Apo Thy Hypothalamus Isingakwanisi Kushanda Zvakanaka
Kallmann chirwere chinokanganisa varume kakawanda kupfuura vakadzi, chinokanganisa vanenge 1 kusvika 8 000 kusvika ku10 000 varume uye 1 mu40,000 kusvika ku70 000 vakadzi munyika yose.
Kallmann syndrome inogona kupiwa nhaka kana kuti inogona kuitika mune mumwe munhu asina nhoroondo yemhuri yehutano. Iyo yakawanda inowanikwa nhaka yakagadzirwa ndiyo fomu yaX -yakabatana . Iko KAL1 geni pane X chromosome inobata fomu iyi.
Ikoko inotevera inowanikwa yakawanda inowanikwa nhaka inokonzerwa nekugadzirisa mutachiona cheKAL2 pane chromosome 8. Yakagamuchirwa mumutemo unotenderera . Yechechitatu inowanikwa nhaka yeKallmann syndrome inokonzerwa nekuchinja kwegene reKAL3 uye inotora nhaka sevotosomal rection disorder. Nzvimbo chaiyo yeKAL3 geni haisati yawanikwa.
Zviratidzo
MuKallmann syndrome, chikamu cheuropi, hypothalamus, haikwanisi kushanda zvakanaka. Izvi zvinokonzera zviratidzo zvinosanganisira:
- kukundikana kupfurikidza nekupera
- kwete manzwiro anonhuwira (anosmia) kana kuti simba rakanyanya simba rekunhuhuta (hyposmia)
- miedzo isina kufanirwa (cryptorchidism) mumarume
- peni duku ( microphallus ) muvarume
- Kusarudza kuenda kumwedzi hakuzombotanga nevakadzi (kunonzi primary amenorrhea)
- kushanya pamwe chete kwemaoko maviri (iyo inonzi bimanual synkinesis) kunokuvadza kune imwe yechishanu yevarume vane chirwere
Pane zvimwe zviratidzo zvinowanzoitika zvishoma, zvakadai sekuberekwa neine tsvete imwe chete kana kuti ane osteoporosis (masimba asina simba).
Kuziva
Kana mumwe munhu asingakwanisi kupera mumakore ekuyaruka, iye anotumirwa kune endocrinologist kuti aongorore uye atarisire. Rudzi urwu rwechiremba rinonyanya kusangana nematambudziko ehomoni uye rinokwanisa kusarudza kuti nei kuberekwa kusina kuitika.
Pane zvikonzero zvizhinji nei mumwe munhu asingakwanisi kupera mukuyaruka. Zvisinei, Kallmann syndrome ndiyo chete inobatanidza kusakwanisa kunhuwa.
Zvinowanzo nyore kuziva kana Kallmann syndrome inogona kuvapo nekuita kunhuhwira kuedza.
Kune mhando mbiri dzekunhuhwira kuedza. Mumwe anoshandisa mabhodhoro maduku ane zvinhu zvakasiyana mavari; imwe yero inoshandisa "scratch and sniff" makadhi. Miviri miviri inoshandisa zvinhu zvinoshuva zvakanyanya izvo munhu wese anozviziva, zvakadai sefivha. Kana munhu ari kuedzwa ane manzwiro ezvakanaka zvekunhuhwira, saka imwe dambudziko kunze kweKallmann syndrome iripo.
Kuongororwa kwepanyama kunoratidza kana ma testes asina kunaka kana kuti madiki madzimai aripo munhurume. Mhuri inonzi Kallmann syndrome yaizova chikonzero chinokosha chekucherechedza. Kuongororwa kweropa kunoitwa kuti uenzanise mazinga eLuteinizing hormone (LH) uye follicle-stimulating hormone (FSH), uye testosterone kana estrogen. Zvose izvi mahomoni zvakakosha pakukura kwepabonde. Zvishoma zvakanyanya maawa aya zvinoreva kuti pane dambudziko pamwe ne hypothalamus kana chirwere chepituitary muuropi.
MuKallmann syndrome, kusava nekunzwa kunhuwa kunokonzerwa nekusavapo kwezvivako zvinonzi olfactory bulbs muuropi. A magnetic resonance imaging (MRI) scan ye musoro inogona kuratidza kana zvivako izvi zviripo kana kwete.
Kurapa
Kurapa kweKallmann syndrome inotarisa kuisa mahomoni asina kuwanikwa.
Kune varume, kana testosterone kana hCG inopiwa nejojo panguva. Kune vakadzi, isradiol mapiritsi anotorwa zuva nezuva. Mapiritsi ePresterone anotorwawo zuva rimwe nerimwe kwemazuva 14 okutanga emwedzi mumwe nomumwe kuti aite kumwedzi. Imwe nzira yokutora mapundu maviri emapiritsi ari kushandisa mapiritsi emishonga aneserogen uye progesterone. Kune varume nevakadzi, mamwe marapirwo anowanikwa mukushaya vana. Kurapa kwakakodzera kwevanhu vane Kallmann syndrome vanovabvumira kuti vabudirire hutano hwakanaka hwekubereka.
Sources:
> AbuJbara, Mousa, Hanan Hamamy, Nadim Jarrah, > Nadima >> Shegem >, & Kamel Ajlouni. "Kliniki uye nhaka yenhoroondo dzeKallmann syndrome muJordan." Utano Hwakaberekwa 1 (2004): ePub.
> "Kallmann Syndrome." Darease Disease Database. National Organisation for Rare Disorders. 6 Feb 2008
> Saunders, Mark. "Kunzwisisa Kallmann's Syndrome - Mibvunzo Yenyu Inopindurwa." HYPOHH.net. 1997. HYPOHH.net. 6 Feb 2008