Maitiro Anoshanda Pamwe Pakombiyuta PCOS Dhiyabhorosi Sezvisina Kudiwa Misoro Yemaziso
Polycystic ovary syndrome ( PCOS ), chirwere chinowanzogadzirisa endocrine pakati pevakadzi vane makore ekuberekwa, vane hutachiona hwehutachiona (hukuru hwemahomoni evanhu, sa testosterone) uye oysatory dysfunction.
Zvimwe zvezvinetso zvinotambudza zvikuru vakadzi vane PCOS ruzivo zvinosanganisira bvudzi: kurasikirwa kwebvudzi uye kunyanya bvudzi (hirsutism). Zvigumisiro zvekudzidza zvakabudiswa mu PLOS One, pepanhau rinoongorora-vezera, rakaona kuti hirsutism yakanga ine simba rakasimba pane hutano hwakabatana-hutano hwehupenyu hwevakadzi veIranian vanobatwa neCPOS.
Hazviiti chete kuti migumisiro yehursutism inotora nguva yakawanda yekugadzirisa, inobata hutano hwehupenyu uye kuzviremekedza.
Vakadzi vane PCOS vanotambura nemigumisiro yehursutism vangave vakanyorerwa Flutamide, mushonga unoshanda seanorwisa-androgen.
Kubva sei Flutamide Works
Flutamide (zita rinowanzoitwa Eulexin), rinoshanda nekuvhara uyerogens, iyo iboka rehomoni inobatsira mune zvehutano hwevanhu uye kubereka.
70-80% yevakadzi vane uyerogens dzakawandisa zvinoratidza hirsutism. Androgens inowedzera kukura kwehutsi uye inoshandura pfupi, yakanaka, yakatsvuka, ine bvudzi (vellus bvudzi) kune yakareba, yakareba, uye yakasviba (bvudzi rinogumira). Apo androgens inoderedzwa, hutsva hutsva hukura hunoderedzwa uye kukura kwemvere dzemazuva ekupedzisira kunopera.
Flutamide inovhara androgen receptors pamisoro yebvudzi follicle masero saka androgens haigoni kuwirirana kune zvinogamuchirwa. Apo androgens muvhudzi hwebvudzi dzakadzivirirwa, kupererwa kwebvudzi dzakabatana nePCOS uye hirsutism inoderedza.
Izvi zvinogona kuderedza zviratidzo zvePCOS , kunyanya kubwinya kwebvudzi kunowanikwa neCPOS, kunyange zvazvo Flutamide isina kubvumidzwa neDFA nokuda kwekushandisa.
Vakadzi vazhinji vanotora Flutamide vanocherechedza bvudzi rakanyanya uye vashoma muviri uye vhudzi rezvepiso. Chimwe chinhu chinokonzera Flutamide ndechokuti hachisi chetero-steroidal uye hachina kukanganisa basa repfungwa sevamwe anti-androgens.
Flutamide haina kushanda nokukurumidza. Bvudzi rinokura panguva dzakasiyana uye chikamu chokura chinopesana maererano nenzvimbo yemuviri, kuitira kukura zvakakwana, uku kutenderera kwekukura kunenge mwedzi mina nokuda kwebvudzi. Ichi ndicho chikonzero zvinokurudzirwa kupa anti-androgen therapy kupfuura mwedzi mitanhatu kuti iite zvizere.
Nhamba uye Migumisiro Yechipfuva
Chiitiko cheFututamide chePCOS is 125 mg kana 250 mg capsules maviri kusvika katatu pazuva. Ndapota taura kune chiremba wako mazano kuti uwane muyero wakakwana wemamiriro ako. Nguva dzose tevera mazano echiremba wako usati watanga chero mishonga yemishonga.
Mimwe yemigumisiro yakazara yeFlutamide inosanganisira:
- kugona
- kuora mwoyo
- kuvhiringidzika
- chirwere
- nausea
- kurutsa
- hot flashes
- kurasikirwa kwesibido
- mapundu
- kuzvimba
- ganda rakaoma
- birth defects
Iri haisi rondedzero yakazara yemigumisiro uye vamwe vanogona kuitika. Bvunza chiremba wako kana iwe uchinge uchinge uine chero humwe hwemigumisiro inotevera.
Mamwe Mirayiridzo
Nguva dzose kuongororwa ropa kunokurudzirwa kuti uongorore chiropa uye neropa basa uye kudzivirira doro kubva pakutora Flutamide.
Zvinonyanya kukosha kuti usave nepamuviri panguva yaunotora Flutamide, nekuda kwekukanganisa kunogona kumucheche mwana. Iva nechokwadi chekushandisa maitiro akabudirira ekudzivirira kuberekwa uye usasamwisa paunotora ichi chemishonga.
Rondedzera chero zviitiko zvisingaenzaniswi kune chiremba wako nokukurumidza.
Sources:
Ibanez L, Potau N, Marcos MV, de Zegher F. Kurapa kweHirsutism, Hyperandrogenism, Gligomenorrhea, Dyslipidemia, uye Hyperinsulinism muNobobese, Vasikana Vechidiki: Chiitiko cheFutamide. J Clin Endocrinol Metab. 2000 Sep; 85 (9): 3251-5.
> Mahnaz Bahri Khomami, Fahimeh Ramezani Tehrani, Somayeh Hashemi, Maryam Farahmand, naFereidoun Azizi. Pamusoro pePOSOS Symptoms, Hirsutism Inonyanya Kukoshesa Kwoupenyu Hwevakadzi veIranian. PLoS One. 2015; 10 (4): e0123608.
Muderris II, Bayram F, Guven M. Kuchengetedzwa kweHirsutism Nechepasi-Dose Flutamide (62.5 mg / zuva). Gynecol Endocrinol. 2000 Feb; 14 (1): 38-41.
Muderris II, Bayram F, Guven M. A Inotarisirwa, Ratimized Trial Kuenzanisa Flutamide (250 mg / d) uye Finasteride (5 mg / d) muChirango cheHirsutism. Fertil Steril. 2000 May; 73 (5): 984-7.