Kukwana kweZvirevo zvekutsvaga zvinotarisana nekugadzirisa uye vanhu
Iko CD4 / CD8 yehuwandu inofanirwa kuongororwa kwemasimba evanhu, nekuenzanisa chikamu che "helper" CD4 T-cells kune "suppressor" CD8 T-cells. A prognostic valuation inofanirwa kutarisa chinangwa chechirwere, semunhu kana ane HIV .
Kunzwisisa Maitiro akaita CD4 neCD8 T-Cells
CD4 neCD8 zvinongova zviviri zviviri zvakasiyana-siyana zveglycoprotein zvakawanikwa pamusoro peT-cells nedzimwe lymphocytes (boka remasera machena eropa riri pakati pesimba rekudzivirira muviri).
CD4 T-seli dzinonzi "vabatsiri" nokuti ndivo ndivo vanoita kuti maitiro ezvirwere zvemuviri vatarise mushure mekutarisana ne-pathogen (infective agent).
Kana izvi zvichiitika, CD8 "suppressor" T-seli inoshandiswa kurwisa nekuuraya zvirwere izvi. Ivo vanozoita nekuvhara basa reCD4 apo maitiro edziviriro ezvirwere zvekuzvidzivirira akawanikwa.
A CD4 / CD8 ratio inonzi yakasununguka kana iri pakati pe 1.0 ne 4.0. Mune munhu ane utano hwakashandura kusvika pakati pe30-60% CD4 T-seli uye 10-30% CD8 T-seli.
Zvisinei, apo munhu anotanga kutapukirwa neHIV , pane kazhinji inodonha 30% muwandu hweCD4 T-seli seAIDS inotarisira masero aya uye inoderedza nhamba yavo. Kusiyana neizvi, yeCD8 T-seli inowanzowedzera nekusvika 40% panguva, kunyange zvazvo kukwanisa kwavo kuvharidza hutachiona huchapedza nguva yakawanda sezvo pane zvishomanana CD4 T-seli zvingakonzera mhinduro inoshanda.
Apo antiretroviral therapy (ART) inotangwa panguva yakakodzera kune munhu ane HIV, chiyero chinowanzodzokera kune chaiyo.
Zvisinei, kana kurapa kunonoka, simba remuviri wekugadzirisa CD4 T-seli rinowedzera, uye chiyero chinowanzosara pasi pe 1.0.
Zvinonzi CD4 / CD8 Ratio Inotiudza
Izvo zvinonzi prognostic kukosha kweCD4 / CD8 inofungidzirwa kusingabatsiri kune vatungamiri veHIV kupfuura yaive makore makumi maviri apfuura, apo pakanga pane zvishomanana, zvisingashandisi ma antiretroviral zviripo zvekutapurira HIV.
Kunyange zvazvo inogona kuratidzira nguva yehutachiwana uye hwekufananidzira kwehutano hwehutachiwana hweHIV , kunyanya kusimbiswa nhasi kunowanikwa mukuchengetedza chirwere cheropa rehutachiona (sezvinoyerwa nehutachiona hwehutachiwana hwevanhu) kuitira kuti kuderedza kufambira mberi kwezvirwere uye kudzivisa kukura kweHIV muropa kushorwa .
Nezvo zvichitaurirwa, kuwedzera kwekutarisa kuri kuiswa kuCD4 / CD8 simba muhutachiwana hweHIV . Zvidzidzo zvekare zvekuchirapa zvakaratidza kuti varwere pahutano hwakanaka, kwenguva yakareba ART nehuwandu hweCD4 / CD8 yehuwandu hune huwandu hwekusava nehutachiona hweHIV hune hutano uye hunofa.
Kune dzimwe nzvimbo dzinoverengeka apo chidimbu cheCD4 / CD8 chingave chakakosha. Muongororo yepidemiological, inogona kushandiswa sechinhu chakanaka nacho kuti uone kuwanda kwemhepo (kureva, kukwanisa kwechirwere chepachigoni kukonzera zvirwere) zveHIV mune vanhu vakasiyana kana kupfuura kwenguva.
Inogona kushandiswa kufanotaura kuitika kwe IRIS (immune reconstitution inflammatory syndrome) iyo dzimwe nguva inogona kuitika apo munhu anotanga chirwere chetachirwere chetachiona. Kana nhamba yekutanga yeCCD4 yakaderera uye inofambidzana nechikamu chakaderera cheCD4 / CD8 chiri pasi pe 0,20, mikana yeitiko ye IRIS inowedzera zvikuru.
Saizvozvowo, kutsvakurudza kwakaratidza kuti pasi reCD4 / CD8 inowanikwa mumucheche akaberekerwa vanaamai vane hutachiona hweHIV ndeyekufananidzira kana mwana iyeye ari seroconvert (ave nechokwadi cheAVH-positive) , uye mukana unowedzera zvinoshamisa apo chiyero chiri pasi pe 1.0.
Izvi zvinogona kunyanya kukosha munyika dzichiri kusimukira apo nhamba yekutumira vana kumwana kusvika kumwana yakaderera zvikuru asi nhamba yevana vanotapukirwa nehutachiona hweHIV inoramba yakakwirira.
Sources:
Mahnke, Y .; Greenwald, J .; DerSimonian, R .; et al. "Kuwedzera kusarudzwa kwemasvomhu eCDP-specific specific HIV-1 vane varwere vane hutachiona hwekudzivirira zvirwere zvekudzivirira zvirwere." Ropa. March 29, 2012; 119 (13): 3105-3112.
Zijenah, L .; Katzenstein, D .; Nathoo, K .; et al. "T lymphocytes pakati pehutachiona hweHIV uye-isina kuonekwa: chiyero cheCD4 / CD8 sechinhu chinogona kuongororwa nehutachiona mucheche pasi pemakore maviri . " Journal of Translational Medicine. 1 February 2005; 3: 6: doi: 10.1186 / 1479-5876-3-6.
Seng, R .; Goujard, C .; Krastinova, E ;; et al. "Kuchinja kwehupenyu hwehupenyu hweHIV viremia kwenguva refu yekudzikinura CD4 + kuwanda uye CD4 + / CD8 + chiyero pakati pevarwere vari pamwe chete neraretroviral therapy." AIDS . January 13, 2015; yakabudiswa mberi kwekudhinda; DOI: 10.1097 / QAD.0000000000000571.