Kukanganisa Kunyorera Kubva Pakudzidza Kwakashata
Vanhu vasingabereki utachiona hwakakwana-uye naizvozvo hypothyroid -benefit kubva ku levothyroxine , kana kuti yakagadzirwa nehomoni yehomoni. Utachiona hweHyroid hunokosha pakugadzirisa metabolism yakakodzera. Nokuda kwechikamu chikuru, kutungamirirwa kwehomori yekemikari kunobereka zvishoma zvigumisiro zvinokuvadza, uye kudarika kudarika. Zvimwe zvinowanzosvibisa zvakaipa zvinosanganisira marpitati, kuwedzera kwemwoyo, kuputika, kutuka, uye kutya.
Zvisinei, kutsvakurudza kutsva kunobatanidza kushandiswa nguva dzose kweLevothyroxine (Synthroid) nekenza yekenza . Kunyangwe ichifadza, chidzidzo chechidiki ichi hachisi chakanaka uye chinoda kupfuurira mberi.
Kutsvakurudza
Mune imwe nyaya yaJuly 2017 yakabudiswa mu Journal of Clinical Pharmacology , Hung uye vanyori vanyori vakaongorora sangano pakati peevothyroxine nekenza yekemekari vachishandisa kuongorora kwevanhu. Kutora kubva kune data inomiririra 1 mamiriyoni eTaiwanese, Hung uye avo vaishanda navo vakawana vanhu 1285 vakagamuchira nguva yokutanga kuongororwa kwekenza yekemikari pakati peJanuary 1, 2001, uyeDecember 31, 2013.
Vakuru ava vane kenza yekotori vakazobatana nevakuru 3855 vasina kenza yekemikari (kureva, boka rinodzora) avo vakanga vakafanana mumakore, zvepabonde, uye chiremba vanoshanyira. Pakazara, pakanga pane vanhu 5140. Pakati pevanhu vakuru 5140, vatsvakurudzi vakaona vanhu makumi manomwe vakawanikwa vaine hypothyroidism nedzidziso yezvemagokorokori asi havana kumbove nekuita chirwere chetroji.
Zvigumisiro zvakagadziriswa nekuremekedzwa kune mari yegore negore, nzvimbo yekugara, kuguta kweguta, kushandiswa kwefodya, uye zvirwere zvakasiyana-siyana. Pakati pacho, vanhu makumi manomwe vane hypothyroidism vakasiyana nenzira imwe huru: kenza yeukamera yekuongorora.
Hung uye avo vaishanda navo vakawana vanhu vakuru 37 vane hypothyroidism avo vakagadzira kukura kwekenza yekroid.
Vakatsanangurawo vanhu 33 vane hypothyroidism vasina kuve nekenza yekemikari. Vatsvakurudzi vakazofananidza mapoka aya maviri achiremekedza zvinhu zvakawanda, kusanganisira kushandisa nguva dzose levothyroxine.
Vatsvakurudzi vakawana kuti vanhu vakuru vane kansa yekemekari vainyanya kuonekwa kuti vane hypertension, chirwere cheshuga, osteoporosis, uye hyperlipidemia.
Chinonyanya kukosha, Hung nevakashanda navo vakawana kuti vanhu vakuru vane hypothyroidism avo vaigara vachitora levothyroxine vaiwanzoita kenza yekerosi. Izvo zvisina kufanira levothyroxine inoshandisa, zvisinei, yakanga isina kubatana nekenza yekameti.
Thyroid Hormone uye Kanzera
Utachiona hweHyroid hunodiwa pakukura kwemazuva ose, kubudirira, uye metabolism. Nokuti kenza inoreva kusadzora kushandiswa kwemasero emasero, yakanyatsofungidzirwa kuti utachiona hwehomoni hunoita nenzira imwechete "kubvumira" kenza. Mune vanhu, zvishomanana zvidzidzo uye kutsvakurudza zvishoma zvinotsigira pfungwa yokuti utachiona hweHroid hunoita kuti uwane kenza.
Zvinoshamisa, mubhuku ra2009 rakanzi "Thyroid Function uye Cancer Risk: A Prospective Population Study," Hellevik uye vanyori vanyori vakawana hukama pakati pepamusoro yehomoni yekemikari uye mamwe marudzi ekenza. Vakatevera 29,691 vaNorwegi kwemakore 9. Pakutanga kwekucherechedza nguva, hapana mumwe wevanhu ava akawanikwa ane chirwere chetachiona.
Vatsvakurudzi vakawana kuti vanhu vakange vakaderera thyrotropin mavambo pakutanga kwekudzidza, iyo inofadza ye hyperthyroidism, vakange vari pangozi yakakura yekupedzisira kuwedzera mapapu nekenza yeprotate. (Kwakanga kusina kusangana pakati pe hyperthyroidism nekenza yekoloni kana kenza yemazamu.)
