Degenerative Brain Disease
Chirwere cheCanavan ndechimwe cheboka rezvirwere zvema genetic zvinonzi leukodystrophies zvinokonzera kukanganisa mu myelin sheath inobata masero emagetsi muuropi. Muhosha yeCanavan, chimiro chetachiona chechiromosome 17 chinokonzera kushayikwa kwe enzyme inonzi aspartoacylase. Pasina iyi enzyme, kusagadzikana kwemakemikari kunoitika kunokonzera kuparadzwa kwemyelin muuropi.
Izvi zvinokonzera utano hwehutano huri nani hunoita kuti huve hunova muzvigunwe zvepongy full filled microscopic-filled fill spaces.
Zvirwere zveCanvan zvinotora nhaka muzvinyorwa zvisinganzwisisiki , zvichireva kuti mwana anofanirwa kugamuchira imwe yeropa yemutumbi kubva mumubereki mumwechete kuti agadzirise chirwere chacho. Kunyange zvazvo chirwere cheKanavan chinogona kuitika mune rimwe remadzinza, rinoitika kakawanda pakati pevaAshkenazi kubva kuPoland, Lithuania, nekumadokero kweRussia, uye pakati peSaudi Arabia.
Zviratidzo
Zviratidzo zvehutano hweKanavan zvinowanikwa muchecheche uye zvinowedzera kuwedzerwa munguva. Dzinogona kusanganisira:
- kuderera kwemisitema tone (hypotonia)
- Utsi hwemitsipa isina simba hunoita kuti urege kutungamirirwa nemusoro
- musoro mukuru usina kukwana (macrocephaly)
- makumbo anochengetedzwa zvisina kukwana (kufungidzirwa)
- tsvina dzemaoko dzinowanzoshandura
- kurasikirwa nemakumbo emotokari
- kuora mwoyo kwepfungwa
- seizures
- bofu
- kudya zvinetso
Kuziva
Kana zviratidzo zvecheche zvinoratidza zvirwere zveKanavan, kuongororwa kwakaverengeka kunogona kuitika kuti zviratidzo zvizivikanwe.
Inonzi computed tomography (CT) scan kana magnetic resonance imaging (MRI) yeuropi inotarisa kuora kwehupi hwehupi. Kuyera ropa kunogona kuitwa kuvhara muoneki inoshaya kana kutsvaga genetic mutation inokonzera chirwere chacho.
Kurapa
Ikoko hakuna mushonga wehutano hweKanavan, saka kurapa kunotarisa pakugadzirisa zviratidzo.
Kurapa kwepanyama, basa, uye kutaura kunogona kubatsira mwana kusvika paanogona kubudirira. Sezvo chirwere cheCanavan chinowedzera kuipa, vana vazhinji vanofa vachiri vaduku (vasati vava nemakore mana), kunyange zvazvo vamwe vanogona kupona vachiri kuyaruka uye makumi maviri.
Genetic Testing
Muna 1998, American College of Obstetricians uye Gynecologists vakagamuchira chigaro chekusimudza vachirumbidza kuti vanachiremba vanopa kuongororwa kwechipatara cheCanavan kuvanhu vose veAshkenazi Jewish background. Munhu anotakura ane imwe yejeni mutation, saka iye haaiti chirwere asi anokwanisa kupfuudza kuchinja kwemajini kune vana. Inofungidzirwa kuti 1 muvanhu makumi mana muAshkenazi yevaJudha inotakura kuchinja kwegene kwechirwere cheKanavan.
Zvinokurudzirwa kuti vakaroorana vari pangozi yekutakura mutenhi inonzi mutated vanoongororwa vasati vatora mwana. Kana zviitiko zvekuedza zvichiratidza kuti vabereki vose vari vatakuri, mazano anopa mazita anogona kupa mamwe mashoko pamusoro pengozi yekuva nemwana ane chirwere cheKanavan. Masangano akawanda echiJudha anopa maitiro ekuongorora zvirwere zveCanavan uye zvimwe zvinetso zvisingawanzoitiki muUnited States, Canada, uye Israel.
Sources:
> "Kanavan Disease." Matambudziko A - Z. 2 July 2008. National Organ for Neurological Disorders uye Stroke.
> "Kanavan Disease." Marudzi eLeukodystrophy. 2 Aug 2007. United Leukodystrophy Foundation.
> "Chii Chinonzi Canavan Zvirwere?" Zvirwere. National-Tay Sachs & Allied Diseases Association.