Zvimwe zvinokonzera kenza yepancreatic hazvizivikanwe, asi njodzi dzinogona kusanganisira makore, zvepabonde, dzinza, maitiro ezvakaita semhuri yehutachiona, uye mararamiro ehutano akadai sekusvuta, kushandiswa kwewaini, kuneta, uye kunyange chirwere chegum.
Sezvo zviratidzo zvekenza yepancreatic isingasimuki kusvikira yasvika, zvakakosha kuziva kuti izvi zvinogona kunge zviri kukukanganisa sei panjodzi yako kuitira kuti iwe unogona kuita zvese unogona kuideredza uye wakazivisa kukurukurirana nachiremba wako.
Zvinowanzoitika Nengozi
Kuva nechigadzirisa chinokonzerwa nekenza yepancreatic hazvirevi kuti iwe uchakura chirwere. Izvi hazviiti nguva dzose "zvichikonzera" chirwere chacho, asi chinowanzoonekwa kuvanhu vanochikuridza. Saizvozvowo, vanhu vazhinji vanovaka kenza yepancreatic havangave neipi pachena ngozi. Izvozvo zvakati, iyo inowedzera mungozi yaunayo, yakawanda iwe unogona kutarisana nekenza yepancreatic pane imwe nguva muupenyu hwako.
Njodzi dzinogona kusanganisira:
Age
Ngozi yekenza yepancreatic inowedzera nezera, kunyange zvingabvira kuongororwa pazera remakore. Parizvino, nguva inenge 90 kubva muzana yevanhu vane makore anopfuura makumi maviri nemashanu panguva yekuongororwa, uye avareji yemakore ekuongororwa kuva 71.
Race
Mukenza wepancreatic unozivikanwa zvikuru kune vemavara kupfuura vatsvene, Asian, kana Hispanics, asi zvakare, inogona kuitika kune ani zvake. Vanhu veAshkenazi Jewish heritage vane ngozi yakawedzerwa, zvichida nekuda kwehuwandu hweBrCA2 kuchinja kwezvinhu.
Zvepabonde
Muchirwere wepancreatic wakanga wakanyanya kufanana nevarume kupfuura vakadzi, asi kupera kwavhara. Chirwere ichi chaingova chechidiki pane zvese muvarume.
Chirwere cheshuga
Yenguva yakareba rudzi rwechipiri chirwere cheshuga chirungo chepancreatic cancer. Chirwere cheshuga chinogonawo kuitika nguva pfupi vasati vatariswa, kazhinji kune vanhu vasina ngozi dzechirwere cheshuga.
Iyi kusangana pakati pekutanga kusatarisiri kwechirwere cheshuga kune vanhu vanopfuura makore makumi maviri nemashanu uye kenza yepancreatic yakanga yakakosha pakuongorora kwe2018 apo vamwe vanachiremba zvino vanokurudzira kuongorora kana zvichiitika.
Gum Matenda uye Kurasikirwa Kwinoino
Chirwere cheGum, chinonzi gingivitis mumutambo wekutanga uye periodontitis mumatambo akakwirira, yakatanga kutaurwa kuva nengozi yechirwere chepancreatic muna 2007. Kuongorora kwe 2017 kwakagadzirwa kusvikira nhasi kwakawanikwa kuti vanhu vaiva 75 mukana wekuwedzera kancreatic kenza kana vane nguvaontitis uye 54 kubva muzana kana vakave varasikirwa nemeno avo (edentulism). Chikonzero chacho hachizivikanwi nechokwadi, asi chinofungidzirwa kuti mamwe mabhakitiriya anogara mumuromo anoita enzyme inokonzera kuchinja mhando imwe yemhando yegene ( p53 gene mutations ) iyo inogona kutungamirira kune kenza yepancreatic.
Chronic Pancreatitis
Nhoroondo yekusagadzikana kwepancreatitis inogona kuwedzera njodzi yekenza yepancreatic, kunyanya kune vanhu vanosvuta. Hereditary pancreatitis inowanzotanga muhuduku uye inobatanidzwa nehuwandu hwepamusoro hwechirwere.
Mamwe Mamiriro Ezvokurapa
Bhakitiriya Helicobacter pylori ( H. pylori ) chikonzero chinonyatsozivikanwa chekenza yepamu, uyewo chirwere chinonzi peptic ulcer.
Zvinofungidzirwa kuti zvinogona kuwedzerawo ngozi yekenza yepancreatic. Pane humwe uchapupu hwokuti hepatitis B inokanganisa, maziso emakumbo , chirwere chenduru, uye chirwere chechiropa chinogona kubatanidzwa nehuwandu hwehutachiona hwechirwere.
Nhoroondo Yomunhu WeKenza
Vanhu vane ruzivo rwemhando dzakasiyana-siyana dzekenza zvinowanzoita kuti vave nekenza yepancreatic. Vatsvakurudzi havazive kana izvi zvakabatana nemamwe makondombera mune imwe nzira, kana kana kubatana kunokonzerwa nehuwandu hwehutano hwemakirini aya (sekusvuta).
Rudzi rweropa
Vanhu vane marudzi eropa A, B, uye AB vanoita kunge vane ngozi yakanyanya yekenza yepancreatic kupfuura avo vane rudzi O ropa.
Chemical Exposures
Kushambadzira kwepabhadharo kunofungidzirwa kuti kunopa 2 muzana kusvika ku3 muzana yepancreatic kankere, nemakemikari anonyanya kunetseka kuva chlorinated hydrocarboni uye polycyclic inonhuhwirira yehydrocarbons (PAHs). Vashandi umo ngozi yakawedzerwa yave ichinyorwa inosanganisira kushambwa kwakadzika uye vashandi vesarudzo dzevakadzi.
