Michael J. Fox, 54, anozivikanwa nezvinhu zvakawanda. Muiti wemhizha, akawana mubayiro webasa rake mu "Mhuri dzeMhuri," "Spin City," uye "Mukadzi Akanaka." Zvisinei, kubudirira kwaPex kwakanakisisa - Grammy yake, Emmys, uye Golden Globe Awards kunze - ingave basa rake pakuparadza chirwere cheParkinson. Mutori wenheyo akasimbisa Michael J. Fox Foundation yePasinson's Research (MJFF) mugore ra2000, makore mapfumbamwe mushure mekunge vaongororwa vane chirwere.
Kubva kugoverana nehutano hwake nehuruzhinji muna 1998, Fox ataura achifarira stem cell tsvakurudzo uye akashanda nesimba kuti awane mari yekutsvakurudza. Fox ikozvino inoshanda semusunguri wesangano uye inogara pabhodi revatungamiri.
Michael J. Fox Foundation yePilinson's Research
Michael J. Fox Nheyo yeChishopu yePacinson yakatsaurirwa kuwana mushonga wePalinson's disease. Kusvika iye zvino, nheyo dzakasimudza mamiriyoni 450 kubva pakutsvakurudza kwaPacinson. MJFF inotarisirawo kukurapa kurapa kwakanaka kwezviratidzo zvisinganzwisisiki zvechirwere - sekudzivirira, matambudziko ekumedza, kutora pfungwa, nekuderera kwekuziva - pamwe chete nemigumisiro yakaipisisa yemishonga ino yaPacinson.
Chii chinonzi Parkinson's Disease?
Chirwere chePacinsinson chinokanganisa hurumende yenheyo yepamusoro inoita zviratidzo zvishoma nezvishoma, zvinokanganisa zvinokanganisa nzira iyo muviri unofamba nayo.
Chiratidzo chiratidzo chechiitiko chacho chinodengenyeka, kunyanya mumaoko. "Parkinson's" ndiyo nguva yakazara yezvikamu zvitanhatu zvakasiyana zvechirwere, izvo zvakawanda zvinowanzokonzera vanhu vanopfuura makore makumi mashanu. Mavhareji emakore ekuzivikanwa ane makore 62. Anenge mamiriyoni eAmerica vari kurarama nehosha yaPasinson.
Vanenge makumi matatu kubva muzana yevanhu vane Parkinson vaongororwa vasati vava nemakore makumi mashanu - 20 kubva muzana yevanhu ava vanoongororwa vasati vava nemakore makumi mana. Apo Parkinson inokura musati yava nemakore makumi mashanu, inozivikanwa sevechidiki muPasinson. Michael J. Fox, uyo akaonekwa kuti paaiva nemakore makumi matatu, ari munharaunda iyi.
Vanhu vane chirwere chePasinson vane kushaya kwekemikisi inobata kufamba (kunonzi dopamine) muhupi hwavo. Izvi zvinokonzerwa nekuchinja mumasero e substantia nigra, nzvimbo yeuropi inobereka dopamine. Kuchinja kweizvi kunoitika hakuzivikanwi. Nhema dzinosanganisira kukurumidza kukwegura, kukanganisa kwemazwi, uye zvakatipoteredza, pakati pevamwe. Zvichida zvirwere zvePasinson zvinokonzerwa nekubatanidzwa kwezvinhu izvi.
Kuwana Kurapa
Kurapa kwechirwere chePasinsin chave chiine mishonga inogona kuitwa dopamine muuropi (Sinemet), kana nemishonga inoratidzika inokanganisa kushandiswa kwedopamine muuropi (Symmetrel, Eldepryl). Mishonga inogonawo kusanganisira dopamine agonists (Parlodel, Permax, Mirapex, Requip), iyo inobatsira dopamine-sensitive brain cells.
Zvokuvhiya zvinoshandiswa pakushandisa zvinowanikwawo. Chimwe chezvinhu zvinowanzoshandiswa pakuvhiya ndezvepfungwa dzakanyanya kukurudzira (DBS).
DBS yakagadzirwa mumakore ekuma1990 uye zvino ndiyo nzira yakakwana yekurapa mamiriro acho ezvinhu. Kunyange zvazvo DBS inogona kubatsira kubata zviratidzo, hairi kuporesa chirwere chacho kana kuti hachigadziri kupfuurira mberi. Thalamotomy uye pallidotomy nzira, iyo inoparadza "maitiro anokonzera dambudziko" muuropi achishandisa electrode, inowanikwawo.
Sources
Michael J. Fox Foundation yePilinson's Research (2016)
The Parkinson's Disease Foundation (2016)