Lymphoma ndiro zita guru kune marudzi akawanda akanangana emukenza anobva ku lymphocytes. Zvikamu zviviri zvakakura zve lymphoma ndiHodgkin lymphoma (HL) uye isiri Hodgkin lymphoma (NHL) .
Mantle cell lymphoma (MCL) chimwe chezvikamu zvakasiyana zvakasiyana-siyana zveNHL . Kunyanya kunyanya, iyo isiri Hodgkin lymphoma inobva kuB-lymphocytes.
MCL Statistics
- Izvo zvisingashamisi - muUnited States, anenge matanhatu kubva muzana yevanhu vasiri Hodgkin lymphomas vane MCL.
- Inowanzokonzera varume kupfuura vakadzi.
- Iyo inowanzokonzera avo vanopfuura makore makumi mashanu, nevevhareji yemakore yekuongororwa pakati pemakore ekuma 60s.
Zviratidzo
- Zviratidzo zvakafanana nezvimwe zvemarudzi mazhinji eNHL , mune izvo zviratidzo zvakakurumbira ndeimwe kana kuti yakawanda isina kurwadza lymph nodes .
- Zviratidzo zvinowanzoita seusiku kuputika, fever , uye kurasikirwa kwekushaya masimba kunogonawo kuitika.
- MCL inogona kupararira kumudzimai, uye kana izvi zvikaitika, zvinogona kukonzera zviratidzo zvakadai sekurwara uye kurwadziwa mumimba.
Kuongorora nekuongorora
MCL inoratidzika seyakaderera-grade-grade lymphoma pasi pe microscope, maererano neCarcerResearchUK, uye ye-low-grade lymphomas ine masero anotaridzika zvikuru semasero akafanana; zvisinei, MCL inogona kuzviita seyakakwirira-grade lymphoma, ichikura nokukurumidza. Lymphoma masero angave akapararira panguva yekuongororwa - mumakirini emakirini , mapfupa emapfupa uye spleen.
Mishonga uye Zvibereko
Chemotherapy pamwe chete nevamwe vashandi inoshandiswa kurapa MCL.
Mamwe maitiro echemotherapy uye rituximab (Rituxan) anoshandiswa anoshandiswa. Bortezomib (Velcade) inogona kushandiswa kurapa varwere vakadzokazve nechirwere uye vakabvumirwa nevarwere vasingateereri muhutano hwakabatana. Ibrutinib (Imbruvica) inogamuchirwa kune varwere vakadzorerwa MCL zvakare .
Mushonga hauna kujairika kunze kwekuongororwa kare . Chinangwa chekurapa ndechekuchengetedza chirwere ichi kutonga kwenguva yakareba sezvinobvira.
Zvisinei, MCL ndiyo nyaya yezviongorori zvinowanzoitika zvekliniki yekudzidza kuti zvigadziriswe pakurapa.
Nei Inonzi Mantle Cell Lymphoma?
Apo iwe unonzwa shoko rechipfeko, zvichida iwe unofunga nezvenharaunda iyoyo pamusoro pepando umo mapikicha emhuri uye tchotchke dzinowanzochengetwa. Iyo 'mantle' mune mantle cell lymphoma inosvika pane tsanangudzo yakasiyana - imwe inotaura nezvejasi kana shawl; inogona kuvawo chiito, kupfeka kana envelopu - se "mumatambudziko akakomba masango ane masango."
Iyo 'mantle' mune mantle cell lymphoma pakutanga inoreva nzvimbo yemasero yaimbofungidzirwa kuti inonyanya kubatanidzwa muchirwere. Mantle cell lymphomas yakabatanidzwa nenzvimbo yekunze ye lymph node follicles - masero anopoteredza uye akavhara chimwe chinhu chinonzi germinal centre, uye izvi zvose zvinotsanangurwa zvakadzama muchikamu chinotevera.
Izwi rokuti mantle cell lymphoma rakaumbwa muma1991 kutarisa kune imwe nhengo yemarymymasi ine rearrangement yemasikirwo, uye nhasi inofungidzirwa kuti chikamu chenguva chemaitiro esero lymphomas ine ruvara rwakakura, rwakawanda rwekenza. MCL inogona kunge yakasiyana nekuonekwa kwakasiyana-siyana pasi pe microscope, asi kubatanidzwa kwerutivi rwemambo we follicles kunotsanangura kutanga kwezita racho.
Iyo Nyaya uye Mantle
Mifananidzo yakaratidzwa pamusoro peizvi ndechikamu chemuchinjikwa, kana chikamu chimwe chete kuburikidza ne-lymph node yose, sekuonekwa sechishandisa microscope chiedza pachikurusa kwemasimba. Ichi chidimbu chave chakasvibiswa uye chichiiswa pagirazi slide kuitira kuti iwe uone maitiro akasiyana emasero uye kuti akarongeka sei mukati memodhi.
Nzira dzakasvibirira kana mavhesi zvaunoona kudzidza lymph node - kunyanya kumativi ose emutsara-zvinonzi follicles. Nhengo dzemuviri dzinoshandiswa mumakirini, uye dzinogonawo kuumba mumiviri yeclimphoid kune dzimwe nzvimbo dzomuviri. Chimwe chezvizhinji zvepillicles mumufananidzo uri pamusoro zvakanyorwa neB-seli, kana B-lymphocytes, iyo inenge yeropa rega rega.
Zvichienderana nezvinzvimbo idzi B-seli dziri mukati mechirlicle, vangave vane mabasa akasiyana.
Kana iwe ukatarisa zvakanyanya pa follicles, unogona kuona kuti dzimwe dzadzo dzakasviba pakati nepasvibhenu mutsvuku kunze . Chiedza chekati chichizivikanwa sechidziro chekati ye follicle asi iyo yakaoma kunze inonzi inoziva.
B-masero anogona kukura kuti aite zvirwere zvinosungira 'ma tags,' kana antigen, kune vanopinda sevakadai sebhakitiriya. Nepo hutachiona hwemajeni huine B-seli dzinenge dzichikura zvakasimba kuita zvirwere zvinorwisa maantigen kune avo vanoparadza, nzvimbo yakasvibiswa yemazamu inoumbwa neB-masero anozorora uye avo vane 'chiyeuchidzo' chemaantija akasangana nevashamisi vekare .
MCL inoguma apo B-lymphocyte iri kumucheto kwekunze kwe lymph node follicle - nzvimbo ye mantle - inoshandurwa, kana yakaipa. Iko kushandurwa B-lymphocyte inokura nenzira isina kudzora, zvichiita kuti kuwedzerwa kwemasero e-lymphoma, izvo zvinoita kuti kuwedzerwa kwema-lymph nodes.
Sources:
Cancer Research UK. Mantle Cell Lymphoma.
Leukemia uye Lymphoma Society. Mantle Cell Lymphoma Facts .
Non-Hodgkin Lymphomas, rakagadzirirwa naJames O. Armitage, Bertrand Coiffier. Lippincott Williams & Wilkins, Nov 1, 2009.