Chirwere cheCeliac chimiro chechimiro, izvo zvinoreva kuti unoda kuva ne "maitiro" ezvakakuita kuti uzvikure uye uonekwe nawo. HLA-DQ2 ndeimwe yemishonga miviri yakakosha yemagetsi, uye inoitika kuti ndiyo inowanikwa yakawanda inowanikwa muhosha yeecliac (HLA-DQ8 ndiyo imwe inonzi "celiac gene").
Vanachiremba vakawanda vanofunga kuti unoda kana imwe kopi yeHLA-DQ2 kana HLA-DQ8 kuti ikure chirwere ichi.
Celiac Genetics Basics
Genetics inogona kuva nharo inokanganisa, uye genetics yehosha yeecliac inonyanya kuvhiringidza. Heino imwe tsanangudzo yakajeka.
Munhu wose ane geni reHLA-DQ. Ichokwadi, munhu wose anowana mairi maviri emagetsi eHLA-DQ - mumwe kubva kuna amai vavo uye mumwe kubva kuna baba vavo. Kune marudzi akawanda akasiyana-siyana eHLA-DQ mazai, kusanganisira HLA-DQ2, HLA-DQ8 , HLA-DQ7 , HLA-DQ9 uye HLA-DQ1 .
Ndiyo HLA-DQ2 uye HLA-DQ8 mazamu akasiyana-siyana anomutsa dambudziko rako rekushaya chirwere ichi.
Sezvo munhu wose achiwana maitiro maviri eHLA-DQ (mumwe kubva kumubereki mumwe nomumwe), Zvinogoneka kuti munhu ave nekopi imwe yeHLA-DQ2 (inowanzonyorwa seHLA-DQ2 heterozygous), mairi maviri eHLA-DQ2 (HLA-DQ2 homozygous) , kana kwete ma kopi eHLA-DQ2 (HLA-DQ2 asina kunaka).
Mukuwedzera, pane zvimwe zvitatu zvakasiyana zveHLA-DQ2 geni. Rimwe, rinozivikanwa seHLA-DQ2.5, rinopa dambudziko guru kune chirwere ichi; vanenge 13% vevaCaucasian vagari vemuUnited States vakatakura geni iri.
Zvisinei, vanhu vane dzimwe shanduro dzeHLA-DQ2 zvakare vari pangozi yezvirwere zvechiliac.
Kana Ndiine Gene, Ndeipi Ngozi Yangu?
Izvozvo zvinoenderana.
Vanhu vane makopi maviri eHLA-DQ2 (inonyanya kuwandisa yehuwandu hwevanhu) vanotakura dambudziko guru pane chirwere ichi. Maererano nehuwandu hwehutano hwehutano hunobva pakutsvakurudza kwakabudiswa kwakave kwakagadzirwa nejenetic test service MyCeliacID, chirwere checliac chinowanikwa kune vanhu vane makopi maviri eDQ2 pachiyero chakapoteredza makumi matatu nemakumi matatu evanhu vakawanda.
Vanhu vane mabhuku maviri eHLA-DQ2 vanewo mungozi yakakura yekuda kwechimwe chirwere chinokonzera cecacac chirwere (icho chinoitika apo kudya kweguten kusingaratidzi kushanda kudzora mamiriro acho ezvinhu), uye neT -cell lymphoma , rudzi rwekenza inobatanidzwa nechirwere chechiliac.
Vanhu vane kopi imwe chete yeHLA-DQ2 vane kanenge ka10 kengozi ye "inowanikwa vanhu vose" yehosha yeecliac, maererano naMyCeliacID. Vaya vanotakura zvose HLA-DQ2 neHLA-DQ8, iyo imwe yecliac chirwere chegene, ine nguva dzinenge 14 iyo "inowanikwa nevanhu vose" ngozi.
Zvimwe Zviitiko Zvinobatanidzwa
Haasi munhu wose anotakura HLA-DQ2 inoita chirwere chechiliac - geni iripo mune zvinopfuura 30% zvevanhu veUnited States (kunyanya avo vari nechokuchamhembe kweEuropean genetic heritage), asi inenge 1% yeAmerica chaizvoizvo ine chirwere ichi.
Vanotsvakurudza vanotenda kuti kune mamwe mazita emagetsi akabatanidzwa mukugadzirisa kana mumwe munhu anokonzerwa nemararamiro anokonzera mamiriro acho ezvinhu, asi haasati aziva mazita ose ejeni anobatanidzwa.
Sources:
Al-Toma A. et al. Human Leukocyte Antigen-DQ2 Homozygosity uye Kuvandudzika kweChirangaridzo Celiac Disease uye Enteropathy- Yakabatana neT-Cell Lymphoma. Clinical Gastroenterology uye Hepatology. 2006 Mar; 4 (3): 315-9.
MyCeliacID Risk Stratification Table. Yakasvika March 20, 2012.
Ploski R. et al. Pamusoro peHLA-DQ (alpha 1 * 0501, beta 1 * 0201) -kusagadzikana kwakasanganiswa mune chirwere chechiliac: inogona kuisa mazamu emagetsi eDQB1 * 0201. Tissue Antigens. 1993 Apr; 41 (4): 173-7.
Vader W. et al. HLA-DQ2 chirwere chemajeni chinokonzerwa nechirwere chechiliac chakananga zvakananga nehukuru uye hupamhi hwe-gluten-yakananga T chengeri mhinduro. Proceedings of the National Academy of Sciences. 2003 Gunyana 14; 100 (21): 12390-12395.