Genetics inobatanidza nengozi yehutachiona hwemotokari
Chirwere cheCeliac chirwere chinokonzerwa nemaronda umo kudya kwe gluten kunogona kukonzera zviratidzo zvepachiviri uye kukuvara kumatumbo maduku. Iyo chirwere chisina kunyatsonzwisiswa asi chinoratidzika chakabatanidzwa zvakasimba muchikamu kune munhu genetics.
Tinozviziva izvi kubva pamwero wakazara maererano nehuwandu hwehutachiona hwechiliac hunowedzera zvakanyanya kana chiyero chekutanga chechiremba, chakadai semubereki kana hama, ane chirwere ichi.
Mumakore achangobva kupfuura, nekuuya kwekuongorora mazita , masayendisiti ave akakwanisa kuziva mbiri mbiri dzemajini dzinowanzoonekwa kakawanda kune vanhu vane chirwere ichi. Izvo ndezveboka rejen complexes rinonzi human leukocyte antigen (HLA) uye rinosanganisira:
- HLA-DQ2, iyo iripo inenge inenge 90 muzana yevanhu vane chirwere ichi
- HLA-DQ8, iyo inowanikwa mune zvikamu zvinenge masere zvevanhu vanofanana
Kunyange zvazvo HLA-DQ8 ingaita sechikonzero chinonyanya kukonzera chechirwere, inokonzera huwandu hwemhosva dzisiri dzeDQ2 uye dzine dzimwe humwe hunoita kuti hurumidze kuuraya.
Link Between HLA-DQ8 uye Celiac Disease
Kune marudzi akawanda akasiyana-siyana (serotypes) emagetsi eHLA-DQ ayo DQ2 neDQ8 ari maviri chete. Seboka, basa ravo guru nderokubatsira muviri kuti uone majekiseni angangokuvadza, achibvumira masimba ezvirwere kuti atarise masero aya kuti asapindire.
Mumwe nomumwe wedu ane mapepa maviri eHLA-DQ serotype, iyo yatinowana nhaka kubva kuna amai vedu uye imwe yatinogara nhaka nababa vedu.
Kana munhu akawana nhaka imwecheteyo yeHLA-DQ kubva kuvabereki vavo, iye anonzi ari homozygous. Kana munhu wacho akawana miviri yakasiyana, iyo inonzi inonzi heterozygous.
Sezvo serotype yakasiyana, HLA-DQ8 inowanzobatanidzwa kune zvirwere zvinotapira muviri zvinosanganisira chirwere chechiliac, rheumatoid arthritis , uye vana vechirwere cheshuga .
Pamusana pezvikonzero zvisingazivikanwi, iri geni rinogona kuita kuti muviri uzvidzivirire pachako, uchitungamirire maitiro ezvirwere zvekuzvidzivirira kuti varwise uye kuparadza masero ayo.
Nezvechirwere chechiliac, tsvakurudzo yakaratidza kuti kuva HLA-DQ8 kubvongodzana kunowedzera dambudziko rako gumi richifananidzwa nehuwandu hwevanhu. Kunyange nekopi imwe HLA-DQ8, njodzi yako inopfuura kaviri.
Zvisinei, heterozygosity haisi nguva dzose inoreva ngozi shoma. Kana ukabatanidza HLA-DQ8 nehuwandu hwehuwandu hweHLA-DQ2, hutano hwako hwechirwere huchikwira kusvika ka14 nguva dzevanhu vose.
Izvo DQ8 Inofananidzwa neNharaunda
Izwi rokuti HLA-DQ8 rinogona kusiyanisa zvikuru kubva kune rumwe rutivi rwepasi kune rinotevera. MuEurope, somuenzaniso, ndiyo inowanzobatanidzwa nechirwere chechiliac uye vana vechirwere cheshuga. Saizvozvowo, kuJapan, uko iyi haisi HLA-DQ2, serotype yeDQ8 ndiyo chete inokonzera chirwere chechiliac (yakasungwa, muchidimbu, nekuderera kwe gluten mukudya kweJapan).
Nokuenzanisa, HLA-DQ8 inomiririra chikamu chiduku chezvirwere zvechiliac muAmerica uye inowanzobatanidzwa ne rheumatoid arthritis. Kwete kuti inokosha mumagariro ekufambira mberi kwezvirwere. Kusvika parizvino, hapana chirevo chokuti serotype inobatsira pamusana pekukura kwechirwere.
Sezvo zvakadaro, zvinenge zvichiitika kuti zvimwe zviitiko zvinotora chikamu mune chikonzero nei vamwe vanhu vachiwana chirwere chakaipisisa kupfuura vamwe.
> Kwakabva:
> Tjon, J .; Van Bergen, J .; uye Koning, F. "Chirwere cheCeliac: chakaoma sei kuwana?" Immunogenetics . 2010; 62 (10): 641-651. DOI: 10.1007 / s00251-010-0465-9.