero inoitika apo iyi pluripotent seyero inotevera imwe yenzira mbiri dzekufambisa dzinonzi cell lines. Iyo pluripotent stem cell inogona kusiyanisa mune imwe myeloid cell line kana lymphoid cell line.
Lymphoid Stem Cell - Lymphoblast
Lymphoid cell line inotanga ne lymphoid stem cell, inozivikanwa se lymphoblast kana lymphoid progenitor cell. Iyi iforogo huru mumugwagwa sezvo masero ose ari mumutsara uyu anotanga ne lymphoid progenitor cell, asi masero ose ari mumutezo wemamiyoidhi (akadai neutrophils, macrophages, uye masero matsvuku eropa) anotanga ne myeloid progenitor cell.
Lymphoid Cell Line Cells
I-lymphoid progenitor cell (lymphoblast) inogona kuwedzera kusiyanisa mberi mune imwe yakawanda mumasero inosanganisira:
- B lymphocytes - B lymphocytes kana "B masero anoshanda kudzivirira muviri wako kubva kune hutachiona nekuita zvirwere.
- T lymphocytes - T lymphocytes, kana kuti "T masero" ndiwo masero muzvirwere zvemuviri zvinowana, kuuraya, uye kuronga hondo yezvimwe zvinhu zvakadai semabhakitiriya, mavairasi, uye kenza masero.
- Muurayi wechipfuva - Masero ehupenyu anouraya masero ane utsinye emuviri wechirwere chemuviri anoita kubvisa masero emukenza uye masero ane utachiona.
Lymphoid Cell Line uye Immunity
Lymphoid lineage masero inoumba anenge 15% emasero mune hutano husina marara. Hematopoietic stem masero ari kuramba achiparadzanisa mu lymphoid progenitor cells izvo zvinoramba zvichiparadzaniswa mumasero akakura anogadzira lymphoid cell line. Inofungidzirwa kuti marora emapfupa anotendeuka masero emamiriyoni makumi maviri emagazi eropa paawa.
Lymphoid Malignancies
Cancers inosanganisira masero mumutsara we lymphoid unosanganisira:
- Non-Hodgkin lymphomas - I-non-Hodgkin lymphomas inoumba yeboka rakasiyana-siyana remymphomas rinogona kusanganisira ma B seli kana T cells. Izvozvo zvinokonzerwa nekenza zvinoratidzirwa mune gumi zvinokonzera kukonzerwa nekenza nekuda kwevarume nevakadzi.
- Hodgkin lymphomas - Hodgkin lymphomas inowanzonyoresa kanzira, uye iye zvino ndiyo inonyanyozivikanwa nekenza inowanikwa kune vechidiki vari pakati pemakore gumi nemashanu ne25.
- Acute lymphocytic leukemia (ALL) - Acute lymphocytic leukemia ndiyo kenza inosanganisira lymphoblasts - masero anoenderera kuva B masero, masero eT, uye maseru ekuuraya. Izvo zvinowanzoonekwa kune vana vasati vava nemakore gumi asi zvinogona kuitika chero ipi zvayo.
- Chronic lymphocytic leukemia (CLL) - Chronic lymphocytic leukemia ikenza iyo muUnited States inobata zvikuru B lymphocytes. T chechi CLL, zvakasiyana, inonyanya kuwanikwa mune dzimwe nzvimbo dzeJapan.
Sources:
> Liu, A., Wang, Y., Ding, Y. et al. Kugadzirisa Edge: Hematopoietic Stem Kuwedzera Kwemajeri uye Kazhinji Lymphoid Progenitor Kudzingwa Kunoda Hematopoietic-Akaitwa, Cell-Autonomous TLR4 muMuenzaniso Wekupedzisira Endotoxin. Journal of Immunology . 2015. 196 (6): 2524-8.
Sieff, C. Kubwinya kwehematopoiesis uye stem cell function. Kusvika pari zvino. Updated 05/26/15. http://www.uptodate.com/contents/overview-of-hematopoiesis-and-stem-cell-function
Liang, H., uye J. Zuniga-Pflucker. Hematopoiesis: Kubva kutanga kusvika ku immune reconstitution potential. Cell Cell Stem Research & Therapy . 2015. DOI: 10.1186 / s13287-015-0051-z