The Chemical Messenger muhupfungwa Dzako Dzinokonzera Kusagadzikana
Tsanangudzo
Yakagadzirwa mune imwe nzvimbo yeuropi inonzi hypothalamus , orexin imwe yemakemikari vatumwa, kana neurotransmitters, inobata hutano hwehutano uye inosimudzira kudya, kudya uye kushandiswa kwesimba. Masayendisiti akawana orexin muna 1998, uye vave vachitsvakurudza basa ravo mukurara uye kumutsa, pamwe chete nekurapa kwekutambudzika kwekurara.
Orexin, inonziwo hypocretin, inhengo yekirasi yemakemikari inonzi excitatory neuropeptide hormones. Kune mavara maviri akasiyana-siyana akasiyana nemakemikari, imwe inozivikanwa se orexin-A (kana hypocretin-1) uye imwe inonzi orexin-B (kana hypocretin-2). Kushayikirwa kweOrexin kunogona kuvhiringidza kukwanisa kwemuviri wekuramba wakamuka uye kurara, dambudziko rinogona kukonzera kuora mwoyo .
Orexin neNarcolepsy
Muvanhu vane kurara kwakachengetedzwa zvakanaka, orexins inosunungurwa pavanenge vakamuka uye vanobatsira kuwedzera basa mumakwikoni anokurudzira kumuka nekudzivisa kubata REM - kubatwa kwakadzika apo zviratidzo zvinoitika.
Apo mumwe munhu ane chirwere chinoputika, icho chinoratidzirwa nokunyanya kurara kwemasikati uye achidonha akarara asina kunyeverwa, ndechokuti maoironi avo anogadzira orexin vakafa. Pasina orexins, munhu ane chirwere chinonzi narcolepsy haakwanisi kudzora REM kurara. Mune zvimwe zviitiko, kurota izvo zvinowanzoitika munguva yokurara kwe REM kunogona kuitika kana munhu akamuka, zvichiita kuti zvive zvakafanana nekurota.
Asi nei orexin ichifa kunze kwekutanga? Vanotsvakurudza vanodavira kuti kusununguka kunokonzerwa nehutachiona hunokonzerwa nekuzvidzivirira kwega kwega orexin neurons. Kazhinji, vanhu vane narcolepsy vachawedzera huwandu hwezvirwere zvinorwisa streptococcus, iyo ibhakitiriya inokonzera strep throat . Izvi zvinoratidza kuti kurwisa kwemotokari kunokonzerwa ne strep kana imwe hutachiona hwehutachiona, kunyanya nokuti narcolepsy inowanzozara munguva yekupedzisira kwegore kana pakutanga kwezhizha.
Kurapa Matambudziko Okurara ne Orexin
Kana kushayikwa kwearexin kunokonzera kushungurudzika kwekurara, zvino zvinganzwisisika kuti orexins ingakwanisawo kukubatsira kuti uve wakamuka, zvakarurama? Kirasi yemishonga, inonzi orexin receptor vatsoropodzi, ichangobva kugadziridzwa kurarisa zvinetso zvekurara, zvakadai sokushaya hope. Izvi zvinobatsira kurara zvinotora orexin action, zvinodzivisa kuonekwa kwearexin muuropi. Orexin inobatsira mukuchengeta vanhu vakamuka uye vakangwarira, saka kuvadzivisa kunokurudzira kurara.
Orexin receptor agonist dzakasiyana nedzimwe mishonga uye zvepamusoro-the-counter zvigadziro zvekurara mune zvekuti dzinotarisa imwe yakasiyana uye yakawanda yemakemikari system muuropi. Suvorexant, inotengeswa pasi pezita rinonzi Belsomra, ndiyo yekutanga yekirasi iyi yemishonga inowanikwa.
Tarisa izvi zvinyorwa kuti uwane ruzivo rwakanyanya pamusoro pezvinyorwa zvekare uye mamwe matambudziko ekurara:
Kuongororwa Kwekuongorora Kwekurara Kwehope
Tsvaga zviratidzo zvekusuruvara uye zvikonzero
Kukurukurirana Kwekurara Kwekurara
Kurara Mapiritsi Ungabatsira Nokushushikana Asi Ndizvo Zvakakunakira Here?
Zvine Zvirondedzero Zvine zveNhepopi
Sources:
Kurambidza Kurara Mishonga paHarvard Medical School. (2013, January 19). The Science of Narcolepsy. Yakadzorerwa February 06, 2016.
National Sleep Foundation. (nd). Orexin vanopikisana nevarwi: Ikirasi itsva yepiritsi yokurara. Yakadzorerwa February 06, 2016