Zviratidzo, Kuongororwa, uye Kurapa Ongororo yeLymphoplasmacytic Lymphoma
Chii chinonzi macroglobulinemia yeWaldenstrom uye chii chaunoda kuziva kana iwe uine chirwere ichi?
Waldenstrom Macroglobulinemia - Tsanangudzo
Waldenstrom macroglobulinemia (WM) rudzi rusingawaniki rwevasiri Hodgkin lymphoma (NHL) . WM chirwere chinokanganisa B lymphocyte (kana kuti masero B) uye inoratidzwa nehuwandu hweprotein dzinonzi IgM antibodies.
WM inogona kutumidzwawo seWaldenstrom's macroglobulinemia, primary macroglobulinemia, kana lymphoplasmacytic lymphoma.
Mune WM, kenza yesero isina kuitika inowanikwa muB lymphocytes vasati vakura mumasero emu plasma. Masero eplasma anokonzera kutakura utachiona-kurwisana nemasikirini emaproteni. Nokudaro, nhamba yakawedzerwa yemasero aya inotungamirira kuwandu hwechirwere chinonzi antibody, IgM.
Zviratidzo nezviratidzo zveWM
WM inogona kukanganisa muviri wako nenzira mbiri.
Tsipa marora achikwira. I-lymphoma cells inogona kukanganisa mafupa ako, zvichiita kuti zvive zvakaoma mumuviri wako kuti uwane nhamba yakakwana yeplatelets, masero matsvuku eropa, uye masero machena eropa . Somugumisiro, kukanganisa uku kunokonzera zviratidzo uye zviratidzo zvinowanzoita anemia (aine tsvuku tsvuku yeropa kuverenga), thrombocytopenia (pasi shomare count), uye neutropenia (yakaderera neutrophil count - neutrophils imwe yeropa rechechi yeropa) . Zvimwe zvezviratidzo izvi zvinogona kusanganisira:
- Kusasvibiswa kana kusingazivikanwi kubuda ropa, zvakadai sekubuda ropa, maronda anoshamisa, kana nosebleeds
- Unonzwa usingawanzwi wakaneta, kunyange iwe uri kuwana hope yakakwana
- Kupfupika kwemweya nemhando ipi zvayo
- Kuramba uine zvirwere kana chirwere chausingaoneki kurwisa
- Pale pepa
Hyperviscosity . Mukuwedzera kumigumisiro yaro pamapfupa emapfupa, kuwedzera kweprotein ye IgM muropa rako kunogona kukonzera izvo zvinonzi hyervervosity.
Muchidimbu, kufungidzirwa kunoreva kuti ropa rinova rakaoma kana gooey uye rinogona kuoma kunyura nyore nyore kuburikidza nemidziyo yeropa. Kunyengera kunokonzera imwe zviratidzo zvakasiyana siyana zvezviratidzo zvinosanganisira:
- Kuchinja mune zvakaratidzwa, zvakadai sehuturi kana kuwedzera kwekuona
- Mamiriro ezvinhu emamiriro ekuchinja, akadai sekuvhiringidzika
- Chizutu
- Headaches
- Unhu kana kumira mumakumbo kana maoko
Sezvimwe nemamwe marudzi e-lymphoma, kenza dzemasere dzinogona kuva mune dzimwe nzvimbo dzomuviri, kunyanya mupleen uye chiropa, uye zvinokonzera kurwadziwa. Kuvhara lymph nodes kunogona kuvapo zvakare.
Iwe unofanira kuyeuka kuti zviratidzo izvi uye zviratidzo zvinogona kuva zvisinganzwisisiki uye zvinogona kunge zviripo mune mamwe mimwe mitemo yakaoma. Kana uchinetseka pamusoro pekuchinja kupi kune hutano hwako, nguva dzose zvinonakidza kutaurirana nachiremba wako kana mutarisiri wehutano.
Chii Chinokonzera WM?
Sezvakaitika kune mamwe marudzi mazhinji ekenza, hazvizivikanwe chii chinokonzera WM. Zvisinei, vatsvakurudzi vakaona zvimwe zvinhu zvinoratidzika sezvakajairika kune vanhu vane chirwere. Zvizivikanwa zvinowanzoitika zvinosanganisira:
- Zera rinopfuura makore 60
- Nhoroondo yemamiriro ezvinhu anonzi monoclonal gammopathy yekusagadziriswa kunokosha (MGUS)
- Nhoroondo yeWM mumhuri yavo
- Kuva nehutachiona hweH hepatitis C
Mukuwedzera, WM inowanikwa mune varume kakawanda kupfuura vakadzi, uye muCaucasian vanhu kakawanda kupfuura Africa Africa.
Kuongororwa WM
Sezvimwe nemamwe marudzi eropa nemararamiro emarro, WM inowanzoongororwa inoshandisa kuongorora ropa uye bone marrow biopsy uye aspirate .
Kuzara kweropa kuverenga kungaratidza kuderera kwemajeri emasero ehutano ane utano hwakanaka, akadai semasero matsvuku eropa, maplatelet, uye masero machena eropa. Mukuwedzera, kuongorora kweropa kucharatidza kuwedzera kwehuwandu hweprotini yeG IgM.
