Inobatanidzwa Nechipfuva Izvo Zvinopesana Nemitemo Iyi?
Vamwe vatsvakurudzi vanofungidzira kuti chisingagumi kuneta chirwere (CFS kana ME / CFS ) uye fibromyalgia (FMS) inogona kuva nechikonzero chakafanana. Mumwe mutsvakurudzi anoti chikonzero chacho ndric nitric oxide uye kuti inewo inokonzera multiple chemical sensitivity (MCS) uye mushure mekutambudzika kwepfungwa (PTSD).
Martin Pall, PHD, ndiye purofesa we microbiology paWashington State University uye akatanga kutarisa kuMe / CFS mushure mokunge aonekwa kuti ane.
Chinokosha chepfungwa yake ndeyekuti kwenguva pfupi kushungurudzika kunokonzera kuumbwa kwe nitric oxide inowanzoitika, iyo inotanga kukanganisa uye inoendesa kurwara kwenguva refu.
Zvakakosha kuyeuka kuti iyi protocol inoedza uye haisati yasimbiswa nesayenzi. Nhamba inowedzera yezviongorori, zvisinei, inotsigira dzidziso yehutachiona hwehutachiona hunokwira, uye vamwe vanhu vakaedza purotiti vanoti yakashanda kwavari.
Mashoko aya haafaniri kutarisirwa kana kutsigira pfungwa yaPall asi ari pano kuti akuzivise nezvezvinhu zviripo zviripo uye zvirongwa zvekurapa kuitira kuti iwe ugone kuita zvisarudzo zvakajeka. Zvakakosha kuisa chiremba wako muzvisarudzo zvako zvekurapa uye kuongororwa chero shanduko kune utano hwako.
Nitric Oxide Muviri Wako
Nitric oxide (NO) yakazara mumuviri wako uye inotamba mitoro inokosha yakadai sekukonzera kutakura okisijeni kumatumbu ako uye kutumira pfungwa dzenzara.
Kusvikira kwekupedzisira kwema1990, zvisinei, iyo yainzi inotinha nePall inofunga kuti iyo inonyanya mumhanzi yake. Ongororo dzakawanda dzinoratidza kuchinja kune hurumende zvirongwa zvevanhu vane FMS naM ME / CFS, uye Pall vanoti izvo zvinoshandiswa zvinoda huwandu hwakawanda hweUN.
Pall inoti kumusoro HERE hapana maitiro ari mukati megadziriro yenyoka, zvakare, inotungamirira kumazinga akakwirira e-peroxynitrite, anokonzera kukanganisa kwechivi.
Iwe unowedzera sei HU mu mumuviri wako? Pall inoratidzira 12 inokonzerwa nekudzvinyirira, 8 iyo inotungamirira kukuwedzera zvakananga, 4 iyo inotungamirira kune isina kuratidzika. Kunyanya kunetseka ndezvekuti:
- Utachiona hweHIV (ME / CFS, FMS)
- Utachiona hwehutachiona (ME / CFS, FMS)
- Kutambudzika kwepanyama (ME / CFS, FMS, PTSD)
- Carbon monoxide exposure (ME / CFS)
- Organophosphorus pesticide exposure (ME / CFS, MCS)
- Utachiona hweToxoplasmosis (ME / CFS)
- Mhepo ine simba inokonzerwa nehutachiona (MCS)
- Zvirwere zvinodzivirira (secondary FMS)
Zvimwe zvinokonzera 4 zvinokonzera mhinduro inotora kuwedzera basa reNMDA rekugamuchira, iro rinozivikanwa kuwedzera mazinga e NO uye peroxynitrite (ONOO-). (NMDA receptors inotumira zviratidzo muuropi uye inogona kubatanidzwa mumusero.) Izvi zvinonetsa ndezvi:
- Kuwedzera mupfungwa mupfungwa (FMS, PTSD)
- Ciguatoxin exposure (kubva kune zvekudya zvegungwa) (ME / CFS)
- Organochlorine pesticides (MCS)
- Pyrethroid pesticides (MCS)
Cherechedza: HERE mizinga inowedzerawo semigumisiro yezvimwe zvinhu zvakanaka, zvakadai apo paunoshandisa muviri, idya kudya kwemafuta, kuvandudza chikafu chako kana kurega kusvuta, izvo zvese nyanzvi dzinoona kubatsirwa kune vanhu vane FMS naM ME / CFS. Vatsvakurudzi vazhinji vanofunga kuti hakuna huno hutano hwakanaka hunoita hutano hwako.
