Vamwe vatsvakurudzi vanotenda kuti amyloid inopisa pfungwa inonyatsotsanangura chinokonzera chirwere cheAlzheimer .
Kunyange zvazvo mibvunzo yakawanda isati isingapindurwi, i-amyloid inopisa pfungwa inoratidza kuti kunyanya kuunganidza peptide inonzi amyloid-beta ndiyo chiitiko chinokosha muAlzheimer's disease: Uku kuunganidza kunoitika zviitiko zvinokonzera rufu rwemasero europi, uye pakupedzisira, Chirwere cheAlzheimer.
Iyo Amyloid-Beta Inogona Kukonzera Alzheimer's
Amyloid-beta inoumbwa kubva puroteni yakakura inonzi amyloid precursor protein (APP). Vatsvakurudzi havanyatsoziva basa reCAP, asi rinogona kukanganisa basa remasero europi. Mazimbe emurairo (anonzi secretase) akacheka mapuroteni aya pane dzimwe nzvimbo, uye chimwe chezvinhu zve "cleavage" iyi ndiamyloid-beta peptide. Aya ma-amyloid-beta peptides anopinda pamwe mune izvo zvinonzi oligomers, uye maererano neamyloid kuputika pfungwa, ndiyo maligomeri aya ane uturu kune masero europi, zvichikonzera matambudziko epakutanga okufungisisa muAlzheimer's disease. Gare gare, ma oligomeri aya anogadzira mapepa ane chimiro chechirwere cheAlzheimer, asi ndiwo oligomeri - kusiyana nemarata-ayo ndiwo mahedheni chaiwo.
Kunyange zvazvo mitsara yakawanda yehupupuriro iyo inotsigira amyloid inopisa pfungwa, kunewo matambudziko akawanda kune iyo.
Chimwe chikonzero, amyloid-beta iyo inowanikwa mumarata inowanikwa mukukwegura kwakakwana pamwe nehosha yeAlzheimer's. Kune imwe, zvinyorwa zveimwe puroteni inonzi tau fomu tangles iyo inobatanidza zviri nani nemagariro ekufungisisa muAlzheimer's disease kupfuura do plaques. Pakupedzisira, pane dzimwe nzira dzedzidziso dzakasiyana-siyana, dzakadai se mitochondrial cascade hypothesis, izvo zvakagadziriswa sezvinotsanangurwa zvinokonzera chirwere cheAlzheimer.
Kunobva:
Christensen DD. Chirwere cheAlzheimer: kufambira mberi mukuvandudzika kwema anti-amyloid-kuchinja kurapwa. CNS Spectr. 2007; 12: 113-123.
-Article yakarongwa naEstere Heerema, MSW