Chimwe chimiro chakakosha uye chiitiko chinokurudzira chinofungidzirwa kuti chinokonzera mamwe marudzi eArthritis. Semuenzaniso, vatsvakurudzi vakaona kuti vanenge 40 muzana yevanhu vane psoriasis kana psoriatic arthritis vane nhoroondo yemhuri yezvirwere zvinosanganisira yekutanga-degree hama. Zvidzidzo zvemhuri zvakaratidza kuti psoriatic arthritis inowanzove yakawanda 55 yekuwedzera mumhuri yekutanga yehukama hwevanhu vane chirwere ichienzaniswa nekutonga kusina kukodzera.
Mune zvidzidzo zvemajeni, izwi rechibvumirano rinoreva kuenzana kwekufananidzwa mune rimwe remawere maererano nekuvapo kana kusavapo kwechirwere kana chiito. Iko concordance chiyero che psoriatic arthritis (30 muzana) yakakwirira kwazvo kupfuura ye psoriasis (7 muzana). Chidzidzo chechipiri cheporioriasis chakaratidza huwandu hwakawanda hwekubvumirana pakati pemapatya akafanana nemapatya ehama.
Kuziva maitiro akabatanidzwa nekunetseka kune chimwe chirwere hachisi chinhu chiduku. Inogona kusanganisira:
- Mhuri yekudzidzira zvidzidzo: Kutsvaga kubatanidza kwechirwere mumhuri.
- Kusarura kuongorora: Kuziva kana geni guru rakabatanidzwa pakupararira kweimwe nhengo ye phenotypic (kureva, chiitiko chinocherechedza).
- Kubatanidzwa kwehutano: Kuziva sangano rekuzvidzivirira pakati pemagenene zvichienderana nenzvimbo yavo pane chromosome.
- Association analysis: Kuwana hukama kubva kune data, munyaya iyi, kutsvaga mazita emagetsi kana nzvimbo dzema genome dzinobatsira kune chimwe chirwere.
- Zvidzidzo zvinoshandiswa pakujekesa maitiro ejeni: Kudzidza kuchinja kwepanyika kana kuongororwa kwekushanda kunoitika kunobata majeni, makromosomes, nezvimwewo.
Inonzwisisika yakaoma uye inovhiringidza? Icho, sezvinogona kuva nomenclature . Asi, ngatitarisei pane zvakawanikwa.
HLA (Human Leukocyte Antigen)
Kuwanikwa kweMHC (yakakura histocompatibility complex) pamusoro pekromosome 6 yakanga yakakosha kuongorora maitiro ezvinyorwa mune psoriatic arthritis.
Zviverengeka zvakasiyana-siyana zvepabonde zvakaonekwa. Kune hukama hunonyatsozivikanwa pakati peHLA (human leukocyte antigen) nzvimbo yeMHC inozivikanwa seHLA-C, uye kunyanya HLA-Cw6, uye inogadziriswa ku psoriasis. Kushamwaridzana neHLA-Cw6 kunopera simba mu psoriatic arthritis, umo HLA-B27 inowedzera kushamwaridzana (kunyanya kune vanhu vane maginhiro emusana we psoriatic arthritis), sezvinoitwa HLA-B38 neHLA-B39. HLA-Cw6 inobatanidza nekutanga kwe psoriasis (pasi pemakore makumi mana) uyewo zvirwere zvakanyanya. Mamwe maitiro anonzi HLA antigens, inozivikanwa kuti HLA-B13, HLA-B17, HLA-B57, uye HLA-Cw * 0602 inowanzoitika kune vanhu vane psoriatic arthritis vachienzaniswa nevanhu vazhinji.
Izvozvo zvinotevera (imwe yeviri kana kupfuura mamwe maitiro ejeni inokura nekuchinja, yakawanikwa panzvimbo imwechete pane chromosome) yakawanikwa ichibatanidzwa zvikuru ne psoriatic arthritis yakaenzaniswa ne psoriasis: B * 8, B * 27, B * 38, uye C * 06. Ikokowo pane HLA haplotypes (boka rejeni rakagara nhaka pamwe chete kubva kumubereki mumwe chete) rinobatanidzwa ne psoriatic arthritis: B * 18, C * 07, B * 27, B38, uye B * 8.
Kunyange zvazvo HLA-B27 inonzi iine yepamusoro-shanduko inofanirwa kukosha ye psoriatic arthritis vs. psoriasis, haisi chokwadi.
Kuwanda kweHLA-B27 kwakanyanya mune ankylosing spondylitis uye reactive arthritis yakaenzaniswa ne psoriatic arthritis. Zvakakoshawo kutaura kuti vanhu vazhinji vane psoriasis uye imwe yepondyloarthropathies haina kunaka kweHLA-B27. Uyezve, vanhu vazhinji vane psoriatic arthritis vane hutano hweHLA-B27 havaratidzi mushure mekubatana.
Dzimwe dzidzo dzakaratidza kusangana pakati pe psoriatic arthritis neHLA-DR4 , an antigen iyo inozivikanwa kuti inobatanidza ne rheumatoid arthritis . Izvo zvose zvinopesana pakati pemamiriro maviri aya, zvisinei, neHLA-DRB1 * 0401 zvishoma kudarika kune vanhu vane psoriatic arthritis vane hutano hweHLA-DRB1 * 04 kupfuura vanhu vane rheumatoid arthritis.
Izvo zvakashata ndezvechokwadi kune HLA-DRB1 * 0402, iyo inonyanya kuitika mumapuroriyamu arthritis kupfuura rheumatoid arthritis. Mamwe mazai mukati memhara yeMHC ave akadzidzawo zvakare.
GWAS (Genome-Wide Association Scans)
Sangano revanhu vese rinotarisa (GWAS) rinotsvaga maitiro akasiyana-siyana evanhu kubva kune vanhu vakasiyana-siyana mukuedza kuziva kana pane zvakasiyana-siyana zvinosanganiswa nemuitiro. Maererano neHinzvi Practice & Research: Clinical Rheumatology (2014), majee 36 akawana mazita emagemu-akaenzana uye anoverenga nezve 22% ye psoriasis heritability. Zvisikwa zvakazivikanwa neGWAS zvinonzi zvakakurumbira mumapuroriasis zvinosanganisira HLA-Cw6, IL12B, IL23R, IL23A, TNIP1, TNFAIP3, LCE3B-LCE3C, TRAF3IP2, NFkBIA, FBXL19, TYK2, IFIH1, REL, uye ERAP1. Zvisikwa zvakagadzirirwa neGWAS izvo zvakakurumbira mumapiroriki epiritiki zvinosanganisira HLA-B / C, HLA-B, IL-12B, IL-23R, TNIP1, TRAF3IP2, FBXL19, uye REL.
Pasi Pasi
Kana iwe uine nhengo yemhuri ine psoriatic arthritis, kudzidza kuti zvidzidzo zvakaratidza nguva makumi mashanu zvakapfuurirwa yekuvandudza chimiro chinogona, zvinonzwisisika, chinotyisa. Zvidzivirire nezivo yakarurama-zvichida une mafungiro asina kunaka pamusoro pemamiriro ezvinhu echokwadi anogona kubatsira kururamisa, kuderedza kushushikana kwako. Uye, zvechokwadi, ramba uchitaurirana pachena kune unyanzvi hwehutano.
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