Statin Mishonga Inogona Kuita I Gene Kukonzera Uturu Hurwa
Statins iyi iboka rekutsvaira-kupera mishonga inoshandiswa nekuvhara mapuroteni anokosha, HMG-CoA reductase, iyo inokonzera kugadzira cholesterol muropa. Iyi mishonga inobudirira mukuderedza zvirwere uye kushaya mwoyo.
Mamiriyoni eAmerica anotora mitemo nokuti anonyatsogadzirisa zvinhu zvose zvehuwandu hwepombi yako nekuderedza LDL cholesterol uye triglycerides mukusimudza HDL cholesterol.
Zvisinei, kufanana nemishonga yakawanda, pane zvingava nemigumisiro.
Zvimwe zvikanganiso zvemashoko zvinosanganisira:
- kurwadziwa kwemasisita seinovhiringidza
- kuwedzera mukugadzirwa kwemakemikari mukati mechiropa sechiitiko chinowanzo
- tsvina uye chiropa chinokanganisa sechinhu chisingaoneki
- zvinetso zvekudya, kusanganisira gesi, chirwere cheshuga kana kushungurudzika, sechinhu chisingawanzovi
- kuwedzera mune shuga yeropa, iyo inogona kutungamirira kukura kwechirwere cheshuga chechipiri, iduku, asi inogona kuisa pangozi
- reversible neurological side effects, kusanganisira kukanganisa kukanganisa uye kuvhiringidzika, inyevero inobva kuU.S. Food and Drug Administration iyo inowanikwa pamakanyorwa emuraini
A Side Effect of Statins is Muscle Pain
Vanenge 5 kusvika ku10 kubva muzana yevarwere vanotora mazita vanoona zvipatara zvakakosha migumisiro, izvo zvakakwirira kudarika zvinyorwa zvepakutanga. Zviratidzo zvinogona kuonekwa mukati memwedzi mitanhatu yekurapa kana kuonekwa mushure memakore akawanda.
Apo zvinosvika pakurwadziwa kwemasisipo, migumisiro inogona kubuda kubva pamusana musimba utera kusvika kuhupenyu hunotyisa rhabdomyolysis , iyo ishoma.
Dambudziko rako rekurwadziwa kwemasimba kana kutora mitemo kunobva kune zvakasiyana-siyana zvezvinhu, kusanganisira:
- uri pamusoro pe80, mukadzi, kana akaonda
- kunwa mazambiringa mazambiringa
- kuora mvura kana kudhakwa kunwisa
Chidzidzo chakabudiswa mumusangano wa2016 weNew England Medical Journal chinoratidza statin-inoshandiswa autoimmune myopathies inowanzova nemigumisiro yechipimo chemasimoni.
Izvi zvakakomba musimba kuparara kwemamiriro ezvinhu hazviwanzo uye zvinoitika muchikamu chiduku chevarwere.
The Reason Why Statins Cause Muscle Pain
Ongororo dzakapfuura dzinoratidza kuti gene atrogin-1 inotendeuka pamatanho ekutanga ekudengenyeka kwemisumbu (musimba kuparara), iyo inobatanidza nezvirwere zvakadai sekenza , sepsis , uye AIDS . Apo inrogin-1 geni haisi kushanda, musimba kuparara hazviitiki.
Masayendisiti paBheet Israel Deaconess Medical Center muBoston, Massachusetts vakafunga kuti atrogin-1 inogonawo kuita basa mukuvandudza myopathi kune avo vanotora mazita. Kuti vaedze izvi, vaongorori vakapa statin, Mevacor (lovastatin) , kuti vakwanise kutakura masero masero, hove yezbra, nevanhu.
Vatsvakurudzi vakawana kuti vanhu vachitora lovastin vaiva nezvikwata zvepamusoro zve-atrogin-1 kupfuura avo vasingatori mishonga. Iyo yakawanda yeMevacor yakapiwa masero uye hove yezbra, inowanzove yakave iyo kukuvadzwa kwemisungo kwaizoitika. Apo atrogin-1 yakabviswa kubva mumasero, mushonga uyu hauna kukonzera musero kuora.
Iyi ruzivo inotangira, asi inotipa kunzwisisa kwechingave chiri kukonzera marwadzo emasisita mumashandisi emasimoni, uye nei vamwe vanhu vachitora mitemo vangave vanowanzoita izvi kupfuura vamwe.
Mune ramangwana, izvi zvinogona kubvumira mutano wako wehutano kuti aone kana uri pangozi yemamatopati anokonzerwa netsika , kubva pakurwadziwa kwemasumbu kusvika kuhupenyu hwehupenyu hunotyisa.
Uyezve, masayendisiti anogona kukwanisa kushandisa geni iri, kana kuti vamwe vari kubatanidzwa, kudzivirira misi yakakuvara inokonzerwa nemasimoni.
Sources:
Hanai JI, Cao P, Tanksale P, et al. Mutsara-zvakananga ubiquitin ligase atrogin-1 / MAFbx inopindirana nemafungiro emakumbo anonzi toxicity. J Clin Invest. 117 (12): 3940-3951.
Mammen, Andrew. The New England Medical Journal of Medicine: Statin-Associated Autoimmune Myopathies (2016)
Mayo Clinic: Statin Side Effects - Weight Benefits uye Ngozi (2013)