Histamine inonzi makemikari inowanikwa uye yakasunungurwa nemasero mashoma anogona kutungamirira kune dzimwe zviratidzo zvichienderana nenhengo yemuviri apo histamine yakabudiswa inoitika:
- Nzeve: runny mphu
- Meso: chinotyisa, mvura
- Nyota: yakaipa, yakaoma
- Mhembwe: kuputika , chifuva chisimbiso , kuperevedza kwefema , nekukwevera
Zvakaitika kare zvakashanda sei
Histamine inopikisa mumiririri wehurumende kana, zvinongori nyore, ikemikisi mutumwa inobatsira kutungamirira mhinduro yako mumuviri kune imwe nyika inopinda.
Histamine inoudza muviri wako masimba ekudzivirirwa maitiro maitiro ekuita kune chimwe chinhu icho chinoona sokune imwe nyika. Muchirwere uye kushaya muviri, muviri wako unopedza kugadzirisa pane chimwe chinhu chisina kukuvadza zvikuru asi chakaita kuti muviri wako wekuzvidzivirira utaure. Histamine inoshanda semotokari yekukurukurirana pakati pezvikamu zvakasiyana zvezvirwere zvemuviri.
Muhutema, histamine inokurudzira bronchoconstriction uye kugadzirwa kwemukoko.
Ndeipi Inzvimbo Yakabva?
Histamine inosunungurwa kubva mumasero mashoma uye basophils apo iwe unotarisana nezvinokonzera. Apo histamine inosunungurwa, mhinduro inotenderera inotanga. Antihistamine zvinodhaka zvinoshandiswa mukurapa kwezvinokonzera zvirwere zvinokonzerwa nokusunungurwa kwe histamine. Mimwe mishonga inorwisa anti-histamine inosanganisira:
- Zyrtec
- Allegra
- Claritin
- Benadryl
Leukotriene Kuchinja Zvinodhaka
Imwe kirasi yemishonga inotaura nezvemimwe yemigumisiro ye histamine ndiyo yeukotriene modifiers.
Iyi mishonga inoderedza bronchoconstriction uye inowedzera kukonzera mumucheka uye kuwedzera kuderedza edema kana kupfugama pamwe nekugadzirwa kweeosinophils sechikamu chepathophysiology yemafi.
Iyi mishonga inonyatsorambidzwa nevarwere uye zvidzidzo zvakawanda zvinorondedzera kubata kwakanaka kune izvi kurapwa zvichienzaniswa nezvimwe zvirwere zvechirwere.
Yakawanda yemabhuku avo emishonga inokurudzira nguva nenguva mapapu ekuedza kuongorora, izvo zvinofanira kunge zvatova chikamu cherongwa hwekuchengeta mweya wako. Uyezve, pane humwe hutano hwakakosha pamwe neropa rakapfava warfarin pamwe nekuchinja kwehutano kunoonekwa mumakore ekuyaruka. Kunyange zvazvo kuora mwoyo kwakaratidzwa kakawanda mukurapwa kwevechiri kuyaruka, pakanga pasina kuwedzera kwevanhu chaivo kuzviuraya kwakataurwa.
Ongororo dzakawanda dzakaratidza marathidilatory effect pamwe nekuvandudzika kwezviratidzo zvechirwere. Zvimwe zvakakosha zvinogadzirisa matanho zvakaratidza kushandiswa kuderera kwekuponesa inhalers , pamwe nekuderera kwekuwedzera kwechibhakera uye zvikamu zvinoda muromo steroid sezvakaitwa prednisone . Zvisinei, mishonga iyi haifaniri kunge yakakosha seyoti inhaled steroids ye astmma yako. Tsvakurudzo dzinoverengeka dzakasiyana dzakaratidza kuvandudzwa mumapapu ekushanda zvakakwirira uye steroid inhayiwa, zvishoma nezvishoma zvinowedzera, uye varwere vanowana mamwe mazuva asina zviratidzo. Somugumisiro, mazano ehurumende anonyatsoratidza kuti steroids inhaled as first treatment line apo iwe unoda zvakawanda pane kuponesa inhaler.
Zvinonyatsozivikanwa kuti kurindira kwevarwere kune slideid inhaled inowedzera, uye nyanzvi dzakawanda dzakaratidza kushingirira kwakasimba kune kamwechete-zuva rimwe nerimwe montelukast uchienzanisa nesteroid inhaled muvana nevakuru.
Vabereki vanowanetseka nezvemigumisiro yemigumisiro ye-steroid inhaled uye ivo vanowanzotarisirwa nevarapi.
Kubatana kwakanyanya kune montelukast kunogona kurondedzera yakaenzana nayo inobatsira inobatsira pamusoro pekudzivirira kweAsthma kune avo veGC yakavhiringidza mune dzimwe "zvinyorwa-nyika" zvidzidzo. Pasinei nekukosha kweizvi mune zvekurapa, zvinonyanya kukanganiswa mumakiriniro emakiriniki, zvidzidzo zvinotungamirira kuvhidhiyo kugamuchirwa neDDA, nekuve nevanoridzidza vadzidzisi vanopa zviyeuchidzo kuvarwere uye nekuisa kunze kune avo varwere vanoomerera (sezvinoratidzwa nevanotarisa zvemagetsi yakavakwa mukati mezvinyorwa zvinoshandiswa) yakashata.
Izvi zvinoratidzawo kuti vanachiremba vanonyanya kutarisirwa vanowanzotaurira steroid inopinza. Nokudaro, pasinei nokuti steroid inobatsira yakawanda sei, inoshandiswa mumamiriro ezvinhu chaiwo-nyika inogumira kuburikidza nekushaya kukwana kutsanangura nekuteerera.
Kunyange zvazvo isiri sarudzo yakasarudzwa yakavakirwa pane zvinyorwa zvemazuva ano, leukotriene modifiers inzira inonzwisisika seyekutanga-mutevedzeri mukuru wevarwere kune avo vanenge vasingatori kana vasingakwanisi kutsungirira steroid inhaled. Kugutsikana kweizvi nzira inotsigirwa neinoti "pragmatic" kuedzwa kwakaitwa muna 306 varwere vakagadzirirwa mune zvekuchengetedza maitiro, umo montelukast yakaratidza kuti yakaenzana nesheedha inhaled semutungamiri wekutanga.
> Sources
> Busse et al. Low-dose fluticasone propionate inofananidzwa ne montelukast kwekutanga-mishonga kurapwa kwechirwere ichi chinoramba chichirongwa: Kuedza kwechipatara kusinganzwisisiki. J Allergy Clin Immunol 2001; 107: 461-8
> National Heart, Lung, uye Blood Institute. Gweta Rinoongorora Gweta 3 (EPR3): Mirayiridzo yeKutsvaga uye Kutungamirirwa kweApmma
> Scaparotta A et al. Montelukast inopesana nehairi inonzi corticosteroids muhutano hwehutano hwakasimba hunoramba huchirwere. Multidiscip Respir Med. 2012; 7 (1): 13.