Zvirwere zvakawanda zvinokwegura zvinoona makore 10 kusvika ku15 apfuura
Utachiona hweHIV hunozivikanwa nekushandiswa kwenguva refu kwenguva refu, iyo muviri unopindura kuvepo kwehutachiona kuburikidza nekudzivirira zvirwere zvinodzivirirwa uye mapurogiramu anokonzera kupisa. Izvo zvakanyanya kukurudzira immune kushandiswa uye kuramba zvichiramba, kusingaperi kupopota kunobatanidza neHIV kunoonekwa sevatambi vakakurumbira mukukwegura, zvichikonzera utera husina nguva uye zvirwere zvinosakara.
Izvi zvinowedzera kukurumidza inowanzonzi senescence isati yasvika .
Kusarudza Kukwegura uye Kutanga Kukura
Premature senescence inotsanangurwa sehutano hwehupenyu hwemunhu kana hupenyu panguva yakawanda kare kupfuura zvaatararisirwa kana kuti kune ruzivo rwehuwandu hwevanhu.
Zvichida kutaura, kukwegura kunoratidzirwa nemuviri wakaderedza simba rekutarisana nematambudziko, zvichiita kuti zvive zvakaoma kuchengetedza bias stasis (equilibrium), nekuwedzera dambudziko rekukwegura-zvirwere zvakadai seAlzheimer's or metabolic bone disorders. Kutanga kusvika senescence kunoreva kuti muviri unenge wachembera zvakanaka nguva isati yasvika uye inowanzobatanidzwa kune rimwe kana kuti zvimwe zvinokonzera causal kana zviitiko.
Kukwegura kwemazuva ose kunobatanidza nekusingaperi, kupera kwemakirasi-kuvhiringidzika-kunonzi inflammaging -iyo inobatsira mukuderera kwekukura kwemasero, pamwe nekurasikirwa zvishoma kwezvinhu zvinoshandiswa. Izvo zvinogadzirwa nekukwegura zvinofungidzirwa, uye zvakakura, zvisingadzivisiki, kunyange zvazvo zvizvarwa, zvakatipoteredza uye zviitiko zvine chokuita nemakore zvinogona kugadzirisa kushaya kwoga kwekukwegura nekufa.
Kusiyana neizvi, premes senescence inosanganiswa nekusingaperi kusuruvara kunokura kune iyo inowanikwa mumwero, munhu ane hutano. Iyi nhamba yakakwirira yekurwisana kusingaperi inogona kukonzera kukuvadzwa kwema cell uye molecular level, kuisa masero pasi pekushungurudzika kwehutano kune kwavasingagoni kuderedza muviri kana kugadzirisa kukanganisa.
Kuvhiringidza kunogona kukanganisa zvakananga majeni kune uko mazita ekunyora kwemasero akachinja zvachose-zvinowanzoitika muchitokisi kufa kana kukura kwekuchinja kwekenza. Nokufamba kwenguva, masero akabatwa anomira kugovana zvachose, uye muviri wose wakakwana chaizvo.
Kutanga kusangana kwechisimba kunokonzerwa nehumwe hutachiona, pamwe chete nemafambiro akaita sekusvuta nekurema, kana kuti zvakatipoteredza zvakadai sekusvibisa kana kupisa kwezuva.
Premature Senescence neHIV Infection
Sezvo vanhu vane HIV vachigona kutarisira kurarama hupenyu hwepedyo huri pedyo-hwemazuva ose, vachipiwa kutanga kwe ART, kunyanya kuisa pfungwa pakuiswa kune dzakawanda zvirwere zvisingawaniki neHIV zvinogona kutora zvakawanda zvezvikwereti. Kutaura zvazviri, munyika dzakawanda dzakagadzirwa, zvirwere zvinokonzerwa nekudzivirirwa kwezvirwere-izvo zvinonzi zvinokonzera zvirwere-hazvisisiri vaurayi vevanhu vane HIV.
Pane kudaro, maitiro evanhu vasina hutachiona hweAIDS nhasi anoonekwa sechikonzero chikuru chekufa kwevanhu vanotapukirwa nehutachiwana muNorth America neEurope, uye vazhinji vanowanikwa makore gumi nemaviri mberi kwevasiri vavo vasina HIV. Saizvozvowo, kukanganiswa kwehutano hwepfungwa kunobatanidza nekukwegura kunoonekwa kune vanhu vane HIV mune makore anopfuura makumi mana, asi nguva yepakati yemasikirwo emakemikari (kurwadziwa kwemoyo) inomira makore makumi mashanu chete-makore manomwe kusvika 16 zvisati zvaitika kune varume vasina vakadzi kana vakadzi.
Kunyange kana HIV ichichengetedzwa zvakanaka nenzira ye antiretroviral therapy (ART) , vanhu vanotapukirwa neHIV vanenge vachiri kutarisana nehutano hwekukwegura-hunosangana nehutano, kunyange nehuwandu hwakaderera.
Varwere vane ART epakutanga uye ma CD4 nedir akakurumbira vanowanzoonekwa sevari pasi pemutoro muduku wechirwere chisingaperi kupfuura avo vanotanga kurapwa kwenguva refu, apo varwere vane utachiona hwehutachiona hwehutano vanoonekwa sevasingatambudziki nemafungiro ehutano hwemakore kupfuura vanhu vasingateereri kana vasingagoni kuti zvive nehutachiona hwekuderedza.
Kutanga kuongororwa uye kurapwa ndizvo, zvino, chinhu chinokosha kukurumidza kuchera kusati kwasvika kazhinji kune vanhu vane chirwere cheHIV kwenguva refu.
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