Icho Chikuvadza
Pall inotaura kuti kana kushungurudzika kunokonzera kuvakwa kweUN, inotungamirira kufamba kwakashata kunosanganisira maitiro akawanda okuzvidzivirira.
Kubva ipapo, inowedzera unyanzvi uye yakaoma kunzwisisa kunze kwekuti iwe unonyatsoziva nezvehupenyu hwehupenyu. Kana iwe uri, Pall ane mufananidzo wakakwana pawebsite yake. Kune vamwe vose, heino muenzaniso wekuti imwe chete-nhanho yekuti-loop inoshanda sei:
- Pamusoro HERE hapana inowedzera peroxynitrite level;
- Peroxynitrite inowedzera inokonzera kushushikana kwehupombwe (a kuvaka ma molecule anokanganisa masero. Studies inobatanidza kushungurudzika kwehupombwe kune ME / CFS);
- Kushushikana kwepfungwa kunokonzera NF-kB (iyo inodzora kutaura kwemajeni anobatanidzwa mukuzvidzivirira uye mashandisirwo emagetsi);
- NF-kB inowedzera kubudisa kwe enzyme iNOS (inducible nitric oxide synthase);
- NOS inowedzera HERE nhamba, uye tiri kudzoka kuti titevere rimwe.
Pall akambotaura nezvenyaya yakaipa iyo NO / ONOO- mhepo (inonzi "kwete, oh kwete!"). Anoti zvinowanzoitika pamasero emasero, ndicho chikonzero chimwe chimiro chinogona kuva mukurwadziwa apo izvo zvakapoteredza zvakanaka. Inotsanangurawo kuti sei zviratidzo zvinogona kusiyana zvakasiyana-siyana kubva kune mumwe munhu kune mumwe.
Zviratidzo Zvakagoverwa
Pall anoti zvikamu zve NO / ONOO- mutsara zvinogona kutsanangura huzhinji hwezviratidzo zvakagoverwa neCFS, FMS, MCS uye PTSD. (Anovapa sezvikonzero zvinokonzerwa, kwete zvisimbiso.) Zviratidzo izvi zvinosanganisira:
- Kudzidza nekuyeuka kusashanda,
- Kuneta uye kukanganisa kurara,
- Kugara kunorwadza zvakanyanya,
- Kuora mwoyo uye kuzvidya mwoyo / panic attack,
- Immune dysfunction,
- Irritable bowel syndrome,
- Zvokudya zvekudya,
- Kuvhiringidzika kweOrststatic / hypotension (kudonha muropa reropa apo iwe wakamira izvo zvinokuita uchinonoka.)
Kuputsa Mukana
Kuti aputse kupoteredza, Pall anoti inofanira kunge iri "pasi kutongerwa," izvo zvinoreva kurega kuidzikisa nekubvisa zvinhu zvinotungamirira. Somuenzaniso, kana kushungurudzika kuchiita kuti uwedzere kukura, kunoda kuderedzwa kana kutarisirwa. Kupfuura izvozvo, anotenda kusanzwisisika kwemuitiro kunoda mhando dzemhando dzekurapa.
Pepa raPall pane NO / ONOO- rondedzero rinotsanangura zvinhu zvakawanda - zvizhinji zvezvokudya zvinowedzera - kuti anofanotaura zvichadzika pasi kutonga. (Yeuka kuti iyi nheyo haisati yavharwa uye avo vanobatanidzwa vasingatauri kurapa boka iri rezvirwere.) Anonyorawo mitemo yekurapa inoshandiswa navanachiremba vashanu vakawana kubudirira kurapa imwechete kana yakawanda yemamiriro aya uye vanoti marapirwo ose angangoderera kudzora kutenderera. Sezvo nemasarudzo ose ekurapa, unofanira kutaura nachiremba wako maererano nezvakakunakira iwe.
Pall haisi yega inotarisa nitric oxide sechikonzero chinokonzera zvirwere izvi. Vanotsvakurudza vanoverengeka vachiongorora HONO basa, kunyanya mu fibromyalgia, vari kukumbira kuti zvidzidzo zvive kana antioxidants inoshanda kurapa.
Tsvakurudzo
Sezvo bhuku raPall rinotsanangura dzidziso yake yakabuda mugore ra2007, yakawanda tsvakurudzo yakaitwa pane basa re nitric oxide mumamiriro aya.
Muna ME / CFS, zvidzidzo zvakawanda (Sachdeva, Kumar, Gupta) vakaonekwa kuti vatsigire dzidziso yacho, kunyanya mumagetsi-mhando.