Uyezve, Hellevik nevamwe vaishanda navo vakawana kuti hypothyroidism haina kubatana nekenza ngozi.
Kusiyana neizvi, kumwe kutsvakurudza kunoratidza kuti vanhu vanokura hypothyroidism mushure mekunge vaongororwa nemukati mutsva nemutsipa vanogara kwenguva refu. Uyezve, vanhu vane kenza yemazamu avo vane chirwere chetachiona-uye saizvozvo hypothyroidism-vanogona kurarama kwenguva refu, zvakare.
Mune mamwe mazwi, kumwe kutsvakurudza kunobatsira pane zvingaita kuti kutapudzwa kwetachiona kunogona kunge kwakadzivirira pamigumisiro yekenza. Mune zvidzidzo zvezvipfuwo, levothyroxine yakaratidzwa kuti ikurudzire ronda rekukura nekupararira. Uyezve, hypothyroidism inononoka kuderedza tumor kukura, inogadzirisa tumarara kupararira, uye inovandudza kupona.
Mechanism
Plandish gland inoburitsa hormone inonzi hormone ye -thyroid-stimulating (TSH) . Kutungamirirwa kwehomori yehutori yakadai sev levothyroxine inoderedza TSH mazinga nemashoko asina kunaka. Pasina TSH, utachiona hunorasikirwa nechinangwa uye huchienda. Nokuda kwechikonzero ichi, utachiona hweHerosi hunoshandiswa sekunyangarika kwemakumbo ematokisi uye goiters.
Intuitively, utachiona hunoputika hunofanira kuva hushoma kuva kenza. Zvisinei, ne levothyroxine hutungamiri, inofungidzirwa kuti huwandu hwemasero ehutori hwetachiona hunogona kukunda izvi zvinopesana uye zvinoita kuti uwane kenza.
Kunyange zvazvo magetsi asina kunyatsojeka, levothyroxine inogona kugoverana kana kuenzanisa kuora kwemaitiro. Mune mamwe mazwi, levothyroxine inogona kutamba zvakananga kana kuti zvisina kurongeka mumakumbo ekugadzirwa. Maererano neHung uye vanyori vanyori:
Kusvika iye zvino, zvinoratidzika kunge pasina huongorori hunobudisa nzira dzinogona kuitika ye thyroxin-related carcinogenesis. Kunyange zvakadaro, chiitiko chacho chinogona kutsanangurwa nenzira 2 dzinokwanisa. Chokutanga, thyroxin inogona kuita senhengo inokurudzira mumagariro echecogogenesis .... Chechipiri, thyroxin pachayo inogona kukurudzira kukura kwemasero emukenza wekemikari.
Izvi Zvinorevei?
Kutorwa woga, kutsvakurudza uku kuwana kuti nguva dzose levothyroxine inoshandiswa yakabatanidzwa kune imwe nguva kanorapa yekenza inoreva zvishomanana. Izvi zvinoguma zvakabva pane imwe nzvimbo yekutsvakurudza yakasarudzwa yakanga iri duku. Uyezve, panogona kunge kune nyaya nekutsvakurudza.
Chokutanga, vashomanana vanotora levothyroxine ye hypothyroidism vanoenderera mberi kukura chirwere chetachiona kana mamwe mhando dzekenza. Kunyanya, Hung nevakashanda navo vakawana kuti 2.88 muzana chete yezvidzidzo ne hypothyroidism yakaramba ichisimudza kenza yekameti. Uyezve, chete 0,86 muzana yezvidzidzo pasina hypothyroidism yakaramba ichiwedzera kanhi yekemikari.
Chechipiri, chidzidzo ichi ndicho chekutanga chekuratidzira kusangana pakati pemazuva ose levothyroxine kushandiswa uye kenza yekameti. Ramba uchifunga kuti sangano rakasiyana nechikonzero. Vatsvakurudzi havana kuratidza kuti levothyroxine inokonzera kenza yekenza.
Maererano neHung uye vanyori vanyori:
[A] kunyange zvazvo zvitsva zvinoratidza kusangana pakati pekenza yekenza uye kushandisa thyroxin nguva dzose, zvidzidzo zvakawedzerwa zvinodiwa kuti uwedzere kuongorora nekugadzirisa izvi zvakawanikwa .... Kunyangwe basa rechokwadi re thyroxin mukukura kwekenza yekemikari rinoramba richiongororwa, vanachiremba vanogona kufunga nezvekushamwaridzana uku kana kurapa varwere vane subclinical hypothyroidism.
