Mast masero masero anowanikwa muhutano hunobatanidza mukati memiviri yedu sechikamu chemuviri wedu wesimba. Mast masero anonyanya kuzivikanwa mumatumbu emitumbi yedu iyo inobatanidza nenyika yedu yekunze, yakadai seyei inowanikwa paganda redu uye mumapepa edu ekufema uye ekudya . Mast masero anogonawo kuwanika muzvikamu uye zvisikwa zvehurongwa hwedu hwepakati uye hwekutya.
Mast cells anoita basa rinokosha pakudzivirira hutano hwedu nekupa mutsara wezvidziviriro pamusoro pezvirwere .
Mast Cell Functions
Mukupindurwa nekusvibiswa kune pathogen inonzwisisika, mast masero anogadzirisa kupindura kwekurumidza kuvhiringidzi kune kunze kwevavengi, zvakadai semishonga, mavairasi, uye zvipembenene. Mast masero ane simba rekuuraya zvakananga izvi zvipenyu kana kuti kukurudzira kugadzirwa nekubudiswa kwezvinhu zvinoparadza pathogen.
Mast cells anoshandisa basa rakakurumbira mukugadziriswa kwemaitiro evanhu. Apo munhu ane zvirwere, mamasi masero ari kupindura kune zvinokuvadza zvinokonzera sokunge zvaive pangozi.
Mukuwedzera kune kudzivirira kwavo uye maitiro ezvirwere zvezvirwere zvinokonzerwa nemasikirwo, mast masero anobatanidzwawo mune:
- Homeostasis yemidziyo yeropa uye maronchial functioning
- Kukuvadza kuporesa
- Kuumba mishonga yeropa idzva
- Chengetedza kushanda kwemasero mumuviri wose
- Mutemo wefupa kukura
Mast Cell Response
Mukupindura kune chinonzi chaityisidzirwa, mast cells anosunungura kusununguka kwemarudzi akasiyana-siyana evaridzi vehurumende, sa histamine uye serotonin, uye enzyme dzakadai se cytokines uye proteases.
Izvi zvinokonzera mhinduro mbiri uye dzinogara kwenguva refu yekuputira. Ngatitarisei zvimwe zvezvakawanda zvinowanikwa mast cell answer.
Gestrointestinal tract response
Apo patinodya chimwe chinhu chinonzwisisika kuva chakaipa, mast masero anotanga mhinduro ine zvinotevera zvinoguma:
- Kuwedzererwa kwemvura kusvibiswa
- Kuwedzera mushure mutsva mukati mekugadzira muviri (zvinogona kukonzera kurutsira kana chirwere)
- Endesa nyaya yepamusoro faster nokukurumidza kuburikidza nekoloni
Izvi zviito zvinonzwisisa, handizvo here? Muviri uri kuedza kubvisa izvo zvaunoona zvichikuvadza nokukurumidza sezvazvinokwanisa.
Mast masero anotamba basa rinokosha mukusimudzira hutano hwakanaka hwebhakitiriya hunoita maruva edu . Sezvo masi masero anowanikwa mukati mechidzitiro chemukati wedu, vanoita basa mukuparadza nekudzivirira miviri yedu kubva kune mabhakitiriya emagetsi.
Kufuridzirwa kwemashoko anopindura
Mast masero anowanikwa munzvimbo yose yemakamuri edu ekufema. Mukupindura kune antigen, kazhinji iyo inoputika, mast masero anotanga mhinduro dzekuzvidzivirira mumuviri dzinosanganisira:
- Kusagadzikana kwemhepo yedu
- Kusungwa
- Kuchema
- Kuwedzera kwekugadzirwa kwemasukisi
Sezvaunogona kuona kubva pamigumisiro yepamusoro, hazvishamisi kuti masi masero anonyanyobatanidzwa muzviratidzo zveanorighema asthma .
Kugadziriswa kweganda
Iwe unogona kunge uchiziva nepfungwa yokuti vamwe vanhu vanoona mikoko kana kuti kukurumidza mukupindura kudya imwe zvokudya. Izvi zvinoitika nokuti maantigen muzvokudya anopinda muropa kuburikidza neTI yeTI. Sezvavanenge vachifamba nomumumuviri vanosangana nemasero emuviri anowanikwa mumatumbu eganda.
Mhinduro yekuvhiringidzika kweiyi mast cells inogona kuguma nekuputika, mikoko, rashes uye chinetso chisingaverengeki che atopic dermatitis (eczema).
Mast Cells uye Digestive Disease
Pamusana pekuti masi masero anoisa maronda emukati, uye anopa migumisiro yavo maererano nemagadzirirwo ezvirwere zvekuzvidzivirira pamuviri, mast masendi akave akabatanidzwa pakuita basa mune zvinotevera zvirwere zviviri zvepamuviri:
Migumisiro yemasero mashoma anogona kuguma mune zviratidzo zvinotevera:
- Kufamba nokukurumidza kwechigaro (zvinoita kuti muve nehara)
- Kuwedzererwa kwemvura mumakumbo makuru (uyewo kunopa kubudisa chirwere)
Zvinofadza, zviito zvemashure mashoma zvinogona kutungamirirwa nehuwandu hwekutambudzika uri pasi. Ikoko kunoratidzika kuva nenzira mbiri yekukurukurirana pakati pemasero emagetsi ako emagetsi uye mast cells. Nokudaro zviito zvemashure mashoma anogona kuita basa rinokosha mukuti zviratidzo zveBS zvinogona kukuvadzwa nekunze kwekunetseka.
Zvidzidzo zvakaratidza kuti pane kuwedzera kwenhamba yemasero mumakumbo emubhedha wevanhu vane IBS. Masayendisiti haasati aziva zvakawanda pamusoro pokuti nei zvakadaro, asi inzvimbo inofadza yekutsvakurudza sezvo inotungamirira kune mukana wekuvandudzwa kwemishonga inobudirira yehutano.
Sources:
Krystel-Whittemore, M. "Mast Cell: Multi-Functional Master Cell" Mitsara mu Immunology 2015 6: 620.
Philpott, H., Gibson, P. & Thien, F. "Irritable bowel syndrome - Chirwere chinoputika chinosanganisira mast cells" Asia Pacific Allergy 2011 1: 36-42.
Ramsay, D., uye. al. "Mast Cells in Gastrointestinal Disease" Gastroenterology & Hepatology 2010 6: 772-777.
Urb, M. & Sheppard, D. "Basa reMasera Mashoma Mukudzivirirwa Nezvirwere Zvitachiona" PLoS Pathogens 2012 8: e1002619.