Kusiyana nedzimwe kenza, hazvizivikanwi izvo zvinokonzera kenza yevana. Zvisinei, mahomoni, mararamiro, uye mararamiro ehupenyu zvinokonzera ((kusanganisira kuyerwa) vose vanogona kuita basa-zvichida pamwe chete. Kuziva njodzi yako pachako hakungokurevei kuti iwe unogona kuchinja iwe unogona kuita kuti uderedze njodzi iyo asi iwedzere kutarisira kwaunopa kune zviratidzo chero chipi zvacho zvaunogona kuwana kuitira kuti ugone kuvakudza nachiremba wako nekukurumidza.
Sezvaunenge uchiverenga, zvakakosha kuyeuka musiyano pakati pekugadzirisa (chinetso chinokonzerwa nechirwere) uye causation (iyo ngozi inowedzera inounza chirwere ichi). Kuva nechigadzirisa chinokonzerwa nekenza yevarivha hazvirevi kuti iwe uchakudziridza chirwere, kunyange kana dambudziko rako rakakwirira. Saizvozvowo, vanhu vakawanda vanoita kenza yevana vanenge vasina chekuzivikanwa kune ngozi.
Zvinowanzoitika Nengozi
Kanzira inotanga mushure mokutenderera kwezvinhu zvakasiyana-siyana mumagetsi (DNA) emukenza masero anovatungamirira kukura mune fashoni yekunze, sekunge kuti havafi. Nhamba dzinoverengeka pamusoro pokuti nei izvi zvichiitika zvave zvataurwa.
Estrogen Therapy
Izvi zvingawedzera kana kuderedza dambudziko rekenza yevana, zvichienderana nemhando. Hormone replacement therapy (HRT) inogona kuwedzera mungozi wekenza yevana, asi kana iwe ukatora mishonga yeestrogen-chete. Kusanganiswa nesrogen / progesterone HRT haina kuonekwa kuti inokonzera ngozi.
Birth Control
Kutora chirongwa chekudzivirira pamuviri (iyo Piritsi), zvakasiyana, kunoderedza ngozi yako kusvika kusvika ku50 muzana, nekureba kwenguva yekushandiswa kunobatanidza nekuderedza kukuru. Uku kuderedza njodzi kunopfuurira kwemakore anenge 30 mushure mokusiya Piritsi. Kuzvarwa kwekuberekwa kunopfurikidza (Depo-Provera) kunobatanidzwawo nehuwandu hwemungozi.
Kuva nevana
Kubereka mwana mushure mezera remakore makumi maviri nemasere kunodzora dambudziko rako rekuve nekenza yevana, sezvinoita mukuyamwisa. Kuva nemwana wekutanga pamusoro pemakore makumi matatu, zvisinei, kunobatanidza nehuwandu hwepamusoro.
Zuva Rokuguma Menguva Yekumambo
Kuenda kumwedzi kwenguva refu kunobatanidzawo nehuwandu hwehutano. Zvinogona kunge kuti nhamba yakawanda yehupenzi inobatsira inokurudzirwa kwekenza. Ovulation inokonzera kutuka, uye kuputika kunosangana nekenza, asi yakanyatsogadziriswa isingazivikanwi.
Surgery
Tubal ligation chirurgic rinogona kuderedza zvakanyanya dambudziko rekenza yevana mahara kusvika makumi manomwe muzana mune zvimwe zvidzidzo, kunyange zvazvo nzira dzeizvi dzisinganzwisisiki. Kuva ne hysterectomy kunoderedza ngozi iyo inenge yechitatu yechitatu.
Endometriosis
Endometriosis , chirwere umo uterine (endometrial) tissue inokura kunze kwechibereko, inobatanidzwa nehutano hukuru hwekenza yevana.
Infertility
Hazvine chokwadi panguva ino kana zvinodhaka (zvakadai seClomid) zvinokonzera njodzi yekenza yevana, kunyange nhoroondo yekusagadzikana inobatanidza nehuwandu hwehutano. Zvidzidzo zvakatarisa kubereka zvinodhaka uye kenza yemuvhaya hazvina kuona kuwedzera kwekuchengetedzwa kwezvirwere zvepithelial ovarian, asi pane zvishoma (uye kazhinji zvisinganyanyi kurwisana) zviremera zvemasero esimba.
Genetics
Kana iwe wakatarisa nyaya uye nhaurirano pamusoro pekuchinja kweBrCA , iwe unogona kunge unoziva kuti kenza yevarivha inogona kuva nhaka . Asi muzuva rino uye mazera apo kuenzanisa kwemajini kwakave itsva, zvakakosha kutaura pamusoro pemusiyano pakati pekuve nemhuri yekenza yekenza uye kuva neruzivo rwechimiro chekuchinja. Kuva nehutano hwepabonde kune kenza hazvirevi kuti iwe uchakudziridza chirwere ichi, kunyange iwe wakatakura genetic mutation.