Tora marora inopisa uye aspirate ichapa tsanangudzo pamusoro pemhando dzemasero mumuro, uye kubatsira chiremba kusiyanisa WM kubva kune mamwe maitiro e-lymphoma.
WM Wakaitwa Sei?
WM rudzi rwusingawanzwisisiki rwekenza, uye vatsvakurudzi vachiri nenzira yakareba yekuenda mukudzidza nezvemaitiro akasiyana-siyana ekurapa anowanika, uye kuti vanofananirana sei kune umwe neumwe maererano nekubudirira kwavo. Somugumisiro, vanhu avo vachangobva kuongororwa neWM vangasarudza kupinda muchirongwa chekurapa kubatsira masayendisiti mukunyatsonzwisisa nezvechiitiko ichi.
Iko hakuna chirwere chakazivikanwa cheWM panguva ino, asi kune dzimwe nzira dzakasarudzwa dzakaratidza kubudirira mukudzora chirwere chacho.
- Plasmapheresis: Iyo yakawandisa yakakura yeGGM muropa inogona kukonzera kugadzirisa kana kuwedzera kweropa. Iri ropa rakawanda rinogona kuita kuti zvive nyore kune zvinovaka muviri uye oksijeni kuendeswa kune ose masero emuviri. Kubvisa zvimwe zveIgM kubva muropa zvinogona kubatsira kuderedza kuwanda kweropa.Pakati plasmapheresis , ropa romurwere rinoparidzirwa zvishoma nezvishoma nemushini unobvisa I-IgM ndokudzoka mumuviri wavo.
- Chemotherapy uye Biotherapy: Varwere vane WM vanowanzobatwa nekemotherapy. Kune hutano hwakasiyana-siyana hwemishonga inogona kushandiswa. Zvimwe zvacho zvinosanganisira kuunganidza Cytoxan (cyclophosphamide) pamwe neRituxan (rituximab) uye dexamethasone, kana Velcade (bortezomib) pamwe neRituxan uye dexamethasone. Kune dzimwe dzakawanda mishonga uye kusanganiswa kwezvinodhaka kushandiswa kurapa WM zvose mukuita uye mumakiriniki.
- Sero reStem Transplant: Hazvizivikanwi kuti chinokonzerwa neiyo shina chekushandiswa kwema cell inotamba mukurapa WM. Zvinosuruvarisa, kukwegura kwevamwe varwere veWM kunogona kugadzirisa kushandiswa kwechirwere cheallogeneic, iyo inogona kuva nemigumisiro yechipfu, asi autologous transplant mushure mekuwedzerwa kwe-high-dose chemotherapy inogona kuva yakakodzera uye inoshanda, kunyanya kune avo vanodzokororazve chirwere chavo .
- Splenectomy: Kufanana nedzimwe mhando dzeNHL, varwere vane WM vangave vane spleen yakakura, kana splenomegaly. Izvi zvinokonzerwa nekuvaka-up kwe-lymphocytes mu spleen. Kune vamwe varwere, kubviswa kwepleen, kana splenectomy, kunogona kupa ruregerero kubva kuWM.
- Tarisai uye Mumirira: Kusvikira WM iri kukonzera matambudziko, vazhinji vanorinikiti vachasarudza "kurinda uye kumirira" nzira yekurapa. Muchiitiko ichi, iwe ucharamba uchicherechedza zvakanyanya neunyanzvi hwako uye unonoka mamwe maitiro ekurwadza (uye zvinosanganiswa nemigumisiro) kusvikira iwe uchida chaizvo. Kunyange zvazvo zvichigona kunge zvakaoma kufungidzira kuenda kuburikidza nehupenyu hwezuva nezuva nekenza mumuviri wako uye kwete kuita chimwe chinhu pamusoro pacho, kutsvakurudza kwakaratidza kuti varwere vanonoka kurapwa kusvikira vatanga kuva nezvinetso kubva kwavari havana mamiriro akaipisisa kupfuura avo vanhu vanotanga kurapwa pakarepo.
Kuisa pfungwa yacho kumusoro
Waldenstrom macroglobulinemia, kana WM, iyo inonyanya kuwanikwa yeNHL iyo inongorapwa mune vanhu vanoda kusvika 1 500 muUnited States. Icho kenza inobata bymymorphic B uye inokonzera kuwandisa kwepamusoro kwechirwere chechirwere muropa.
Nemhaka yekuti haina kujairika, uye nokuti ruzivo rwedu rwerymymma rinowedzera kuwedzera, pane iye zvino hapana kana imwe yero yehutano yepamusoro yeWM. Nokudaro, varwere vakawanda avo vachangobva kuongororwa neWM vanokurudzirwa kuti vabatanidzwe mumakiriniki ekutungamirira kubatsira masayendisiti kudzidza zvizhinji nezvekenza iyi isina kukodzera yeropa, uye mune tariro yokuti vachave nemukana wekushandisa mishonga ikozvino iyo ichava yakakwana mu ramangwana.
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