Kusiyana mu Mini Transplant uye Growth vs Malignancy Effect
Zvisiri-myeloablative stem cell transplants, kana "mini-transplants," iyo inenge ichangobva kuwanikwa yeallogeneic peripheral stem cell transplant iyo haifaniri kubvisa (kuchenesa) marora kusvika pachiyero chetsika chemasero chetachiona.
Maitiro Avanoita
Muchidimbu stem cell transplants, varwere vanopiwa zvikwereti zvakanyanya zvekemotherapy, kana kana pasina mihizha, kuparadza, kana "ablate," marrow.
Zvadaro vanopiwa kuvharwa kwemasero ekudzivirira masero kuti vadzosere kushandiswa kwesero reropa nekuchengetedzwa kwezvirwere.
Kutsvakurudza kwakaratidza kuti maitiro akawandisa emakemikrasi uye mazai anopiwa muzvigaro zve stem cell transplants zvingasava chinhu chimwe chete chinokonzera kubudirira kwavo mukukanganiswa kwekenza. Zvisiri-myeloablative stem cell transplants zvinoshandisa zvishoma zvishoma madhemotherapy kuti zvibudirire.
Graft vs. Malignancy
Nheyo inobva kumashure kunogona kubudirira kwerudzi urwu rwekutsvaira kunonzi "graft-against-malignancy" (GVM), "kubatanidza-kurwisa-tumori," kana "kubatanidza-ne-reukemukari". Kana kamwechete masero emadzipa anopa muganhu achiiswa mukati memubatsiri, "mutsva" wezvirwere zvemuviri unoziva kuti chero sarudzo dzese dzinoramba dzichirwisa uye dzinovaparadza.
Kusiyanisa Kubva Memeablative Stem Cell Transplants
Zvisizvo zvisipo-myeloablative transplants zvinopesana zvakanyanya pane zvinoitika musati wapera. Inofananidzwa nemamirovlative transplants, mini-transplants vanoshandisa zvikamu zvakaderera uye zvisinganyanyi kuderedza chemotherapy uye miviri, inoteverwa nekudzikiswa kwemasero ekudzivirira masero.
Izvi zvinotora zvinoshandiswa nehuwandu hwemarignancy chaiyo kana isinganyanyi kutyisa kune mupikiri.
Sezvo nemasikirwo emasero echitema, kuchinja kwemasikati kunotakurawo mukana wekubatanidza nekusangana nechirwere , umo mairi masero anotemwa anoona masero ako sekunze uye kurwisa.
Zvishandiso
Izvi zvinogona kunge zvakasarudzwa kune varwere vakwegura kana kuti vane zvimwe zvirwere zvinogona kuita kuti vasakwanise kubvumira chemheyo inokonzerwa nemigumisiro yenguva dzose.
Zvisiri-myeloablative stem cell transplant zvinogonawo kuva nechinangwa mukurapa varwere vari mukuregererwa nekenza yakawandisa, yakadai seyakanyanya myelogenous leukemia , kana kuti vakadzokerazve shure kwepakutanga stem cell transplant.
Vatsvakurudzi vari kutarisa kubudirira kwekusava myeloablative stem cell transplant kune varwere vane hutano hwakasimba hwekenza, dzakadai sezamu nehvo, pamwe chete nedzimwe mamiriro ezvehutano zvakadai sa multiple sclerosis.
Sezvo zvinotora nguva shoma kuti masero anopiwa awedzere, izvi zvinowanzoshandiswa kana kenza iri mumatanho ayo akareba zvikuru.
Kubudirira
Zvisizvo zvisipo-myeloablative transplants zvakashandiswa kurapa marudzi akasiyana-siyana emaronda eropa, anosanganisira Hodgkin uye kwete-Hodgkin lymphoma, myeloma , uye leukemia. Mhinduro dzekupindura dzakasiyana mune zvidzidzo.
Iyi ndiyo nzira itsva, uye yekutanga ichiitwa pasi pemakore makumi maviri apfuura, saka kune nguva shoma yekutsvakurudza inowanika kune zvipo uye njodzi dzinobatanidza nehuwandu hwekutsvaga. Zvisinei, zvibereko zvekutanga zvinopa tariro kuvarwere avo vangave vasina kukwanisa kugamuchira stem cell transplant , zvikuru iyo iyo iri pakati pemakore makumi mashanu ne75.
Sources:
Neiss, D., Duffy, K. "Mazano Okutanga Okudhinda" muZezone, S. (2004) Hematopoietic Stem Cell Transplantation: Bhuku Rekudzidzisa Vana. Oncology Nursing Society. Pittsburg, PA (pp.13-21).
Duke Medicine. Ropa Rakura uye Marrow Kubika. Nonablative Allogeneic Patient Transplant Handbook. https://www.dukemedicine.org/sites/www.dukemedicine.org/files/nonmyeloablative_allogeneic_transplant_patient_handbook.pdf
Kasamon, Y., Bolanos-Meade, J., Prince, G. et al. Migumisiro yeAngemyeloablative HLA-Haploidentical Ropa kana Marrow Kudyarwa neHome-Dose Post-Kuisa Cyclophosphamide muVakuru Vakuru. Nyaya yeCliniki Oncology . August 10, 2015. (Yakabudiswa paIndaneti tisati tanyora).