Lynch syndrome kana kuti nhengo dzisina ruzivo rwemapurisa (HNPCC) inowedzera mukana wekugadzira makoni nemamwe makondombera. Kuchengetwa kwechiremba uye chirongwa chakazara chekuongorora chirwere chinogona kutarisira ngozi idzi.
Lynch Syndrome (HNPCC), Genetics, uye Familial Cancers Colon
Inenge 75% yekenza yemakoroni ndeyezviitiko zvepora . Izvi zvinoreva kuti havana zivo inokonzerwa nehutachiona kana nhoroondo yemhuri yemunhu kune uyo anoonekwa ane chirwere.
Pakati pezvimwe zvinokonzera kenza yekoloni ndeye Lynch syndrome kana kuti nherera isina nonpolyposis cancerrectal cancer (HNPCC).
Lynch syndrome inokonzera 2-7% yekodha yekenza mamiriro ezvinhu akawanikwa muUnited States. Tichifunga kuti vanenge 160 000 vanhu vanoonekwa kuti vane kenza yekoloni gore roga roga, izvi zvinoreva pakati pe 3 200 ne11 200 zveavo mhondi yekoloni inokonzerwa neLynch syndrome.
Nekuwedzera kwehutano hwekenza yekoloni, vanhu vane Lynch syndrome vanogona kuva nehuwandu hwekuwedzera dzimwe kenza, kusanganisira kanzira dze rectum, dumbu, duku mudumbu, chiropa gallbladder ducts, chikamu chepamusoro chemagetsi, uropi, ganda, prostate, chibereko ( endometrium), uye maovha. Mhuri umo Lynch syndrome iripo inowanzove yakasimba yemhuri yekenza. Nekuedzwa kwema genetic kuve yakawanda kwazvo, vazhinji vemhuri idzi vanoziva kuti vane maitiro ekuchinja anokonzera Lynch syndrome.
Ichi ndicho chikonzero nei zvakakosha kunyora nhoroondo yemhuri yako.
Vanhu kazhinji havafungi nezvevamwe kanzira sefa, asi kana vakawedzerwa pamwe iyo link inowanikwa.
Inonzi Lynch Syndrome Inherited?
Lynch syndrome inopfuudzwa kubva kuvabereki kuenda kune vana nekuda kwekuchinja kwemajini mana: MLH1, MSH2, MSH6, uye PMS2. Genesisi ndiyo bhuku rekudzidzisa nekuvaka muviri wemunhu.
Inenge imwe yesevha mumitumbi yedu ine mapepa maviri ega rimwe nerimwe. Imwe kopi inobva kuna amai vako uye kopi imwe inobva kuna baba vako. Nenzira iyi, kana amai kana baba vane kuchinja mune imwe kana kuti mazana emakemikari anokonzera Lynch syndrome, vanogona kudarika kuchinja uku kuvana vavo, kana vachipfuura nemagetsi avo.
Kune dzimwe zvirwere, kana imwe yemashiripiti maviri ejeni yakanganisa kana iripo, imwe, yakanaka, kopi, inoshanda zvakanaka uye hakuzovi nechirwere kana kuwedzerwa njodzi yezvirwere. Izvi zvinonzi autosomal recessive pattern .
Kune dzimwe zvirwere, kusanganisira Lynch syndrome, kana kunyange imwe kopi yemagetsi yakaremara kana kushayikwa, izvi zvakakwana kuwedzera ngozi kana kuti kukonzera chirwere. Izvi zvinonzi "autosomal" yakawanda. Zvisinei, zvakakosha kuyeuka kuti ingozi yepamusoro yekenza inowanikwa muvanhu vane Lynch syndrome. Kanzira pachayo haina kupiwa nhaka uye kwete vose vane Lynch syndrome vachava nekenza.
Mukuwedzera kune Lynch syndrome, pane mamwe mazita ehutano anokonzera kenza yekoloni iyo inokosha kunzwisisa uye zvichida kuti kunyanya kuwirirana kuchawanikwa munguva yemberi iri pedyo.
Zvakanakisisa Zvokudzivirira
Tinofara kuti tinorarama munguva iyo iwe haufaniri kumirira uye kuona.
Kune nzira dzekuongorora mararamiro, uye kunyange kana mumwe munhu ane ruzivo rwehutachiona, tiri kudzidza zvakawanda nezvedzimwe nzira dzekudzikisa dambudziko iri. Kuva nemhuri yekenza yekenza haisi nguva yakaipa chinhu kana ichipa simba vanhu kutarisira hutano hwavo. Muenzaniso weiyu uri nekenza yemazamu, iyo inenge inenge 10% ine genetic link. Vakadzi vane nhoroondo yemhuri vanowanzova nechokwadi chekuti vanoongororwa uye havamiriri kuti bundu riongorore. Kana ivo vachiva nekenza, zvinogona kuwanikwa kare pane kune mumwe munhu mu 90% vasina kunyanya kunetseka nekuda kwekushayikwa kwemhuri.
