Sezvo masero eropa achikura, "mhuri" dzakasiyana dzinobuda kubva kuropa-kuumba masero emadzi. Iyo myeloid cell line inomirira imwe mhuri yakadaro. Maseji ari myeloid cell line ndeaya anobva mumamirojeni anonzi myeloid progenitor, uye pakupedzisira achava masero evanhu vakuru vane ropa, anoratidzwa pano:
- Basophils
- Neutrophils
- Eosinophils
- Monocytes (iripo muropa)
- Macrophages (iripo mumasikisi akasiyana)
- Erythrocytes (masero matsvuku eropa)
Nokudaro, imwe neimwe yesero yemhando iri pamusoro inomiririra chigumo chekupedzisira kana mugumisiro wekukura mumhuri myeloid.
Ndiyo myeloid cell line iyo inobata "myeloid malignancies" yakadai seyakanyanya myelogenous leukemia (AML) , iyo inonyanya kuwanda yezviongororwo gore rimwe nerimwe, uye isingaperi myelogenous leukemia (CML) , iyo inobata anenge 6 660 mitsva yekuongorora mune imwe gore muUnited States.
Context
Masero matsvuku , masero machena, uye maplatelets ose akaisa mararamiro ehupenyu, uye anotsiviwa achienderera mberi. Ropa-kuumba masero emasero - anogara kakawanda mumufupa wevanhu mune vanhu vakuru - kuwedzera uye kubereka vanhu vakasiyana, kana mitsara yemasero.
Mamwe masero eropa akakura anogona kutevera dzinza ravo kumashure rimwe chete, iyo inonzi multipotent hematopoietic stem cell (HSC), chimwe chinhu chakafanana ne "Adhamu naEvha" yemasero ose eropa.
Aya masero emadzimai akaparadzanisa - zvose kuti azvitsigire ivo uye kuti aumbe "masero emasero." Pakati pezvizvarwa zveHSC, zvino, marudzi akasiyana emasero emasero: pane lymphoid progenitor anozivikanwa uye anowanzoita myeloid progenitor. Iyi mahwindo mumugwagwa pakati pe lymphoid uye myeloid mitsara inokosha.
Mutungamiri mumwe nomumwe anokwanisa kupa mapoka emhuri yake yakasiyana yemasero eropa. Maseu akachena eropa anozivikanwa se lymphocytes anowanzobva kune lymphoid progenitors, asi masero matsvuku eropa, masero matsvuku eropa uye maplatelet anobudirira kubva kumamera emeteidhi. Mitsara ye myeloid line inowanzoita anenge 85% yemasero masero, akazara.
Myeloid Malignancies
Maererano neAmerican Cancer Society, vakawanda varwere vane myeloid yeukemia yakaoma (AML) vane dzakawanda masero masero matsvene muropa ravo, uye kwete masero matsvuku eropa kana maplatelet. Mazhinji emasero matsvuku eropa anogona kunge ari myeloblasts - kazhinji anonzi mavhiri - ayo ari masero eropa-forming masero asingawanzowanikwi muropa rinopararira. Izvi masero masero haashande sezvakajairika, masero matsvuku eropa.
Vakawanda vanorwara vane myeloid yeukemia isingagumi (CML) vane masero akawanda emachena eropa ane akawanda akawanda, masero masero. Mamwe aya masero machena asingasviki anogona kunge ariwo anoputika asi kazhinji anowanikwa mune zvishoma kudarika mu AML. Dzimwe nguva CML varwere vangavewo vane nhamba dzakaderera dzemasero matsvuku eropa kana maplatelet eropa.
Mune zvose AML uye CML, nhamba dzemazipa eropa dzinogona kuva nehupenzi hwehutachiona, asi kugadziriswa kwechokwadi kunoda bone marrow biopsy uye aspirate nezvimwe zviedzo.
Sources
Krumsiek J, Marr C, Schroeder T, et al. Kusiyana kweHerarchical yeMyeloid Progenitors Inonyorwa muTricription Factor Network. PLoS One. 2011; 6 (8): e22649.
Eaves CJ. Hematopoietic stem masero: pfungwa, tsanangudzo, uye chokwadi chitsva. Ropa . 2015; 125 (17): 2605-2613.
Orkin SH, Zon LI. Hematopoiesis: An Evolving Paradigm yeStem Cell Biology. Cell . 2008; 132 (4): 631-644.
Jagannathan-Bogdan M, Zon LI. Hematopoiesis. Kubudirira (Cambridge, England) . 2013; 140 (12): 2463-2467.
American Cancer Society. Ndeipi inonzi acute myeloid leukemia inowanikwa? Yakasvika muna December 2015.
Williams, L. "Kuongorora kwakakwana kweHematopoiesis uye Immunology: Zvinokonzerwa neHematopoietic Stem Cell Transplant Acceptors" muEzzone, S. (2004) Hematopoietic Stem Cell Transplantation: Bhuku Rekuchengetedza Maitiro Oncology Inobatsira Vamukoti: Pittsburgh, PA (pp.1- 12).