Family History
Vakawanda vanotenda kuti kuedza kwakanaka kwekuchinja kweBBRCA kunokosha pakugadzirwa kwekenza yevana, iyo haisi iyo. Kune huwandu hwemajini anowedzera dambudziko rekenza yevana, asi rimwe chete ndiro BRCA gene.
Zvakakoshawo kuziva kuti pane mazana mashomanana emhando dzakasiyana dzeBrCA gene mutations, uye iyo ichangobva kuwanikwa i-it-yourself-gene inongororwa chete chengetedza zvishoma zveizvi.
Kana uine mhuri yekenza yemuviri (kune rumwe rutivi rwemhuri), ngozi yako inowedzera. Ngozi inonyanya kukosha kune avo vane chikwata chekutanga chechiremba vane chirwere ichi, saamai, hanzvadzi, kana mwanasikana. Kuva nehukama humwe nehutachiona hunosimudza dambudziko rinowedzera.
Heano mamwe mazano anokosha kuziva nezvehupenyu hwako hweBBRCA:
- Kana iwe uri BRCA usina kunaka: Une humwe huwandu hwehutachiwana hwekenza kana uine hama (kune rumwe rutivi rwemhuri) uyo ane kana ane kenza yemaawa uye BRCA gene mutation. Iwewo une ngozi yakawedzerwa kana iwe une nhoroondo yako pachayo yekenza yemazamu.
- Kana iwe uri BRCA rakanaka: Dambudziko rako rekenza yevana rinonyanya kukunda kupfuura munhu asina kuchinja. Inenge 40 muzana yevakadzi vane BRCA1 kuchinja uye 20 muzana yevaya vane BRCA2 kuchinja kwezvinhu zvinotarisirwa kuve nekenza yevavari muhupenyu hwavo hwose. Kenza yeOvarian mune vanhu ava inowanzoitika kune imwe nguva yakatarisa kupfuura iyo inoita kune avo vasina mutsika, uye aya kanzira inowanzotyisa zvakare.
Kana iwe unofungidzira kuti BRCA yega yega yega inofamba mumhuri yako, taura nachiremba wako nezvekufanirwa kuedza kuongorora BRCA . Kana iwe uine hanya, kuona chimiro chemajini kunokosha. A mazano emagetsi anogona kutarisa mapepa mumhuri, kusanganisira kuvapo kwevamwe kanzira inogona kubatanidzwa nehuwandu hwekenza yemukenza (yakadai sekenza yemazamu, kenza yemaroni, kenza yepancreatic, kenza yeprostate, nezvimwe). Ichokwadi, vamwe vanhu vanogona kuonekwa kuti vane kambani yakanyanya yekenza yemaawa anobva mumhuri yavo nhoroondo yekenza yakadai kupfuura avo vane ruzivo rwekuchinja.
Mhuri yeCancer Syndromes
Kusvika 10 kubva muzana yemukondombera yevana vanowirirana kune imwe yekenza mhuri ye syndromes iyo inonzi gene gene mutation iripo. Zvakawanda zve syndromes idzi zvine chokuita nekuchinja kwemuviri mune izvo zvinozivikanwa sechirwere chekudzivirira zviyero , iyo purogiramu yemapurotini anogadzirisa DNA yakaora mumasero. Izvi zvinosanganisira:
- Lynch Syndrome ( kanzvadzi isina ma polyposis kanoroni yekoloni kana HNPCC): Vakadzi vane HNPCC vane mukana we10 muzana wekudzivirira kenza yevana (pamwe chete nehutano hwakanyanya hwekudzivirira kenza yekoloni uye ngozi ine mwero yekenza yebereki). Kune mazita akasiyana-siyana akasiyana-siyana anogona kuchinjwa mune chirwere ichi.
- Peutz-Jeghers Syndrome: Ichi chirwere chinokonzerwa nekuchinja kwomuviri weGNA STK11 uye chinosanganiswa nehuwandu hwekenza yevana. Iyo inobatanidzawo nekuumbwa kwemakondohoni emakoloni uye kuwedzerwa kungozi kwezvimwe zvirwere zvekudya zvekenza.
- Chirwere cheCowden : Inonziwo tumor hamartoma syndrome, ichi chiitiko chakabatana nekuchinja kwemajini PTEN. Inowedzera njodzi yezvipembenene zvinotapira zvinonzi hamartomas , pamwe nekenza yevavari, kenza yemazamu, nekenza yekameti.
Kureba
Vakadzi vanoreba (kupfuura mamita mashanu masendimita 8) vanowanzova nekenza yepamusoro yevarusi kupfuura vakadzi vfupi. Hazvizivikanwe kana izvi zvakabatana nehupamhi pachayo kana kuti iyo yakakwirira yakasungirirwa ku genetics iyo inoshanda sechiitiko chinokonzerwa nekenza yevana.
Lifestyle Risk Factors
Maitiro eupenyu anokwanisa kuita basa mukugadzirwa kwekenza yevana, uye mazhinji aya (kusiyana nemhuri yako yekare) inogona kuchinjwa kana kudzorwa.
