A Corticosteroid Yakagadzirirwa Kuderedzwa Kusunungurwa
Rayos ( prednisone ), iyo inozivikanwa seLodotra muEurope, inotanga kusunungurwa-kusunungurwa kwekubudiswa kwema-dose prednisone. Rayos, inogadzirwa naLove Pharma, yakagamuchirwa neU.S. Food and Drug Administration (FDA) musi waJuly 26, 2012, nokuda kwerhumatoid arthritis nezvimwe zviratidzo.
Dhiyabhorosi ye FDA yakabva pane dhesi iyo yakaenzanisa ne pharmacokinetics (kureva, iyo mishonga inobatwa sei, inogadziriswa, yakabviswa) yaRayos kuenda kusununguka-kusunungurwa prednisone, pamwe nemashoko kubva ku Circadian Administration yePrednisone mu RA (CAPRA-1 ne2 ) miedzo.
CAPRA-2 yakaratidza kuti vanhu vane muongorori wehutachi hutatoid arthritis avo vaibatwa naRayos vakawana kuwedzera kwekuwedzera mumatongerwo emuitiro ACR20 kuenzanisa ne placebo, uyewo kuwedzera kukuru muhutano hwekuneta. CAPRA-1 yakaongororwa kusachengetedzwa kwakazara kwaRayos.
Zviratidzo
Rayos inonzi corticosteroid ine-anti-inflammatory kana immunosuppressive zvinoshandiswa kurapa zvimwe zvinokonzera, dermatologic, endocrine, masimba, hematologic, neoplastic, nervous system, ophthalmologic, renal, respiratory, uye rheumatologic.
Nezve rheumatologic mamiriro, Rayos inogona kushandiswa pakurwirwa kwenguva pfupi kwechiitiko chakaoma che gouty arthritis. Rayos inogonawo kushandiswa mune dzimwe nyaya dze ankylosing spondylitis , dermatomyositis, polymyositis, polymyalgia rheumatica , psoriatic arthritis , kudzokerazve kwepolchondritis, rheumatoid arthritis, Sjogren's syndrome , systemic lupus erythematosus , uye vasculitis .
Kuwanika
Rayos inowanikwa se 1 mg., 2 mg., Uye 5 mg. tarisiro-kusunungurwa piritsi.
Kusarudza
Kusarudzwa kunofanira kuve mumwe nomumwe nekufungisisa kwakapiwa zvirwere zvakanyanya uye kana varwere vari kushandisa ikozvino-release prednisone. Nhamba yekutanga inowanzoita 5 mg. raRayos kamwe pazuva. Zvisinei, varwere iye zvino pa prednisone vangada kuchinjwa kwechirwere kuti vaite zvakaenzana kana vachisvika kuRayos.
Rayos inofanira kutorwa nechingwa, uye tablet racho inofanira kutorwa. Nekuchengetedza, chirwere chakanyanya kuderera chinofanira kushandiswa. Kurambidza kunofanira kunge kuri kuwedzera.
Zvakaipa Kuchinja
Kushandurwa kwakaipisisa kunowanzobatanidzwa ne-corticosteroid kusanganisira kushandiswa kwemvura, kukwirira kweropa, kushanduka mukati mekushushikana kweglucose, mafungiro ekuchinja, kuwedzera kuwanda, nekuwedzera kudya.
Pane zvimwe zvinopikisa zvinogona kuitika zvinosanganiswa nenhengo dzakawanda dzomuviri wemiviri. Zvose zvakanyatsorondedzera ruzivo rweRayos zvine rondedzero yakazara. Maitiro anonzi Musculoskeletal anowanzobatanidzwa ne corticosteroids anosanganisira osteonecrosis yevakadzi uye humeral heads, osteoporosis , musimba utera, kurasikirwa kwemaviri, masimba ekuputsika kwemafupa, uye tendon rupture.
Contraindications
Rayos haafaniri kushandiswa nevarwere vane hunozivikanwa hwe hypersensitivity kune prednisone kana zvimwe zvisingabatsiri zvinoshandiswa zviri muhwendefa.
Manyevero
- Varwere, zvikuru avo avo vanorapwa ne prednisone kwenguva yakareba, vanofanira kuongororwa nekuda kwe hypothalamic-pituitary-adrenal axis kuderedza, chirwere Cushing's, uye hyperglycemia.
- Ikoko kuwedzerwa kwekuwedzera kune hutachiona hutsva uye kuwedzera njodzi yekuwedzerwa kana kuedzazve kugadziriswa kwemazuva ano kune varwere vanobatwa naRayos kana prednisone.
- Ropa, uye sodium uye potasium dzinofanirwa kuongororwa.Mishonga inogona kukanganisa munyu nekuchengetwa kwemvura.
- Iko kune ngozi yakawedzerwa yekuora kwemimba, kusanganisira kupera. Zviratidzo zvinogona kuvharwa.
- Euphoria, kusuruvara, kuchinja mafungiro, hupenyu hunochinja, uye kuora mwoyo kwakanyanya kunogona kuitika. Kusagadzikana kwepfungwa kunogara kunogona kukura nekushandiswa kwet prednisone.
- Kuderedza kuwedzera kwepafupa kunogona kuitika.
- Ikoko kunogona kuva nehutachiona zvinokonzera kusanganisira cataracts, glaucoma, uye utachiona.
- Urarame kana kurarama zvirwere zveattenuated hazvifaniri kupiwa kuvarwere vanotora immunosuppressive dose ya prednisone.
- Kurwadza kwechirwere kunogona kuitika mukati mekutanga kwekutanga kwekuita pamuviri.
Kubatana Kwemishonga
Rayos angataurirana na:
- Anticoagulants
- Anti-diabetes mishonga
- CYP3A4 inducers uye inhibitors
- Cyclosporine
- NSAIDs (nonsteroidal anti-inflammatory drugs)
Iva nechokwadi chokuti chiremba wako anoziva mishonga yose uye zvinowedzera iwe ikozvino kutora. Zvakakosha kuongorora njodzi inogona kuenzaniswa nekugona kubatsirwa kwekurapa naRayos.
Chii chakasiyana?
Rayos anokasiyana sei ne-prednisone-kusunungurwa? Mumakiriniki, Rayos aibatanidzwa panguva yegumi nemasere ane zvokudya. Kuzononoka-kusunungurwa kwaRayos kwakabvumira kuti kurapa kwema prednisone muropa kuitike apo maitiro e- cytokine akatanga kuwedzera mukati meusiku. Iyi nzira yekugadzirisa inogona kupa huri nani hwekudzivirira kune vamwe varwere.
Sources
Rayos. Kunyora Mashoko.
http://www.rayosrx.com/PI/RAYOS-Kutsanangura-Information.pdf
Horizon Pharma Inozivisa FDA Chibvumirano cheRAYOS® (prednisone) Dhairiro Dzakabudiswa Dhetetiyumu Arthritis uye Mamwe Mamwe Mazano Anowedzera. Horizon Pharma. July 2012.
http://ir.horizon-pharma.com/releasedetail.cfm?ReleaseID=695983