Iyi Mishonga Inoshandiswa Kuita Maitiro Akawanda Anowanzoita Zvirwere
Nezve Methotrexate
Methotrexate mishonga inopesana nesero metabolism, saka inoshandiswa kurapa maitiro apo kukura kwemasero kunoda kubviswa, zvakadai sa psoriasis nekenza. Methotrexate inoderedzawo maitiro ezvirwere zvemuviri, ndicho chikonzero inorongedzerwa nemamiriro ezvinhu ega ega ehurmatoid arthritis uye chirwere chinoputika (IBD) .
Methotrexate inogona kuva inoshanda, uye inowanzochengetedza mishonga yakachengeteka, asi inotora rurefu rurefu-runovhiringidza migumisiro. Vanhu vane IBD havawanzogashirwi ichi chirwere mumitambo yakakwirira, saka, kunyange zvazvo zvose izvi zvinokonzerwa nemigumisiro inobvira, vanhu vanozvitora kuBD havawanzozvikudziridza. Methotrexate inofanira kutorwa chete pakubvunzurudzwa kwepedyo uye nekufambidzana kwakanyanya kubva kunechiremba uye chero ipi zvayo nemigumisiro yese inofanira kukurukurwa nachiremba wako.
Nyaya Inonyanya Kukosha Nezve Methotrexate
Methotrexate inorondedzera mashoko inouya neicho chinonzi black box warning. Ichi chirevo chakakosha kumusoro kwe methotrexate inorondedzera ruzivo rwakapoteredzwa nehurukuro (iyo inowanzonzi "black box"). Irobhokisi bhenekeri nyevero ye methotrexate yakareba kwenguva refu, uye inogona kunge inotyisa. Kana pane zvinonetsa, taura nachiremba pamusoro pezvipingamupinyi zve methotrexate pamwe nezvinobatsira kuhutano.
Ngozi yemamwe matambudziko angava akawanda kana zvishoma, uye chiremba chete anogona kubatsira kuisa izvozvi mukutarisa. Zvakare, zvakakosha kuti chiremba anzwisise zvinetso zvemunhu mumwe nomumwe nokuti murwere wese achave akasiyana.
Methotrexate inogona kukonzera kukanganisa kwakakomba kuberekwa uye haifaniri kutorwa panguva yekudzivirira kana kuti nevakadzi vanozvironga kuva nepamuviri. Izvi zvinokonzerwa nehutano hwekuremara kwekuberekwa kana kufa kwekufa.
Kana iwe ukava nepamuviri paunotora methotrexate, zivisa chiremba wako pakarepo.
Zvimwe zvemashoko makuru anotsanangurwa mubhokisi bhokisi nyevero ndei:
- Methotrexate inofanira kungoshandiswa pasi pekutarisirwa kwechiremba akawana kushandiswa kwemishonga ye antimetabolite
- Methotrexate inofanira kushandiswa chete munyaya ye "kudzivisa zvirwere" izvo zvisingabvumi kune imwe kurapa
- Varwere vanoda kugara vachiongororwa nezvezvinhu zvinosvibisa (kunyanya bone marrow, chiropa, mapapu, uye itsvo)
- Vanachiremba vanofanira kudzidzisa varwere pamatambudziko erapi ne methotrexate
- Methotrexate haifaniri kushandiswa nevakadzi varipo kana kuti vachave vane pamuviri
- Varwere vane manzwiro ekudzosa, ascites, kana kuti kunyunyuta kunoda kuongorora zvakanyanya
- Zvinokonzerwa neutachiona zvakave zvichinzi kune vanhu vanotora mishonga yakakura ye methotrexate pamwe chete nedzimwe nhengo dzisiri dzisina kuvhiringidza (NSAIDs)
- Kushandiswa kwenguva refu kwe methotrexate kunogona kukonzera hepatotoxicity, fibrosis, cirrhosis, uye enzyme yakakwirira yeropa
- Chirwere chakaremara chave chichirondedzerwa, uye chero zviratidzo zvakadai sokukanganiswa kwakaoma, zvinofanira kuongororwa
- Kana chirwere uye chironda chekuonda chichiitika, mushonga unoda kumira
- Malignant lymphomas inogona kuitika, asi inogona kushanduka apo mushonga wacho wakamira
- Tumor lysis syndrome yakataurwa uye inogona kuvharirwa kana kurapwa
- Kugadziriswa kweganda ingangodaro, kazhinji mukati memazuva ejojo
- Zvirwere zvakataurwa, kunyanya Pneumocystis carinii pneumonia
- Pane ngozi yekunyora mutsara necrosis uye osteonecrosis apo methotrexate inoshandiswa ne radiotherapy
- Kushandiswa kweproton pump inhibitors (PPIs) kunogona kuwedzera nguva ye methotrexate iri mumuviri
Temporary Side Effects
Tarisa nechiremba wako kana chimwe chezvikamu zvinotevera zvinopfuurira kana zvinotambudza:
- Acne
- Mabhira
- Kusava nenzara
- Nausea kana kurutsa
- Pale pepa
- Kunzwa kwezuva
- Itching kana kukurumidza
- Kurasikirwa bvudzi kwenguva pfupi
Zivisai Dako Rako kana Wakawana
- Kutambudzika shure
- Mvura yakasviba
- Chizutu
- Kukurova
- Headache
- Kusakwana kusimba kana kuneta
- Maso matsvuku kana ganda (jaundice)
Zivisai Dhirere Yako Pakarepo kana Iwe Uchiwana
- Diarrhea
- Kudzikinura ganda
- Masonda pamuromo nemiromo
- Dumbu remarwadzo
Zvisinganyanyi Kuwirirana Kana Zvakare
- Allergic reaction
- Chiratidzo chakasvibiswa
- Chest pain
- Kusanganiswa
- Vakafa kana kuti vakasununguka ganda mapfupa
- Fever kana chills
- Ita mavara matsvuku paganda
- Zvinorwadza kuonekwa kwechivara cheganda
- Zvinorwadza kana zvakaoma kuramba
- Blisters tsvuku kana muronda pamuromo, muromo, ziso, nhepfenyuro, uye marital area
- Kudzikinura ganda kana kuti kusina bvudzi kurasikirwa
- Kugumburwa (kunetseka)
- Kusuruvara kwekupema, kufukidzwa, kumira kana kuvhara
- Kunze kana kuchera kurwadziwa shure
- Kusunungura ganda, musuru uye bone
- Kubuda ropa kusina kujairika kana kuputika
Dzimwe mimwe migumisiro isina kunyorwa pamusoro apa inogonawo kuitika pane vamwe varwere. Kana ukacherechedza zvimwe zviitiko, tarisa nechiremba wako. Iyi ruzivo inongororwa semutungamiri - nguva dzose uongorore chiremba kana mhizimisi kuti uwane ruzivo rwakakwana pamusoro pemishonga yekurapa.
> Sources:
> Hospira, Inc. "Methotrexate Injection, USP." FDA.gov. Oct 2011.
> Roxane Laboratories. "METHOTREXATE Matethe USP, 2.5 mg." Boehringer-Ingelheim.com. Sept 2015.