Kuwedzera muviri
Kuwedzera muviri kunobatanidza nehuwandu hwehuwandu hwema-serous uye hune hutachiona hwemucinous tumor (zvirwere zvekenza epithelial ovarian) asi hazviratidzi kuwedzera kungozi yekodhi yepamusoro-grade inouraya serous cancers. Kuwedzera muviri kunoratidzika kunge kunobatanidza zvakare ne premenopausal kupfuura zvirwere zvemasmenopausal.
Kune nzira dzakasiyana-siyana dzave dzakarongedzwa. Imwe ndiyo kuwedzerwa kweesrogen inobatanidza nekuwedzerwa (mafuta ane mishonga inobereka androgens inoshandurwa kuva estrogens). Kuwedzera muviri kunowanzokonzera muviri kuti uwedzerwe insulin uye insulini-yakakura kukura-1 (IGF-1) iyo inogona kukurudzira kukura nekukura kwemamwe matumbo. Uyezve, kuneta kunowedzera kuputika, izvo zvakabatanidzwa nehuwandu huwandu hwekenza.
Zvinosuruvarisa, vakadzi vanorema kana kuwandisa kwepamusoro variwo mungozi yakanyanya yekufa kubva kune kenza yevana varipo panguva ino. Kurasikirwa mapaundi mashanu kusvika ku10 kunogona kuderedza ngozi yako.
Talc Shandisa
Kushandiswa kwemashirasi emadzimai uye mapurusi ane talc akabatanidzwa nekenza yevana. Nenzira yakanaka, zvakajeka kubvisa chikonzero ichi chekutadza.
Kudya
Zvidzidzo zvishomanana zvakawana kuti kudya kwakaderera kwemafuta kunobatanidzwa nehutano huri pasi hwekenza yevana, asi pane huchapupu hushoma huwandu hwekuti kudya kunoita basa rinokosha.
Zvine kufarira, curcumin, kemukari mune yakafanana curry ingredient turmeric, yave ichibatanidzwa nehutano huri pasi hwekenza yevarivha mumapurogiramu evanhu uye mabhuku ekuongorora. Kunyangwe tsvakurudzo dzakawanda dzinodiwa, kana iwe unofarira zvinonhuwira, hazvigoni kukuvadza kuzviisa mukati mokudya kwako kakawanda.
Kusvuta
Kusvuta kunobatanidzwa kune imwe mhando yekenza yemaawa: mucinous epithelial tumors. Zvisinei, kupa huwandu hwekenza hunokonzerwa nokusvuta , kurega pfungwa yakanaka.
Kuongorora
Hapana hutungamiri hwekuongorora hutachiona ichi, kunyanya nokuti kuongorora kunosuruvarisa kusina kuwanika kuderedza kufa kwehutano hwehupombwe. Uyezve, miedzo yakadaro inogona kutungamirira kumigumisiro isina kunaka, yakadai sokuvhiyiwa pasina.
Vamwe vanachiremba vanogona kurumbidza kaviri gore rimwe nerimwe transvaginal ultrasound uye CA-125 kuongororwa ropa (kutanga pazera remakore makumi matatu kana makore ose ane makore gumi vaduku kudarika apo hama yakarongerwa) kune avo vane mhuri yemhuri yevana kana mahara ane hutano, kana avo vane ruzivo rwekuchinja . Zvisinei, iyi haisi tsika yakabatana yezvikonzero zvakafanana. Kubviswa kwema tubes uye mazai (salpingo-oophorectomy) kunoderedza dambudziko rekenza yevarivha ne 75 muzana kusvika 90 muzana.
Ichi ndicho chikonzero chikuru chekuti uve nechokwadi chekuunza chero zviratidzo zvekenza yevana , kunyange izvo zvisinganzwisisiki uye zvisinganzwisisiki, kutarisira chiremba wako.
> Sources:
> Henderson, J., Webber, E., naG. Sawaya. Kuchengetedza kweAvarian Cancer: Mharidzo yeEvidence Report uye Ongororo Yakarongeka yeUnited States Preventive Services Task Force. JAMA . 2018. 319 (6): 595-606.
> National Cancer Institute. BRCA Kuchinja-chinja: Cancer Risk uye Genetic Testing. Updated 01/30/18. https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet
> National Cancer Institute. Ovarian Epithelial, Fallopian Tube, uye Primary Peritoneal Cancer Treatment (PDQ) -Health Professional Version. Updated 01/19/18. https://www.cancer.gov/types/ovarian/hp/ovarian-epithelial-treatment-pdq
> Seo, J., Kim, B., Dhanasekaran, D., Tsang, B., uye Y. Rwiyo. Curcumin Induces Apoptosis neInhibiting Sarco / Endoplasmic Reticulum Ca2 + ATPase Chiitiko muAvarian Cancer Cells. Cancer Tsamba . 2016. 371 (1): 30-7.
> Tworoger, S., uye T. Huang. Kuneta uye Ovarian Cancer. Kuneta uye Ovarian Cancer . 2016. 208: 155-176.