Sei Kutambudzwa Kunowanzotorwa Kurambana neAlzheimer's Itself
Vanhu vane chirwere cheAlzheimer vanofungidzirwa kuva chero kupi zvako kubva pamasere kusvika kumatanhatu kuwedzerwa mudambudziko rekugumburwa kunoenzaniswa nehuwandu hwevanhu. Pamusoro penzira yechirwere ichi, chero ipi zvayo kubva pamapfumbamwe kusvika ku26 muzana ichaona imwe nzira yekubatwa, zvose zviri pachena uye zvisingaoneki, maererano nekutsvakurudza kubva kuBaylor College School of Medicine muTexas.
Kunyange zvazvo zvisati zvajeka kuti nzira dzipi dzinoita kuti zviitike, pane humwe hutano hunogona kuisa munhu kune ngozi yakawanda.
Nezvezvirwere zveAlzheimer
Chirwere cheAlzheimer ndiyo inonyanyozivikanwa yehutano hwemagariro evanhu , inobata maAmerica anenge mamiriyoni mashanu. Zvinotungamirira kukuderera kunofambira mberi uye kusingagadziriswi kwehupenyu hwemunhu hunoziva, kuratidzira nekurasikirwa kwechirangaridzo uye kuderera zvishoma nezvishoma mukukwanisa kufunga kana kufunga. Iko inowanzoonekwa kune vakwegura uye inotendwa inokanganisa chero ipi zvayo kubva pazana kubva kuzana kusvika 12 muzana yevanhu vanopfuura 65.
Chirwere cheAlzheimer chinokonzerwa nokuwedzera kwepuroteni, inonzi beta-amyloid, muuropi. Sezvo mapuroteni aya ematare akabatana pamwe chete, anogadzira zvipembenene zvinozivikanwa separque inopesana nemakumbo emigwagwa pakati pekufungisisa uye motokari basa.
Zvinokonzera Kukunda Muzvirwere zveAlzheimer
Kunyange zvazvo zvingaita sezvine musoro kufunga kuti kubatwa kweAlzheimer-kukanganisa kunobatanidza zvakananga nekuderera kweuropi, uchapupu hunonyatsoratidza kuti hwakabatana zvikuru kune beta-amyloid pachayo.
Beta-amyloid chaizvoizvo chikamu chemazana makuru anozivikanwa seamyloid precursor protein (APP). Sezvo APP inoputsika, dzimwe makemikari nezvipfeko zvinosunungurwa muuropi izvo zvinogona kuderedza-uye zvakanyanyisa kuderedza-nerve nzira. Sezvo chirwere chacho chichifambira mberi, kuunganidza kwezvinhu izvi zvinogona kukonzera masero emasero kuti apise zvisina kufanira, zvichikonzera kugumburwa.
Mhando mbiri dzakajairika dzekutora zvakaratidzwa kune vanhu vane Alzheimer's:
- Zvimwe zvinokonzera kukanganisika, zvinowanziwo sevanhu vanotadza kukurumidza kuziva kukunda, umo munhu asingazivi zvaanoita uye anotanga kuita zvisingazivikanwi zvakadai sokunyunyutira, kunyora-muromo, kusvetuka, kana kutora zvipfeko
- Secondary generalized tonic-clonic kugumburwa umo kunokonzera kukanganisa (kuchinja kune rumwe rutivi rweuropi) kunosvika pakugadziriswa kwevanhu vose (kunosanganisira zvose zvishoma), zvichiita kuti muviri wose uwedzere
Njodzi Zviitiko
Kunze kwezvinhu zvinokonzerwa nehupenyu hwemagariro ehupenyu, kune zvimwe zvinhu zvinoita kuti munhu awedzere ngozi. Pakati pavo:
- The presenilin 1 (PSEN1) uye presenilin 2 (PSEN2) kuchinja kwemashoko kunowanzoonekwa kune vanhu vane mhirizhonga yakabatana neAlzheimer. Kuchinja kwezvinhu kunopfurikidza nemhuri nekuita basa rinokosha pakugadzira APP.
- Vanhu vane chirwere cheAlzheimer's early (chinosvika vasati vava nemakore makumi matanhatu nemashanu) vanowanzosangana nematambudziko, kunyange zvazvo kugumburwa kunowanzoitika munguva yekupedzisira.
Izvo zvave zvataurwawo kuti kusagadzikana kwemazuva ano, kusanganisira kusagadzikana kwekutadza kuonekwa muhutura , kunogona kuva nemhosva yezvimwe zviito zveAlzheimer zvakadai sokufamba-famba kwemazino (apo munhu anotseuka asina chiyeuchidzo kana kuziva zvaaita).
Kugadzirisa Kutambudza Muvanhu vane Alzheimer's
Haasi munhu wose ane chirwere cheAlzheimer achaona kubatwa. Pakati peavo vanoita, zvinogona kuva zvakaoma kufungidzira sezvo maitiro anokwanisa dzimwe nguva kufananidza zvechirwere chacho pachako. Izvi zvinonyanya kuitika nekunetseka kwakanyanya kwepakati panguva iyo munhu anogona kuerekana "avhara" uye kuratidza unhu husina kunaka.
Kana kubatwa kwaitika kana kunenge kune munhu ane Alzheimer's, test and blood test can often use to help in diagnosis. Mune vanhu vanogara vachigumburwa, electroencephalogram (EEG) inogona kubatsira kubvisa chikonzero chekutora uye chikwata.
Muchiitiko chechirwere chinorwara, chirwere chinowanzosanganisira kushandiswa kwemishonga inopesana nemaperembudzi seTegretol (carbamazepine), Depakote (valproic acid), Neurontin (gabapentin), uye Lamictal (lamotrigine). Mamwe maitiro e-anti-epileptic anofanira kushandiswa nekuchenjerera sezvaanogona kuwedzera zviratidzo zvehutano hwemangwana.
Kana munhu waunoda ane Alzheimer ari kutambura, dzidza zvaunofanira kuita munjodzi uye nzira dzekudzivirira kukuvara kana uchitarisana nechiitiko chakaoma, tonic-clonic.
> Sources:
> Akaberekwa, H. "Kukunda muhosha yeAlzheimer." Neuroscience . 2015; 286: 251-63. DOI: 10.1016 / j.neuroscience.2014.11.051.
> Nicastro, N .; Assal, F .; uye Seeck, M. "Kubva pano kuenda kuhuputi: njodzi yekubatwa nevarwere vane chirwere cheAlzheimer." Kushungurudzika Kwepfungwa . 2016; 18 (1): 1-12. DOI: 10.1684 / epd.2016.0808.
> Sherzai, D .; Losey, T .; Vega, S. et al. "Kukunda uye kuora mwoyo kwevanhu vakwegura: Nationalwide Inpatient Sample 1999-2008." & Epilepsy Behavior . 2014: 36: 53-6. DOI: 10.1016 / j.yebeh.2014.04.015.