Genetics & Clustering mumhuri
Mubvunzo:
Inonzi Fibromyalgia Hereditary?
"Vanhu vanoverengeka mumhuri mangu vave vane fibromyalgia uye iye zvino ndiri kuratidza zviratidzo zvakawanda izvo zvinoita kuti ndinetseke chaizvo nezvevana vangu-ndavaparadza here?" "Fibromyalgia" here?
Mhinduro:
Izvi zvinowanzova nehanya nazvo. Zvinotyisa kufunga kuti tingave tisina, tisingazivi, takapfuura chirwere chisingaperi, chinokanganisa pamwe chete nevana vedu.
Mashoko akanaka ndeokuti kunyange zvazvo vangave vane njodzi yakakwirira, hazvinyatsovimbiswi kutanga fibromyalgia.
Kubva pakutsvakurudza, rutendo rwemazuva ano nderokuti fibromyalgia haisi iyo inowanikwa mumutauro wepakati, apo kushanduka kwegene rimwe chete kunogadzirisa unhu hwakapiwa. Izvozvo zvinonzi monogenic, uye inodzora zvinhu zvakadai semuvara weziso rebhuruu; zvisinei, humwe uchapupu hunoratidza kuti mazamu ako anogona kukugadzirira iwe ku fibromyalgia, asi nenzira yakaoma inosanganisira majini mazhinji, ayo anonzi polygenic.
Chii chakasiyana?
Mune chikwata chechiGiriki, chimiro chechimiro, chizvarwa, mahedheni chaiwo aunowana kubva kuvabereki vako ndiyo inonyanya kugadzirisa kana iwe uchawana chirwere. Semuenzaniso, mu cystic fibrosis, mwana wevabereki ivo vose vane hutachiona vane chirwere ane 25 muzana yekana yekuvandudza cystic fibrosis. Vanogona kuwana kodzero yekuchinja muviri kana kuti havaiti. Kana vakawana kuchinja, vanowana chirwere chacho.
Nekugadziriswa kwema polygen, hazvisi nyore sezvo mazamu ako anongoreva kuti chirwere chinogona kuitika pasi pemamiriro ezvinhu akanaka . Izvozvo zvinoreva kuti pane ngozi yakawanda kudarika kune vamwe vanhu, asi kwete chokwadi. Kazhinji, zvimwe zvinhu zvinofanira kuitika kuti zvigadzire chirwere chacho.
Mu fibromyalgia, zvimwe zvinhu izvi zvinogona kusanganisira:
- zvimwe zvinhu zvinotambudza kusingaperi
- autoimmune chirwere
- kushushikana kwehope
- kusingaperi kunetseka
- chirwere chinotapukira
- uropi hunokanganisa chimiro
Dzimwe nyanzvi dzinofungidzira kuti zvinhu zvakasikwa nezvakatipoteredza zvakadai sekushushikana kwezvokudya kana kuwanika kune zvinodhaka zvinogonawo kuita basa.
Izvozvo zvinoreva kuti mwana wako angangodaro akagara nhaka yezvakaberekwa zvehutori ye fibromyalgia , asi izvo zvakadaro hazvirevi kuti iye achazoguma nawo. Zvinotora imwe mamiriro ezvinhu ezvinhu kuti uvatore pasi iyo nzira.
Genetic Links muFibromyalgia
Vatsvakurudzi vakatanga kutarisa kune maitiro ezvigadzirwa zve fibromyalgia kare kare nekuti inowanzotiza mumhuri, mune izvo zvinonzi "masumbu". Zvakawanda zvebasa zvakabatanidza mapatya akafanana. Mutumbi wekutsvakurudza wakanga uchikura kubvira kuma1980.
Zvatakadzidza ndezvokuti hafu yezvengozi inotsanangurwa nejeneti uye hafu inotsanangurwa nezvimwe zvinhu zvakadai zvakanyorwa pamusoro apa.
Kutsvakurudza kunosimbisa huwandu hwezvakaitika mumhuri uye hunoratidza kuti chirwere chinorwadza (iyo pfungwa iyo inonzwa inorwadza) inowanikwa mune zvisingaiti zve fibromyalgic dzevanhu vane fibromyalgia.
Tiri kutotanga kuwana mifananidzo yemhando chaiyo yezvinyorwa zvine chokuita ne fibromyalgia.
Kusvika ikozvino, tine zvidzidzo zvakawanda zvinoratidza kubatana nemamiriyoni akawanda, asi zvizhinji zvezviongorori izvi hazvina kudzokororwa.