Zvimwe zvidzidzo zvevanhu zvinokweretesa kubvuma, kusanganisira chidzidzo che2010 (Suarez) chakaratidzika chisina kujairika CHAVASAMABOLITI mushure mekuvhidzira mune ME / CFS. Tsvakurudzo yakabudiswa muna 2014 (Morris) inoratidza kuti hutachiona uye nitrosative kushushikana kunogona kukonzera zvirwere zvekuzvidzivirira uye zvisingagadziriswi zvinotsigira zvirwere zvechirwere chacho.
Zvisinei, zvidzidzo chimwe chete (Meeus) hazviwani kuwirirana pakati pehuwandu hweHANA muropa nemabasa muna ME / CFS.
Dzidzo dzinoverengeka (Cimen, Fatima, Sendur) dzinotsigirawo dzidziso ye nitric oxide kupinda muFMS. Mumwe (Kim) haana kuwana misiyano yakakura muHATI mazinga pakati peboka reFMS nehutano hwakanaka.
Ndiyo Pall Protocol Yakakodzera Kwako Here?
Iwe chete iwe unogona kusarudza kuti ndeupi mushonga wakakodzera iwe, uye iwe unofanirwa kuva nechokwadi chekukurukura maitiro ako ekurapa nechiremba wako. Mukuwedzera kune zvizhinji zvezvikamu zvemurairo uyu unoda kuti chiremba ave nekutora chikamu, iwe unofanirwa kunyatsoongororwa kuti uone kuti kurapwa hakugoni kukanganisa hutano hwako.
Sources:
Cimen OB, et al. Pain medicine. 2009 Jul-Aug; 10 (5): 813-8. Arginase, mabasa eOS, uye kliniki inoshandiswa nevarwere ve fibromyalgia.
Fatima G, Das SK, Mahdi AA. Clinical uye test rheumatology. 2013 Nov-Dec; 31 (6 Suppl 79): S128-33. Oxidative stress and antioxidative parameters nesimbi yoni inogutsikana nevarwere vane fibromyalgia syndrome: zvinoreva mumapathogenesis echirwere.
Gupta A, Vij G, Chopra K. Journal of neuroimmunology. 2010 Sep 14; 226 (1-2): 3-7. Nzvimbo inogona kuitika yekushushikana kwehutachiona uye immunological activation mu mouse muenzaniso wekusagadzikana kwehutano syndrome uye ita ttenuation nemuorivhi wemuorivhi.
Kim SK, et al. Clinical uye test rheumatology. 2010 Nov-Dec; 28 (6 Zvinyorwa 63): S71-7. Kuoma kwechibhakera uye zvinokonzera zvinonzi cytokines mu fibromyalgia syndrome.
Kumar A, et al. Indian journal of pharmacology. 2011 May; 43 (3): 324-9. Nitric oxide modulation muzvidziviriro zvekuchengetedza kuzvirambidza kune chirwere chisingaperi chinopera simba muzvipukanana.
Martin L. Pall, Chikoro cheMorecular Biosciences, Washington State University. Kodzero dzose dzakachengetedzwa. "Novel Disease Paradigm Inoburitsa Tsanangudzo yeboka rose rezvirwere."
Meeus M, et al. In vivo. 2010 Nov-Dec; 24 (6): 865-9. Nitric oxide maitiro akajairika uye asingabatanidzwi nehutano hwemabasa muhutano hwekushushikana kwehutano: a-case-control study.
Morris G, Maes M. Iye zvino neuropharmacology. 2014 Mar; 12 (2): 168-85. Oxidative uye nitrosative kushungurudzika uye zvirwere zvekudzivirira muviri zvirwere mune varwere vane myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS).
Sachdeva AK, Kuhad A, Chopra K. Brain chikwata chekuongorora. 2011 Oct 10; 86 (3-4): 165-72. Epigallocatechin gallate inogadzirisa zvinokonzerwa nehutachiona uye zvehupenyu muhutori hwomukati wekutakura-kunokonzera kusingaperi kuneta kwechirwere.
Sendur OF, et al. Rheumatology international. 2009 Apr; 29 (6): 629-33. Serum antioxidants uye nitric oxide maitiro mu fibromyalgia: chidzidzo chinodzorwa.
Suarez A, et al. Nyaya yehutano hwevakadzi. 2010 Jun; 19 (6): 1073-7. Nitric oxide metabolite kubudiswa panguva yekurovedza muviri musingagumi kuneta muviri.