Kufunga pamusoro pezvakagadzirirwa nenzira iyi kwakabatsira vamwe vanhu zviri nani kukunda dambudziko ravo.
Genetic Counseling
Kana iwe ukaona kuti une Lynch syndrome, taura nachiremba wako pamusoro pokutumira kunotarisa kuona mazita ekupa mazita. Chiremba wako anogona kukubatsira kuti uwane munhu anokwanisa ma genetic munharaunda yako kana unogona kutsvaga National Society of Genetic Counselors website kuti uwane genetic counseling resources. Kuona ruzivo rwemajini kunokosha nekuti hausi kuchinja kwemajeni akabatwa kunoguma nehuwandu hwehutano hwekenza. Dzimwe shanduko dzinogona kuwedzera njodzi chete zvishoma, asi dzimwe shanduko dzinogona kuwedzera zvikuru kenza ngozi. Zvakakosha kuziva iwe pachako panjodzi kuitira iwe unogona kukura chirongwa chekugadzirisa.
Cancer Screening
Danho rechipiri rinokosha raunogona kutora nderokutaura nachiremba wako nezverongwa hwekuongorora kenza. Kune vazhinji vanorwara nekenza, kusanganisira chirwere chekoloni, kuongororwa nyore nyore kuongororwa kunoonekwa. Uye kunyange nokuda kwekenza mhando dzisingasarudze kuongorora, zviyero zvakadai seT CT scans uye MRI miedzo zvinogona kushandiswa kuwana kenza pamakatanga ayo ekutanga, kana ichirapa.
Sezvo zita iro risina hanya nepolyposis rinokonzerwa nekenza rinoratidza, izvi zvinowedzera njodzi yekenza yekoloni pasina kuwedzera kungozi yemapuropiti. Polyps inokura mumakoloni iyo kana isingateereri, inogona kukura kuva kenza yekoloni. Izvi hazvirevi kuti vanhu vane Lynch syndrome havakwanisi kuwana mapepa. Zvinongoratidza kuti ivo vanowanzova nekenza yekoloni vasati vatanga kuwedzera mapuropa. Nokuda kwechikonzero ichi, kuongororwa kwekodonoscopy kwechirwere ichi kunogona kuva kwakaoma zvikuru, asi tsvakurudzo inotsigira kuti colonoscopy inonyatsoona kenza yekoloni inobatanidza neLynch syndrome. Colonoscopy chikamu chinokosha chekutarisira Lynch syndrome.
Iwe unogona kunge uchida kuongororwa kubva pazera ruduku uye kakawanda kupfuura vanhu vasina Lynch syndrome. Kunyange zvazvo izvi zvingaita sekunetseka kwakakomba, ndiyo imwe yenzira dzakanakisisa dzokugadzirisa dambudziko rako rakawedzera rekenza, kusanganisira kenza yemaroni.
Kune Mamwe Mashoko Akanaka
Kunyange zvazvo pasina munhu anoda kuve neLynch syndrome, kune imwe chete yenyaya dzakanaka pamusoro pechiratidzo ichi. Muna 2008, vaongorori veItaly vakabudisa tsvakurudzo inoratidza kuti varwere vanorwara neLynch syndrome vanoita zvakanyanya kupfuura vamwe varwere vanorwara nekenza. Vanhu vane Lynch syndrome vane zvirwere zvakanyanya zviri nani, uye 94% yevarwere ava vachiri kurarama makore mashanu mushure mekuongororwa, zvichienzaniswa nemakore mashanu ekupukunyuka kwezana re 75% kune avo vane kenza yepoloni yepoloni . Pane zvikonzero zvakawanda zvinokonzerwa neizvi, zvichibva pakuonekwa kwokutanga kune vanhu vane Lynch syndrome nokuti vari nani pakuwana kenza yemukironi kuongorora kune kusiyana kwehupenyu hwemhando dzakasiyana dzekenza yekoloni. Chero nzira, iyi inhau dzinosimudzira.
Sources
Colorectal Cancer Coalition. Lynch Syndrome. .http: //fightcolorectalcancer.org/prevent-it/risk-factors/lynch-syndrome
Gene Reviews. Hereditary Non-Polyposis Colon Cancer. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=hnpcc
Genetic uye Rare Diseases Information Center. Yakasvika: 02/21/16. http://rarediseases.info.nih.gov/GARD/
Lindor NM. Kugadzira nyaya yekucherechedza colonoscopy muLynch syndrome. Colorectal Disease, 2009 11: 131-32.
The National Institutes of Health. Lynch Syndrome. http://ghr.nlm.nih.gov/condition=lynchsyndrome