Vatsvakurudzi vanoratidza dambudziko rinokwanisa kupfuurira kuAIDS mumakore matatu
Kunyange zvazvo pasina nzira yakagadzirirwa nenzira iyo HIV inopfuurira kubva kune mumwe munhu kuenda kune inotevera, kune marwadzo (zvinyorwa) zvinobatanidzwa nekukurumidza kufambira mberi. Izvi zvakasiyana-siyana zvinokonzerwa nekuchinja kwemajini zvinowanzoitika pakutanga mune imwe nzvimbo, kazhinji kupararira kupfuura iyo nzvimbo kuti ive inonyanya-kana isati yakanyanya.
Chimwe chidzidzo chakabudiswa mupepanhau rezvokurapa EBioMedicine rakashuma kuti kumwe kwakasiyana kwakadaro kwave kwakasarudzwa muCuba, iyo inonzi inozivikanwa inova AIDS mukati memakore matatu ekutanga kutapukirwa-zvichiita kuti ndiyo yakanyanya kushungurudzika yakatarwa kusvika panguva ino.
Maererano nemushumo, vatsvakurudzi vanobva kuYunivhesiti yeLeuven muBelgium vakanyatsoona kushungurudzika saRFF19 , kuchinja kwakasiyana kwe HIV kwakaiswa zvitatu zvakasiyana-siyana , A, D, uye G.
Ikoko HIV inowanzoenderera mberi kuAIDS mumakore mashanu kusvika gumi asina kurapwa, CRF19 inoita seichifambira mberi nokukurumidza sekuisa mumwe munhu pangozi yakakura yekurwara uye kufa musati watanga kurapwa .
Zvidzidzo zvidzidzo
Varwere makumi manomwe nevaviri vakaonekwa nevatsvakurudzi sevanokurumidza kufambira mberi (RP), vachiratidzira kana kudonha kwemaCD4 yavo kusvika pasi pemasero 200 / mL kana kuratidza mamiriro ezvinhu eAIDS- kana kuti maviri).
Nguva yepakati yevarwere yaive nemakore 34, asi mavhareji eCD4 panguva panguva yekuongororwa yaiva 276 masero / mL. Kusiyana neizvi, boka rakafananidzwa revatachiona hweHIV pasina ruzivo rweRFF19 rwakanga rwakaenzana neCD4 count ye pakati pe 522 ne 577 panguva yekuongororwa.
Uyezve, kufambira mberi kwakakurumidza kuva neHIV vhutori inotakura imwe-kusvika matatu-yakakwirira kudarika vasiri-vanokurumidza-vanofambira mberi.
Somugumisiro, varwere vane CRF yakasimbiswa vaive nenguva yemunguva pakati peSerononversion neAIDS yemakore 1.4 chete achifananidza nemakore 9.8 nekuda kwevasiri avo vane CRF19.
Tsanangudzo dzekukurumidza kufambira mberi
Vatsvakurudzi vakakwanisa kubvisa zvisungo zvakawanda zvingangodaro zvakatsanangura kukurumidza kufambira mberi kweAIDS. Maererano nehuwandu hwehuwandu hwevanhu, pakanga pane kushamisika kunowedzera kufambidzana kwevanokurumidza kufambidzana kupfuura vasiri-vanokurumidza-vanofambira mberi (49% vs28%). Uyezve, hapana kupesana kwekutapukira kweHIV kuburikidza nekuita zvepabonde (akarara, zvepabonde) zvakaonekwa.
Kubva pane zvavakawana, vatsvakurudzi vanodavira kuti kuchinja kwekukurumidza muRCF19 yakasiyana kunogona kutsanangura chiitiko chacho.
Kazhinji kutaura, kune marudzi maviri e-co-receptors pamusoro pemasero machena eropa anobvumira kupinda kwe HIV muchitokisi: CCR5 neCXCR4 . CCR5 inonzi co-receptor inowanzoshandiswa neHIV muhutachiona hwepakutanga, asi CXCR4 ndiyo inoshandiswa pakuzotevera hutachiona.
NeveCRF19 vari vari, hutachiona hunoshanduka kubva kuCCR5 kusvika kuCXCR4 nekukurumidza zvakanyanya kudarika mamwe matambudziko eHIV . Mukuita kudaro, kufambira mberi kwechirwere kunowedzerwa zvakare, zvichiita kuti kukurumidza kushandiswa kweAIDS.
Zvakawanikwa zvingada kuti kuwedzerwa kweHIV kuongororwa muCubha, iyo iye zvino ine chiyero chekupararira kwe 0.2% (ichienzaniswa ne 0.9% muU.S.) uye zvinopfuura zvuru zvitanhatu zvigaro zvakasimbiswa.
Chinenge chiri pamusoro apa ndechekuti, pamwe nevhareji yenguva kubva kune hutachiwana kusvika kune hutachiona kubva pamwedzi 37 kusvika kumwedzi 55, zviremera zvehutano zvehurumende zvingasakwanise kuziva vanhu vane chirongwa cheRFF19 nokukurumidza zvakakwana kuti zvive nekupararira nokukurumidza kwehutachiona.
Kunyange zvazvo zvirwere zvehutano zvehutano zviripo iye zvino zvave zvasimudzirwa, zvakasiyana-siyana zvakanga zvakasarudzwa muCubva sekare kare muna 2005 uye zvichida zvichibva kuCentral Africa, apo kuparadzirwa kwemhosva kwakange kwataurwa kuAngola, Burkina Faso, Cameroon, neTogo.
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