Kusiyana nechirwere ichi, chiremera chinonzi gluten chinoratidzika sechichitsvaga zvakakwana genetics
Kunyange zvazvo kutsvakurudza kune chisina kuchena kwechiriacuten senzwiva chiri kungotangira uye zvidzidzo zvichiratidza kuti mamiriro akasiyana haasati ataurwa, zvigadzirwa zvekutanga zvinoratidza kuti haufaniri kutakura chimwe cheiyo inonzi chirwere checalyac genes kuitira kuti uwedzere gluten senitivity.
Vaya vane chirwere chechiliac , iyo yakanakisisa inonzwisiswa yemarudzi mashanu akasiyana-siyana e gluten "kurwisa," nguva dzose inotakura chimwe chezviviri zviviri zvemajini.
Muzvinyorwa, vanachiremba vanowanzoshandisa maitiro ekuongorora maitiro ekutonga kunze kwechirwere chechiliac - kana iwe usina geni raidiwa kukura celiac, vanoti, iwe hauna chokwadi hauna mamiriro acho.
Mazita eusina-celiac senzwi rekukutu haana kunyatsojeka.
Maitiro eGenetics Anotsvaga Basa muCeliac Disease
Iyo "chirwere chechiliac" inowanikwa munenge 35 kusvika ku40 muzana yehuwandu hwehuwandu hwevanhu, uye kuti iwe une majeni hazvireve kuti iwe uchazove uine hutachiona hwechiliac - zvinongoreva kuti iwe une simba rekuberekwa kuti uite saizvozvo.
Majini anowanzoita kuti uve nechirwere chechiliac anozivikanwa sejeni reHLA-DQ, uye anowanikwa pane hutano hweHLA-class II yeDNA yedu. Munhu wose anowana imwe kopi yeHLA-DQ gene kubva kuna amai vavo uye yechipiri kopi yeHLA-DQ gene kubva kuna baba vavo.
Iko kune mazana mana emhando dzemagenhi eHLA-DQ, anozivikanwa seHLA-DQ1, HLA-DQ2 , HLA-DQ3 uye HLA-DQ4. HLA-DQ1 inowedzera kuputsika muHLA-DQ5 uye HLA-DQ6, nepo HLA-DQ3 ichiwedzera kuputsika muHLA-DQ7 , HLA-DQ8 uye HLA-DQ9.
Sezvo munhu wese akawana majini maviri eHLA-DQ (imwe kubva kuna amai vavo uye mumwe kubva kuna baba vavo), munhu anogona kuva nemumwe wezvizhinji, zvakasiyana zvakasiyana-siyana zvegene. Zvimwe zvemajeni aya zvinokutadzisa kune chirwere chechiliac, asi kutsvakurudza kwepakutanga kunoratidza mamwe majeni angakonzera kuti uve nekunzwisisa.
Isu tinoziva kuti vazhinji vevanhu vane chirwere chinopupurirwa chinonzi biopsy-chinoratidzwa chinonzi HLA-DQ2 kana HLA-DQ8 (a subset of HLA-DQ3). Zvisinei, kubva pa35% kana 40% yevanhu vanoita chimwe kana kuti zvose zvezvipembenene zvechiliac, mazita ejeni haareve kuti iwe zvechokwadi uchawana celiac - kune zvimwe (zvisingawanikwe) zvinhu zvinobatanidzwa.
Genesisi Inobatanidza mu Gluten Sensitivity
Kana zvinouya nekunzwisisa kwe-gluten, zvinoratidzika kuti chirwere cheeceliac maitiro haana kunyanya kutamba, maererano nezvimwe zvitsva zvitsvakurudzo.
Mumusana pekutsvaga kwekutsvakurudza kwakabudiswa kutanga kwegore ra2011 neYunivhesiti yeMadganist muchechi mutsvakurudzi uyu Alessio Fasano, vanyori vakaongorora maitiro eavo vakaonekwa vane gluten senzwi, uye vakazvienzanisa nedzimwe boka revanhu avo vose vainzi "goridhe" chiyero " chirwere chechiliac chinorwara kuburikidza neropa rekuongorora uye biopsy.
