Isentress (ratelgravir) inonzi integrase inhibitor -chirwere chetachiona chinoshandiswa mukurapwa kweHIV . Isentress ndiyo yekutanga integrase inhibitor inobvumidzwa neU.S. Food and Drug Administration (FDA).
Muna Gumiguru 2007, yaive nemvumo yekushandiswa kune vanhu vakuru avo vairwisa mamwe madhiragi anorapwa . Asi munaJuly 2009, uye gare gare munaDecember 2011, FDA yakawedzera kuratidza kwayo, ichibvumira kushandiswa kune vose vakuru vane HIV, pamwe nevana vane makore maviri kusvika ku18.
Isentress iri pakati pezvinodhaka izvo zvino zvinokurudzirwa semasarudzo ekutanga-mutsara ekurapa HIV muSouth America
Formulations
Isentress inowanikwa mune maitiro mana akasiyana:
- Kune vanhu vakuru uye vana vakwegura, Isentress inowanikwa semapiritsi 400mg akafukidzwa nefirimu, ovha muhumi uye pink-orange-ruvara. Nhamba ye "207" yakaiswa kune rumwe rutivi.
- Kana vana vasingakwanisi kutora mahwendefa, Isentress inowanikwa sewe 100mg chewable (oval, beige, embossed kune rumwe rutivi ne "477," yakagadzirirwa kuparadzaniswa) kana 25mg chewable (yakasvibirira, yakakomberedza, yakaiswa pamativi maviri ne "473 "). Zvose izvi zvinorineni-bhanana inofungidzirwa.
- Nokuti vana vaduku havagoni kutora chewables, Isentress inowanikwa mune imwe chete-pack, 100mg muromo kusimwa. Kusimwa kwemukati kunosanganiswa ne 5mL emvura uye inoshandiswa nesirin'i yomuromo. Kana imwe yakavhenganiswa, kugadzirisa muromo kunofanira kushandiswa mukati maminitsi makumi matatu, uye chero zvasara zvichangosiyiwa. Kuvhiringidzwa kwebhanana kunofadza.
Usambogadzirisa Isentress chewables kana muromo kumiswa kweIsentress film-coated mapiritsi sezvo maumbirwo acho asina bioquivalent. Shandisa chete sezvakarayirwa (ona Zvikamu zviri pasi).
Dosages
Isentress 400mg, mahwendefa akafukidzwa nefirimu inofanira kunyorerwa kuvanhu vakuru uye kuvana vakwegura vanogona kumedza mahwendefa, sezvinotevera:
- Vakuru: imwe piritsi ye 400mg, inotorwa kaviri pazuva
- Kune vana kana vari kuyaruka 55 pounds (25kg) kana kupfuura: imwe 400mg tablet, inotorwa kaviri pazuva
Isentress chewable mahwendefa inofanira kurongerwa kune vana inorema makirogiramu makumi mana (20kg) kana kupfuura avo vasingakwanisi kumedza mahwendefa, sezvinotevera:
- 44 makirogiramu (20kg) kusvika pasi pemamiriyoni makumi mana (28kg): 150mg kaviri zuva rimwe nerimwe
- 62 makirogiramu (28kg) kusvika pasi pe 88 pg (40kg): 200mg kaviri zuva rimwe nerimwe
- Anopfuura makirogiramu makumi mana (40kg): 300mg kaviri zuva nezuva
Isentress oral suspension kana chewable mahwendefa inofanira kurongerwa kune vana vanorema makirogiramu anenge 3kg kusvika pasi pemaundi 55 (25kg), sezvinotevera:
- 6.5 makirogiramu (3kg) kusvika pasi pe8.8gg: 1mL (20mg) yakagadzirirwa kusimwa mumuromo kutorwa kaviri zuva nezuva
- 8.8 makirogiramu (4kg) kusvika pasi 13 pounds (6kg): 1.5mL (30mg) yakagadzirirwa kunyungurwa kwemuromo kutorwa kaviri pazuva
