In sickle cell anemia , iye zvino mishonga yakanakisisa yatinofanira kudzivirira zvinetso inonzi hydroxyurea, dzimwe nguva inopfupiswa HU. Hydroxyurea yakatanga kusimbiswa semishonga chemotherapy muma1960. Yakashandiswa kune zvakasiyana-siyana zvakashata mamiriro ekutanga, asi yakashandiswa mu sickle cell chirwere ikozvino kwemakore anopfuura 25. Hydroxyurea ndiyo chete FDA (Zvokudya uye Drug Administration) inogamuchirwa mishonga yokurapa chikwereti chinonzi anemia.
Ko Hydroxyurea Inoshanda Sei muSirle Cell Anemia?
Muchengetedza seni rinonzi anemia, hydroxyurea inobatsira muviri kubudisa fetal fetal hemoglobin (Hb F). Uyu hemoglobin inowanikwa mumwana achangoberekwa. Vana vachangobva kuberekwa vane sickle cell chirwere havanetseki mumwedzi miviri yekutanga yehupenyu nokuti fetal hemoglobin inodzivirira masero matsvuku eropa kubva pachirwere. Iko kukura mu fetal hemoglobin kunobatsira kuchengetedza sero yako tsvuku yeropa panzvimbo panzvimbo yeirwere. Aya masero matsvuku eropa anokwanisa kuyerera nemishupa yeropa zvakanaka.
Ndezvipi Zvakanakira Hydroxyurea Therapy?
Mune zvidzidzo zvakawanda muvana nevana vakuru vane sickle cell anemia, hydroxyurea kurapwa kwakabatanidzwa nematambudziko mashoma anorwadza, zvishomanana zvechifukidzo chechifu (chirwere chemapapu) zviitiko, kuderedzwa mukudiwa kwekuwedzerwa ropa, nekuderedza kudiwa kwekuchengetwa muzvipatara. Hydroxyurea inowedzerawo hemoglobin, zvichiita kuti uwedzere kupera .
Uyezve, chirwere che hydroxyurea chave chichibatanidzwa nehupenyu hurefu kwenguva refu kuvanhu vakuru vane sickle cell anemia.
Migumisiro Yechiri
Zvichienderana nemitero inoshandiswa mu sickle cell anemia, migumisiro yacho yakaoma. Kusuruvara kwebvudzi, maronda emuromo, uye ngozi yakawedzerwa yehutachiona hunobatanidza chemotherapy haigoni kuonekwa.
Hydroxyurea inogona kuderedza masero eropa rega, hemoglobin, uye maplatelet. Nokuda kweizvi, zvinoita kuti chiremba wako aongorore maonero ako zvakakwana nehuwandu hwehuwandu hwemvere uye reticulocyte count. Dzimwe nguva, kurwadziwa kwepamuviri kunoonekwa asi izvi zvinowanzova zvinyoro uye kugadzirisa pasina kupindira. Chimwe chikamu chekugadzirisa kusvibiswa kwezvipikiri zvinonzi melanonichyia. Muzhinji, varwere vakawanda vanokwanisa kuwana mukana we hydroxyurea vanogona kutsungirira nemamwe madhara.
Ndezvipi Zvirwere Zvinofanira Kuongorora Kurapa Ne Hydroxyurea?
Maererano neyo yakangoshandiswa kare kare magara ekufambisa mirayiridzo kubva kuNational Heart, Lung, uye Blood Institute (chikamu cheNational Institutes of Health) rakabudiswa muna 2014, vana vose vane hemoglobin SS uye sickle beta zero thalassemia vanofanira kupiwa hydroxyurea therapy kudzivirira zvinetso pashure pemwedzi 9 yezera. Muvanhu vakuru, chirwere che hydroxyurea chinofanira kufungidzirwa kune varwere vane 3 kana zvinetso zvinorwadza gore negore, kurwadziwa kunopindira mabasa ezuva nezuva, nhoroondo yemapfupa echipfuva, kana kuti chirwere chakakomba chinopindira chinopesana nemabasa ezuva nezuva.
Hydroxyurea Inoita Kanzera Here?
Nhoroondo yekare, izvi zvave zvakanyanya kunetseka. Varwere pakutanga vanotapwa ne hydroxyurea vaiva nemamiriro ezvinhu akawedzera mungozi yekushaya chirwere (kenza) asi nokuti vakave nekenza panguva ye hydroxurea therapy yaive iyo inonzi iyo mishonga.
Muchirwere chechiremba chechirwere, mhinduro yacho kwete. Maererano nekudzidza kwakabudiswa muna 2014 vachitarisa zvakananga kune varwere vane sickle cell chirwere, avo vakatora hydroxyurea vakanga vasina kuwedzera mungozi yekenza yakaenzaniswa nevaya vasina kutora hydroxyurea.
Ndingatora Hydroxyurea Panguva Yechirwere?
Panguva ino hazvikurudzirwi kutora hydroxyurea panguva yekuzvitakura. Hydroxyurea ikirasi D mapiritsi anoratidza kuti panoita seine ngozi yekukura mwana. Kune nhamba shomanana yezviitiko zvinorondedzera kubata pamuviri kune vakadzi vane sickle cell chirwere vakaramba vachiwedzera hydroxyurea asi mamwe mashoko anodiwa.
Ndinogona Kubvira Ndakarega Kutora Hydroxyurea?
Kwete, hydroxyurea haisi mushonga. Inongoshanda chete kana iwe uchiitora sezvinorayirwa. Hydroxyurea chirwere chisingaperi chine chirwere chisingagumi chakafanana nemishonga vanhu vane huwandu hwemhepo inotora zuva nezuva.
> Sources:
> Castro O, Nouraie M, Oneal P. Hydroxycarbamide Kuchirwa muSickle Cell Disease: Inofungidzirwa Zvingangodaro L eukaemia Risk uye yekuchengetwa kwezvipatara Kuwana Mukana. British Journal yeHematology . 2014; 167: 687-691.
> Ware RE. Mushandisiro Anginoshandisa Hydroxyurea Kuitira Vana Vachiri Kuyaruka. Ropa . 2010; 115 (26): 5300-5311.