SPS Inokonzera Musungo Stiffness uye Kupera
Stiff person syndrome (inonziwo Moersch-Woltmann syndrome) kana SPS isingaoneki nervous system disorder umo kusuruvara kwemasumbu kunouya uye kunoenda. Kutsvakurudza kunoratidza kuti munhu akaomeswa chirwere chinokonzerwa nemararamiro evanhu, uye vanhu vane chirwere chinowanzova nehutachiona hwemagadzirirwo akadai sorudzi rwechirwere cheshuga kana thyroiditis .
Munhu ane hutachiona ane hutano hunovhiringidza varume nemadzimai uye anotanga pazera chero ripi zvaro, kunyange hutano hunoonekwa panguva yehuduku hushoma.
Hazvizivikanwi kunyangwe vanhu vazhinji vanotambura nei.
Zviratidzo zveStiff Person Syndrome
Zviratidzo zvehutano hwemunhu hunogona kusanganisira:
- Utsi hwakasimba mumatanda nemakumbo anouya uye anoenda - izvi zvinokonzera kusagadzikana kana kurwadziwa, kuwedzererwa kwakanyanyisa kwakanaka, kufamba kwakasimba
- Misi miviri yakakura mumakumbo nemakumbo apo munhu anotanga, akabata, ane shungu, kana kuti ane hanya
- Rwendo rwakadzika kumashure (lordosis) uye maronda akaremara mumuviri, kupfuura nguva
- Kuwira panguva dzomumatumbo zvinokanganisa (zvinogona kukonzera matambudziko akawedzerwa akafanana)
Kuongororwa kweStiff Person Syndrome
Zviratidzo izvi zvinoratidza kufungidzirwa. Zvisinei, nokuti iri chirwere chisingawanzoitiki, inogona kuongororwa zvisina kunaka sehosha yaPasinson , multiple sclerosis , fibromyalgia , kana chirwere chepfungwa.
Kuongorora kune dzimwe nguva kunogona kusimbiswa nekuvapo kwema anti-GAD antibodies, kana mamwe marudzi ezvirwere kana chirwere chinosangana nemamwe makondombera.
Zvisinei, 35 muzana yevarwere vane hutachiona hwehutano hwevanhu vane vasina antibodies uye hapana maronda anokonzerwa.
Dzimwe mimwe miedzo inogona kuitwa, yakadai se hemoglobin A1C kuti iongorore chirwere cheshuga kana utachiona-hunokonzera hormone (TSH) kutarisa thyroiditis. Tsvina yekuongorora (electromyography kana EMG) inogonawo kuitwa.
Kurapa kweShuff Man Syndrome
Kunyange zvazvo pasina mushonga wevanhu vakaoma, chirwere chinowanika. Zvinodhaka zvakadai se azatioprine (Azasan), diazepam (Valium), gabapentin (Neurontin), tiagabine (Gabitril), kana baclofen (Lioresal) inogona kushandiswa. Zviratidzo kune avo vane kenza zvinogona kuvandudzwa mushure mokunge bundu racho rabviswa uye kurapwa kwe steroid kunopiwa. Plasma exchange (plasmapheresis) inobatsira kuderedza zviratidzo kune vamwe vanhu, asi kurapwa uku kunowanzochengeterwa avo vane upenyu hunopisa kufema kupera. Kune vamwe, kubata immunoglobulin (IVIg) kunobatsira. Kurapa kwepanyama kunogona kubatsira kubvisa zviratidzo zvine chokuita nekuwedzera kwemaviri emakumbo, asi zvinogonawo kuita kuti misi miviri isaputike. Corticosteroids inogona kubatsirawo, kunyange zvazvo inofanira kupiwa zvakanyatsonaka kune avo vane chirwere cheshuga.
Sources:
"NINDS Stiff Person Syndrome Information Page." Matambudziko. 14 Feb 2007. National Institute of Neurological Disorders uye Stroke. http://www.ninds.nih.gov/disorders/stiffperson/stiffperson.htm.
Rodgers-Neame, Nancy. "Stiff Person Syndrome." eMedicine. 20 Mar 2006. WebMD. http://www.emedicine.com/neuro/topic353.htm.
Autoantibodies kusvika ku-128-kd synaptic protein mune vatatu vakadzi vane hutano-murume syndrome uye kenza yemazamu. AU Folli F; Solimena M; Cofiell R; Austoni M; Tallini G; Fassetta G; Bates D; Cartlidge N; Bottazzo GF; Piccolo G; et al. SO N Engl J Med 1993 Feb 25; 328 (8): 546-51
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