Genetics
Inenge 10 muzana yemakondakiti epancreatic inonzi inofanirwa uye inofananidzwa nemhuri yehupenyu hwechirwere kana kuti chinonzi genetic syndrome.
Family History
Vanhu vane mhuri yemararamiro epancreatic ndivo vanowanzoita kuti chirwere ichi chivepo. Kune chimwewo chinonzi chinonzi kenza yepancreatic yemhuri. Munhu anofungidzirwa kuti ane izvi kana vaviri kana kupfuura zvekutanga-degree hama (mubereki, mukoma kana mwana, kana mwana) kana vatatu vemhuri kana vanowedzera vakawanda (vanamainini, vanamunini, vanun'una) vane chirwere chacho.
Genetic Syndromes
Genetic syndromes inokonzerwa nekenza yepancreatic inowanzoenderana nehutano hwakasiyana-siyana. Zvizhinji zvezvipembenene zvemashoko, zvakadai seBrCA2 kuchinja kwezvinhu , zviri mumagenjini anozivikanwa sechirwere chinodzvinyirira majini . Aya majekiseni ejeni emapuroteni anogadzirisa DNA yakaora uye anogadzirisa kukura kwemasero. Syndromes inosangana nehuwandu hwehuwandu inosanganisira:
- Hereditary breast uye ovarian cancer syndrome
- Hereditary pancreatitis
- Peutz-Jeghers syndrome
- Lynch syndrome (chirwere chisina kukwana chepolposposis chekwererera, HNPCC)
- Li-Fraumeni syndrome
- von Hippel Lindau syndrome
- Familial adenomatous polyposis
- Familial atypical multiple mole mole melanoma (FAMMM) syndrome
- Ataxia telangiectasia
- Multiple endocrine neoplasia type 1 (MEN1) chirwere (neuroendocrine tumor)
- Neurofibromatosis type 1 (neuroendocrine tumor)
Lifestyle Risk Factors
Maitiro eupenyu anokwanisa kuita basa rinokosha pakuchengetedza kenza yepancreatic uye inosanganisira:
Kusvuta
Kusvuta kunowedzera mungozi wekenza yepancreatic maviri- kusvika katatu uye inofungidzirwa kuti inokonzera chikamu chetatu chematachiwana aya. Kusiyana nekenza yemapapupa, iyo iyo inopfuurira kwenguva yakareba mushure mekunge munhu apedza (uye asingadzokeri kune yakarongeka), ngozi yepancreatic cancer inodzoka kusvika kune yakasviba mukati memakore mashanu kusvika gumi ekurega.
Doro
Yenguva refu, doro rinodhaka rinoshandiswa (zvitatu kana kupfuura zvinwiwa zuva rimwe nerimwe) zvinosanganiswa nehuwandu hwehutachiona hwepancreatic. Ngozi inogona kunge yakabatana nehuwandu hunowedzera hwekuputika kune vanhu vanonwa doro rakawandisa doro (kunyanya kana kusanganiswa nekusvuta) kwete doro pacharo. Kunwa doro zvisina kufanira hazviiti kuwedzera ngozi.
Kuwedzera muviri
Kunyanya kuwandisa kana kuwedzera kunomutsa dambudziko rekenza yepancreatic inenge 20 muzana. Zvinotendwa kuti inenge imwe yepancerccatic cancer inobatana nekurema.
Kudya
Kune humwe humwe uchapupu hwokuti kudya kwemafuta akawanda, uyewo kudya kunowedzera muzvitsvuku kana kushandiswa nyama, kunogona kusanganiswa nehuwandu hwekuparara kwekenza, kunyanya apo zvikafu zvinogadzirwa pamatambo makuru. Kune rumwe rutivi, zvikafu zvakakwirira mu folic acid, zvakadai semiriwo mashizha mashizha, zvinogona kuva nekudzivirira. A 2017 kuongororwa kwezvidzidzo nezvekudya uye kenza yepancreatic yakawana kuti kudya kwekuMadokero kwakabatanidzwa ne24 muzana mikana huru yekuvandudza chirwere chacho. Kofi inogona kuwedzerawo njodzi pamwe chete.
Sedentary lifestyle
Nzira yekurarama nehupenyu, yakadai sekushanda basa redesksi, inogona kuwedzera mungozi, asi hazvina chokwadi panguva ino.
> Sources:
> American Society of Clinical Oncology. Cancer.Net. Pancreatic Cancer: Njodzi Dambudziko. Updated 12/16. https://www.cancer.net/cancer-types/pancreatic-cancer/risk-factors
> Khadka, R., Tian, W., Xin, H., na R. Koirala. Dambudziko reNjodzi, Kutarisisa Kwepakutanga uye Kuparara Kwakakwana Pamigumisiro yeChichi pakati peKancancatic Cancer uye Chirwere Cheshuga Mellitus: Kuchinja uye Kufambira Mberi, Kuongorora. International Journal of Surgery . 2018 Mar 10. (Epub mberi kwekudhinda).
> Lu, P., Shu, L., Shen, S. et al. Dhiyabhorosi Maitiro uye Pancreatic Kano Ngozi: Meta-Kuongorora. Nutrients . 2017. 9 (1) .pii: E38.
> Maisonneuve, P., Amar, S., uye A. Lowenfels. Periodontal Disease, Edentulism, uye Pancreatic Cancer: A Meta-Analysis. Annals of Oncology . 2017. 28 (5): 985-995.
> National Cancer Institute. Pancreatic Cancer Treatment (PDQ) -Patient Version. Yakavandudzwa 03/22/18. https://www.cancer.gov/types/pancreatic/patient/pancreatic-treatment-pdq