Genetic kusagadzikana kwakave kwakarongedzwa neongororo yepakutanga inosanganisira mazamu anobatana neurotransmitters (makemikari vatumwa muuropi) ayo akabatanidzwa mu fibromyalgia, kusanganisira serotonin , norepinephrine , dopamine , GABA uye glutamate . Vamwe vanobatanidzwa muhutano huzhinji hunoita, kurwisana nehutachiona hwehutachiwana, uye hutachiona hutachiwana hunobata maopioid (vanouraya marwadzo anokonzera narcotic) uye zvinokonzerwa nemakumbo (sezvinoita marijuana .)
Sezvatinodzidza zvakawanda pamusoro pemasangano emagenzura, vatsvakurudzi vanogona kuziva kuti ndeupi weiwo anokonzera njodzi yekuvandudza fibromyalgia uyewo kana chero ipi zvayo inogona kushandiswa kuongorora kana kubata chirwere chacho.
Izvozvo Zvinorevei Kune Mwana Wako?
Zvinotyisa kufunga kuti mwana wako ane ngozi yakakura yokuguma ne fibromyalgia. Chinhu chinokosha chokuyeuka ndechokuti hapana chakavimbiswa.
Kusvika ikozvino, hatizivi zvingabatsira kuderedza dambudziko, asi kumwe kuongorora kunoratidza kuti mapatya ane humwe huchenjeri hwepfungwa akanga asingakwanisi kurwara. Unyanzvi hwako hwepfungwa ndewekugona kwako:
- kuti uzive uye mukudzora kwekunzwa kwako
- kuti utaure manzwiro aunoita
- kutarisana neukama hwakanaka uye hwekunzwisisa
Kukurudzira unyanzvi uhwu mumwana wako kunogona kubatsira. Kushushikana mupfungwa kunokonzera kukanganisa, saka edza kudzidzisa mwana wako zvakanaka kugadzirisa matanho . Kana mwana wako achiita seanonetseka nechimwe chezvinhu izvi, unogona kutsvaga mupi wemazano wezvesa anogona kumubatsira.
Nokuti kusati kwagara kuripo kunorwadziwa kusingaperi kunokonzera ngozi ye fibromyalgia, unogona kunge uchida kunyatsoziva kuti kukuvara kunoporesa sei kana mwana wako ane migraines kana "kukura kurwadziwa." Chiremba wevana vako anofanira kukwanisa kurumbidza kurapwa.
Isu hatina uchapupu hwokuti kudya kwakanaka uye hutano hwakanaka hunoita kuti udzikise mwana wako pangozi yekuvandudza fibromyalgia, asi ivo nguva dzose vane pfungwa yakanaka.
Kana iwe uine hanya nezvinhu zvose zvine chokuita nehutano hwemwana wako, iva nechokwadi chekuunza nayo nevana vako.
Uye yeuka kuti iwe hauna "kuparadza" mwana wako pane chimwe chinhu. Kutaura zvazviri, kuziva kwako kwokutanga kungave ndiko kunovatungamirira mune imwe nzira.
Sources:
Becker RM, uye. al. Revista brasileira de reumatologia. 2010 Dec; 50 (6): 617-24. Sangano pakati pemhando yezvakatipoteredza, kushungurudzika uye APOE magenhi akasiyana-siyana mu fibromyalgia kugadziriswa kusarudza.
Burri A, Lachance G, Williams F. Twin tsvakurudzo uye genetics yevanhu. 2015 Mbudzi; 18 (2): 188-97. A discordant monozygotic-wtin nzira yezvinhu zvinogona kuisa mungozi yehutachiona husingaperi hwevakadzi.
Matsuda JB, et. al. Revista brasileira de reumatologia. 2010 Apr; 50 (2): 141-9. Serotonin receptor (5-HT 2A) uye catechol-O-methyltransferase (COMT) maitiro ekugadzirisa maitiro emagetsi: zvinokonzera fibromyalgia?
Reeser JC, et. al. PM & R: iyo magazini yekukuvara, basa, nekuvandudza. 2011 Mar; 3 (3): 193-7. Apolipoprotein e4 genotype inokonzera njodzi yekuve nedhiabnosed ne posttraumatic fibromyalgia.
Xiao Y, He W, Russell IJ. Nyaya ye rheumatology. 2011 Jun; 38 (6): 1095-103. Genetic polymorphisms ye beta2-adrenergic receptor inobatanidza ne guanosine protein-yakagadziriswa stimulator receptor kudzvinyirira mu fibromyalgia syndrome.