Vatsvakurudzi vakaona kuti 56% chete yeavo vakaonekwa seGluten senheyo yakabata DQ2 kana DQ8, zvichiratidza kuti mazamu aya haana kunyanya kubatanidzwa mukuvandudzika kwekunzwisisa kwejuten kupfuura ivo vari mukuvandudza chirwere chechiliac. Zvisinei, mazamu akaonekwa kakawanda kune avo vane gluten senzwi kupfuura zvavanoita munharaunda yevanhu vakawanda, saka zvichida vanogona kutora chikamu mukunzwisisa kwe-gluten - hazvisi pachena kuti chii chavanogona kuita.
Zvechokwadi, vanachiremba vakawanda vanoda kuona Dhiyabhorosi Fasano zvaakawana zvinotsanangurwa vasati vabvumirana kuti kunzwisiswa kwe gluten kune. Dhiyabhorosi Fasano iye zvino ari kushanda kuti aone zvinokonzerwa nezvinokonzera zvinogona kutungamirira kuongororwa kwekunzwisisa kwejuten .
Zvimwe zveGenesheni Zvingangobatanidzwa MuG Gluten Kusagadzikana
Dhiyabhorosi Kenneth Fine, uyo akakurudzira muitiro wekuedza kuongorora weEngoLab gluten , anoti anotenda kuti munhu wose ane majeni HLA-DQ2 neHLA-DQ8 "achaunza gluten kumagadzirirwo emusikirwo emagadzirirwo ekuita-kureva, kuva gluten."
Asi avo vane HLA-DQ2 neHLA-DQ8 havasi voga mukunzwa kwavo kwema gluten, Dr. Fine anoti.
Anotenda kuti munhu wose ane HLA-DQ1 uye HLA-DQ3 zvakare anotarisirwa kuva neutsi hwekudya. Izvo zvinoreva kuti vanhu chete vane makopi maviri eHLA-DQ4 (pasi pe1% yevanhu veUnited States) havana zvirwere kubva ku genetically induced gluten senitivity, maererano naDkt Fine. Mune maonero ake, vamwe vose vane maitiro ekugadzira maitiro.
Vanhu vane makopi maviri emagetsi, zvakadai seHLA-DQ7 (imwe maitiro eHLA-DQ3 akafanana neHLA-DQ8), zvinokonzera kukanganisa kwakasimba kune gluten, sezvo vanhu vane makopi maviri eHLA-DQ2 vanogona kukura chirwere, anodaro.
Yeuka, tsvakurudzo yaDkt Fine haisati ichitsanangurwa nevamwe vanoongorora genetics yekunakidzwa kwechiliac uye gluten, saka hazvisi pachena kana zvichabvumidzwa kana kwete. Zvisinei, kana huchapupu hwake huchava hwakarurama, izvi zvinoreva kuti anenge munhu wese muUnited States ane mamwe maitiro ezvakakosha anodiwa kukudziridza kunzwisiswa kweGluten. Zvisinei, sezvo kwete munhu wose ane chiitiko (ona nyaya yangu yekuti vanhu vazhinji vane Gluten Sensitivity here? ), Panofanira kunge kune zvimwe zvikonzero uye mazita ejeni anobatanidzwa.
The Bottom Line
Vamwe vatsvakurudzi vachiri kudikanwa kusimbisa izvi zvingangova nemigumisiro uye zvikonzero zvekuti zvive zvakagamuchirwa kune vose munharaunda yezvokurapa, uye kune zvakawanda zvekusava nechokwadi pakati pechiremba kana kunzwa kwekukutuka kuripo zvachose. Kubva pane izvi zvose, kuongororwa kwegene kwekunzwa kwejuten hakusviki kuva yakakosha kana inoshanda munyika chaiyo panguva ino, kana iripo.
Kunyange zvakadaro, zvose Dr. Fasano naDkt Fine, pakati pevamwe, vanoramba vachidzidza nyaya ye gluten senitivity genetics. Tsvakurudzo yavo inoratidza kuti kunyange kana thyliac gene test yaive isina kunaka, iwe unogona kuva nechinetso ne gluten .
Sources
EnteroLab chokwadi sheet: Mibvunzo Inowanzobvunzwa Pamusoro Pezviongorudzo.
A. Fasano et al. Kuwedzera kwegomba kuputika uye mucosal immune gene kutaura mumamiriro maviri maviri anokonzerwa ne-gluten: chirwere chechiliac uye senzwi. BMC Medicine 2011, 9:23.