- 13 makirogiramu (6kg) kusvika pasi pemapirogiramu (8kg): 2mL (40mg) yakagadzirirwa kusimwa mumuromo kutorwa kaviri zuva nezuva
- 17 makirogiramu (8kg) kusvika pasi pemapirogiramu (11kg): 3mL (60mg) akagadzirirwa kumiswa kwemuromo kutorwa kaviri pazuva
- 24 makirogiramu (11kg) kusvika pasi pemaundi 30 (14kg): 4mL (80kg) yakagadzirirwa kusimwa mumuromo kutorwa kaviri zuva rimwe nerimwe OR 75mg mahwendefa anokwanisa kutorwa kaviri pazuva
- 30 makirogiramu (14kg) kusvika pasi makirogiramu makumi maviri (20kg): 5mL (100kg) yakagadzirirwa kusimwa mumuromo kutorwa kaviri zuva rimwe nerimwe OR 100mg mahwendefa anocheka anotorwa kaviri pazuva
Drug Administration
Isentress inogona kutorwa kana pasina kudya. Isentress haikwanisi kutorwa payo uye inofanira kurongerwa sechikamu chekubatanidza antiretroviral therapy (kadhi) .
Nharaunda Dzakabatana
Zvinonyanya kuzivikanwa nemigumisiro yakaipa (inowanikwa mu2% kana pasi pezviitiko) ndeiyi:
- Kunyunyuta
- Headache
- Chizutu
- Nausea
- Kuneta
Contraindications
Hapana
Zvinodhaka-Zvinodhaka Zvinodhaka
Ndapota vaudza chiremba wako kana iwe uri kutora chero ipi zvayo inotevera mishonga sezvo isingabvumirwi kubatanidzwa pamwe neIsentress uye inogona kupindira nehuwandu hwezvinodhaka:
- Rifampin-based antibiotics: Rifadan, Rifater, Rifamate, Rimactane
- Aluminium- kana kuti magnesium-based antiacid (eg, Tums, Milk of Magnesia, etc.)
Kufunga
Varwere vanoona zvirwere zvinotapira mushure mokutanga Isentress vanofanira kuonana nachiremba wavo pakarepo. Mishonga inofanira kumira uye kurapwa kwakatsvaga kana kukanganisa kunoperekedzwa nefivha, musuru kana hutano hunojoka, blisters kana maronda, kuchena kana kuvhara kwemaziso, kuvhara kwechiso kana muromo, kana zvinetso zvokufema. Varwere avo vakambotarisana ne hypersensitive reaction yeIsentress havafanirwi kuchinjwa zvakare nemishonga mushure mekugadzirisa zviratidzo.
Zvidzidzo zvezvipfuwo hazviratidzi mazai embryotic kana kuti fetal birth birth defects panguva yekuzvitakura mumakonzo kana marabvu akaratidzwa kuIsentress. Zvisinei, zvinokonzerwa neIsentress pamucheche nechecheche dzisina kunyanya kushandiswa, uye, semugumisiro, kunyamwa hazvikurudzirwi kuti vanaamai vatore Isentress.
Sources:
Dhipatimendi reHutano neHuman Services (DHHS). "Mirayiridzo yeKushandiswa kweAntiretroviral Agents muHIV-1-Vakabatwa Vakuru Nevana Vari Kuyaruka." Rockville, Maryland.
FDA. "FDA Inowedzera Kushandiswa kweHIV Drug Isentress kune Vana uye Vana Vachiri Kuyaruka." Silver Spring, Maryland; December 21, 2011.
Reuters. "UPDATE 2-FDA OKs Kuwedzerwa Kushandiswa kweMerck's Isentress HIV Mishonga." July 9, 2009.
US Food and Drug Administration (FDA). "Kurapa Zvinodhaka Mishonga - Zita reMishonga: Isentress (ratelgravir) 400mg Matetet." Silver Spring, Maryland; Gunyana 12, 2007.