Vanyori vanobvuma pachena kuti zvavanowana ndezveshamwari dzinoda kubviswa kunze kwekutsvakurudza mberi. Ichi chidzidzo chiduku uye tinoda mazamu makuru ekuenzanisa kuti zvive nyama chaiyo chero sangano.
Zvinofadza kuti vanyori vanoita imwe nzira yekukurudzira kuti vanachiremba vanogona kuchengetedza kushamwaridzana uku mupfungwa pavanorayira levothyroxine varwere vane subclinical hypothyroidism, kana kushaya utachiona husina kunaka. Izvi zvinokurudzira zvichida nguva isati yasvika.
Chechitatu, chinangwa chekutsvakurudza chingakanganisa. Kunyanya, vatsvakurudzi havasi kusiyanisa pakati pezvikonzero zvakasiyana zve hypothyroidism. Mucheche hypothyroidism, iyo inogona kuwedzera kushandiswa kusinganzwisisiki kweevothyroxine, yakasiyana nekuwedzerwa kwakaoma hypothyroidism, iyo inogona kushandiswa nguva dzose kushandisa levothyroxine, uye kusiyana uku kwemukati kunogona kureva kuwedzera kwemitengo yekenza inowanikwa pakati pevashandisi vese ve thyroxine. Chaizvoizvo, vanotsvakurudza ndivo maapulo nemaarangi.
Chechina, vatsvakurudzi vakashandisa dhamusi yedhipatimendi kuti vatsanangure kushandiswa kwetachiona nguva dzose uye kusinganzwisisiki, iyo nzira isina mubvunzo.
Shoko Rinobva
Kana isina kusiya, hypothyroidism inogona kunge isinganzwisisiki uye inotambudza. Vanhu vane hypothyroidism vanonzwa vakaneta, kuvhiringidzika, kuora mwoyo, ganda rakaoma, kuwedzera kuwedzera, nezvimwewo. Levothyroxine inobatsira kurapa kwe hypothyroidism uye inogona kuvandudza hupenyu hwehupenyu. Vanhu vakawanda vanotora levothyroxine zuva roga roga pasina zvinetso.
Kana chiremba wako akakuudza iwe nguva dzose levothyroxine mukurapa hypothyroidism, haufaniri kunge uine hanya nemishonga iyi inokonzera kenza. Nokuda kwehuwandu hwevanhu, kubatsirwa kweLevothyroxine kwakanyanya kukunda chero zvipi zvingava nemigumisiro yakaipa, kusanganisira kanakwanisika kenza. Uyezve, ichi chidzidzo chinobatanidza levothyroxine nguva dzose kushandiswa uye kenza yekameti yakakosha uye inogona kunge yakakonzera nekugadzira. Pakupedzisira, chibvumirano icho vanotsvakurudza vanonyatsotsanangura chinoda kunyanya kutsvakurudza zvisati zvaitika chero zvipi zvaro zvingashandurwa zvinogona kuitwa.
Iwe haufaniri kushandura mishonga yako yemishonga nokuda kwekutya kenza yekorosi inobva pane iyi imwe duku, zvichida kudzidza kusina kukodzera. Kana iwe uchigara uchitora levothyroxine pasi pekuongororwa kwechiremba wako, ndapota famba uchitevera nepurogiramu iyi yekurapa. Chero kuchinja kupi mune chirongwa chako chekurapa kunofanira kukurukurwa nachiremba wako.
Kana iwe uine hanya nezvehukama pakati peLevothyroxine nekenza yekenza-kana chimwe chinhu, nokuda kwechinhu ichocho-tapota taurai izvi nejairo renyu rekupedzisira kana kuti chiremba wokurapa . Nokubvunza mibvunzo, hausi kungozvigadzirira zvaunofunga asiwo kudzidza zvakawanda pamusoro pemamiriro ako. Insight chikamu chinokosha chekubudirira kurapwa.
> Sources
> Cantrell F. Chitsauko 150. Utachiona Hormone. Mu: Olson KR. eds. Kutyisa uye Kuderedza Zvinodhaka, 6e New York, NY: McGraw-Hill; 2012.
> Hellevik, AI, et al. Thyroid Function uye Cancer Risk: A Tarisiro Yevanhu Vechidzidzo. Cancer Epidemiology, Biomarkers & Prevention. 2009; 18: 570-574.
> Hung, SH, Chung, SD, Lin, HC. Kushandisa Thyroxin Kunosanganiswa Nengozi Yakawanda yeChroid Cancer Muvarwere Ne Hypothyroidism. Journal of Clinical Pharmacology. July 19, 2017. (e-pub mberi kwekudhinda)
> Stoll, SJ, et al. Utachiona hweHormone Replacement shure kweTyroid Lobectomy. Surgery. 2009; 146: 554-560.