Chii Chinokonzera Graft vs Host Disease uye Inogona Kudziviswa Here?
Chirwere chinonzi graft versus host (GVHD) chii, nei zvichiitika, chinoshandiswa sei, uye chinogona kudziviswa here?
Graft versus Host Disease (GVHD) - Tsanangudzo
Graft versus host disease (GVHD) inowanzovhiringidza rutivi rweallogeneic bone marrow kana stem cell transplants . Kunyange zvazvo mikana yekudzikisa GVHD yakasiyana, 40% kusvika ku80% yevakagadziriswa vanofambisa vanowana GVHD mune imwe nzira kana imwe.
GVHD inowanzova nyoro, asi dzimwe nguva inogona kuva yakaoma zvakakwana kuti upenyu huve pangozi. Ichi chinyorwa chichakutora iwe kuburikidza nheyo dzeiyi inokosha uye inogona kuvhiringidza rutivi rwekutsvaira kwekuisa.
Zvinokonzera - Sei Girafu Inoenderana neHondo Dambudziko (GVHD) Inoitika?
Marora kana masero emukati anoiswa mumurwere ane masero eropa omubatsiri. Imwe yeropa remazi riripo mumasero eropa anopiwa ndiro T cell (kana kuti T lymphocyte.) T masero ane masimba masero muzvirwere zvekuzvidzivirira zvinoshungurudza zvakadai semabhakitiriya nemavirusi nemamwe masero ekunze nekurwisa. Dambudziko nekugadziriswa nderokuti iyo masero ekupa T aya anoona masero mumugamuchiri seari kunze kwenyika. Nokudaro mupi (masero ekubatanidza) anorwisa mupikiri (iye ari mukuru wekutsvaga.)
Pamberi pekufambisa kwaitwa, vatsigiri uye vanogadziriswa vanoita HLA vanofananidza kuderedza mukana wekurwisa uku, kunyange kunze kwekuti mutsara wacho wakafanana (somuenzaniso, kubva kune rimwe rakafanana) pane nguva dzose mukana wekuvandudza GVHD.
Ndezvipi zviratidzo zveGraft Versus Host Disease (GVHD)?
Zviratidzo zvinowanzozivikanwa zveGVHDdepend inenge iri yakaoma (kutanga) kana isingaperi (yakapera) kuita.
- Zvakanaka GVHD - GVHD yakajeka inoitika mukati memazuva zana ekugadziriswa uye kakawanda inobata ganda (mashizha,) matumbo, uye chiropa. Vanhu vangave vaine hushu hukuru pane zvamaoko avo uye zvigaro, uye zvikamu zveganda zvingatowedzera. Kubatanidzwa kwematumbo kunogona kukonzera kushungurudza, kusuruvara kwepamu, uye chirwere, asi kubatana kwechiropa kunowanzokonzera jaundice - kuchena kwechivara cheganda.
- GVHD isingaperi - GVH DHIV inowanikwa mushure memazuva zana uye inogona kunge yakabatana kana isingaenderani neGVHD yakaoma. Izvo zvinowanzoitika kakawanda kune vanhu vakave nekugadzirisa maitiro. GVHD isingaperi inowanzokonzera nzvimbo dzakawanda dzomuviri. Pamusoro pekubatanidzwa kweganda, maronda, uye chiropa sezvinoitwa maitiro akaoma, GVHD isingaperi inowanzobatanidza maziso akaoma kana maonero anochinja, marwadzo nekuoma mukati memajoini, ganda rinomesa uye kuwedzera pamwe nekudzima, uye kuneta, kushaya simba uye kusuruvara kusingaperi . Zviratidzo zvinogara kwenguva refu zvinogona kuva nemigumisiro yakareba kwenguva yakareba pamusoro poutano hwakanaka uye hupenyu hwehupenyu.
Ko Graft Versus Host Disease (GVHD) Inodziviswa Here?
GVHD imamiriro ezvinhu anogona kunge ari kunetseka zvikuru, uye kubudirira kana kukundikana kwekugadzirwa kunobatsira zvikuru pakudzivirira kana kuderedza kushata kwemamiriro ezvinhu aya. Kune nzira dzakasiyana-siyana dzinoita kuti mukana weGVHD uderedzwe. Izvi zvinosanganisira HLA yakatarisana , kushandisa zvinodhaka kuderedza GVHD, uye kubvisa masero eT kubva muropa remupiro. Nokuda kwechimwe chikonzero, zvisinei, kubvisa masero eT anogona kuva nemigumisiro yakaipa pakubudirira kwekutsvaga mune dzimwe nzira.
Kunyatsotarisira zviratidzo zvokutanga zveGVHD zvinogona kubatsira zvakare, kunyanya kuchenjerera nekubuda kwezuva, sezvo ichi ichiita sechinotyisa chekuwedzera GVHD.
Ko Graft Versus Host Disease (GVHD) Inotarirwa sei?
GVHD haisi nyore kubata. Inosanganisira kuongorora uye kugadziriswa kwemishonga inowanzopiwa nekuda kweGVHD. Inosanganisirawo kuwedzera mishonga mitsva, kunyanya steroids, kumira kukanganisa kune nhengo dzomupiki wekuisa. Dzimwe nguva, kana steroids isingakwanisi kudzora mamiriro acho ezvinhu, mamwe madhiragi angada kuwedzerwa.
Sources:
Bayraktar, U., uye J. Nates. Zvinyorwa zvekuchengetedza zvakanyanya muvanhu vakuru vane hematopoietic stem cell transplantation varwere. World Journal of Clinical Oncology . 2016. 7 (1): 98-105.
Chao, N. Clinical manifestations, diagnostic, uye kugoverwa kwechirwere chinonzi acute-versus-graft. Updated 05/04/15. http://www.uptodate.com/contents/clinical-manifestations-diagnosis-and-grading-of-acute-graft-versus-host-disease