Iwe uchangobva kuongororwa ane iron inowedzera (inonziwo hemosiderosis) yechipiri kune dzakawanda dzvuku dzeropa rekuisira ropa iwe waifanira kutambira. Iwe unogona kunge wakazviziva nezvekuisa pangozi pakutanga kweurongwa hwako hwokurapa asi zvichida iwe hauna. Iron inowedzera inogona kukonzera matambudziko akawanda saka zvakakosha kuva nepurogiramu yakanaka yekurapa.
Iron chelators (mishonga inobvisa simbi kubva mumuviri) inowanzoshandiswa kune vanhu vane thalassemia kana mamwe maitiro anemia anoda kazhinji tsvuku yeropa ropa.
Vanhu vane hemochromatosis inorapwa vanobatwa ne serial phlebotomy (muviri kubviswa kweropa).
Iron Chelation Options
Parizvino, muUnited States, kune zvitatu zvakasiyana sedheta chesimbi. Chimwe nechimwe chine zvayo uye zvinotyisa. Zvinhu zvakawanda zvinoremerwa pachisarudza kuti mishonga inoshandisei.
Deferoxamine
Deferoxamine (zita rokuti Deferral) rakashandiswa kwemakore anodarika makumi mana muUnited States. Deferoxamine inogona kupiwa seine intravenous (IV) inokonzerwa kuchipatara asi kazhinji vanhu vane iron yakawandisa vanopa deferoxamine subcutaneously (pasi peganda) kumba. Iko kunokonzerwa kunopiwa maawa masere kusvika pa12 usiku pamashandisi kadiri kadiri inowanikwa pombi. Kushanda kweganda kwemukati kunogona kuitika asi kunogona kurapwa nekuderedza chireji / chiyero chekukanganiswa kana ne hydrocortisone cream.
Vanhu vakawanda vanotsungirira zvakanaka deferoxamine asi nekuda kwekudzivirira kunofanira kupiwa kwenguva yakareba, vanhu vakawanda vaneta nokurapa uku.
Kunzwa uye kana kurasikirwa kworatidzwa kunogona kuitika pamatambo akakwirira, saka paunenge uchirasikirwa ne deferoxamine iwe unofanirwa kuva nekunzwa gore negore nekuona kuonekwa.
Deferasirox
Iyo yakawanda yakawanda iron chelator inoshandiswa muUnited States is deferasirox. Inobatsira pakubvisa simbi kubva pachiropa nemwoyo, nhengo mbiri dzingangodaro dzine dare rinorema.
Deferasirox inowanikwa mumadziro maviri: tablet inopararira (yakapiswa mumvura) inonzi Exjade uye piritsi inogona kumedzwa inonzi Jadenu.
Chimwe chezvinyorwa zvikurusa zve deferasirox ndechokuti inorapwa mishonga inotorwa kamwe chete pazuva. Zvinosuruvarisa, hapana chimiro chemvura che deferasirox. Kunyange zvazvo Jadenu achiuya sezviri nyore kumedza piritsi, vana vakawanda vane anemias vanochengetedzerwa ropa, vachawedzera simbi vasati vava kukwanisa kudya mapiritsi. Muvana ava, Exjade inogona kushandiswa.
Iyo yakaderera kune iyi yekuumbwa ndeyokuti inongonakidza icky. Girafu yacho inopera mumvura asi kazhinji haina kupera zvachose uye mvura inotora inenge yakasvibiswa. Kunwa kunogona kunge kwakagadziriswa zvishoma nokuiisa muapuro kana jisi rearangi. Pane chirwere chinowanzoenderera mberi chiongorori chekuongorora kushandiswa kwemaferesiro e-deferasirox anokwanisa kusaswa pamusoro pekudya. Deferasirox inogonawo kushandiswa kune vanhu vasina kuisira ropa thalassemia vanopfuura makore gumi.
Deferiprone
Deferiprone (Ferriprox) ndiyo yakapfuma iron chelator inobvumirwa muUnited States. Kunyange zvazvo deferiprone iri mushonga wemuromo, ikozvino inotorwa katatu pazuva. Inouya sepiritsi kana mvura. Zvinoratidza deferiprone inogona kuva yakanakisisa mishonga yekubvisa simbi kubva pamwoyo.
Kunyange zvazvo vanhu vakawanda vachiregerera deferiprone pasina nharo, iyo inonyanya kushandiswa nayo yechipatara inonzi agranulocytosis, yakaoma kwazvo neutrophil nhamba dzinogona kuwedzera ngozi yezvirwere. Kunyange paine mishonga iyi, nhamba ye neutrophil inofanira kuteverwa pamwe chete nehuwandu hwemavhiki ese ega (CBC).
Therapy Therapy
Vamwe vanhu vane dare rinorema vangada kurapwa nevanopfuura chekator imwe panguva imwe chete. Izvi zvingave kutora deferasirox kana deferiprone zuva rega rega ne deferoxamine infusions 3 kusvika 4 pavhiki.
Kana uine mibvunzo pamusoro pekunge imwe iron chelator yakakunakira iwe, kurukura nayo nemutengi wako wehutano.
Iva nechokwadi chokuti iwe unotora mushonga sezvaunorayirwa uye uudze chiremba wako nezvezvinetso zvose zvaunazvo.
> Kwakabva:
> Schrier SL uye Bacon BR. Chirwere chechirwere chethalassemia nedzimwe simbi yepamusoro yenyika. > In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA.