Chii chinonzi P53 uye Chinonzi Inhare Iripi muCancer?
Chii chinonzi p53 Gene?
Ndeipi chaiyo p53 geni uye inobatanidzei mukukudziridza nekufambira mberi kwekenza?
Iyo p53 Gene ndiyo Tumor Suppressor Gene
Iko p53 geni ndiyo geni inoratidzira puroteni inobvisa kukura uye kukura kwemakumbo (pamwe nemamwe mabasa). Iyo inozivikanwa sechirwere chinodzvinyirira gene . Kana iyo geni inoshandurwa-ndiko kuti, kuchinjwa neimwe nzira kuburikidza nemamiriro ezvinhu kana nhaka, masero anokanganisa anobvumirwa kurarama, uye pakupedzisira, anova kenza masero.
p53 Gene Mutation is Common
Kushandurudza mu p53 gene (inowanikwa nekromosome 17) ndiyo inonyanya kuchinja inowanikwa mumasero ekenza uye inowanikwa mu50% yekenza.
Chii chinonzi p53 Gene Do?
Iyo p53 geni inokonzera mapuroteni anogona kugadzirisa masero anenge akaora kana kukonzera masero anokanganisa kufa, chirongwa chinonzi apoptosis. Apo jeni harisi kushanda nekuda kwekuchinja, mapuroteni aya anogadzirisa masero kana kubvisa masero akakuvadzwa haana kubviswa, uye masero asina kukodzera anobvumirwa kugovana nekukura.
Nzira yakajeka yekutarisa p53 gene ndiyo yekuzvifananidza iwe se p53 geni, uye plumber seimwe yeprotini iwe unogona kudzora. Kana uine mvura yakanyorova uye iwe uri "kushanda zvakanaka," iwe unogona kukwanisa kudana kune plumber. Iyo plumber inogona kuuya kumba kwako uye inogona kugadzirisa faucet inoputika kana kuibvisa zvachose kumisa mvura yakanyarara.
Kana iwe usingakwanisi kuita foni (yakaenzana neipi yakashata p53 geni), plumber haingadanwi uye kuputika kwaizoenderera mberi (kufanana nekenza masero akaparadzanisa), uye pakupedzisira mafashamo mumba mako.
Mune mamwe mazwi, p53 gene inoshandisa senzira yekuchengeteka inodzivirira masero asina kukwana kubva pakuva matumire munzira nhatu dzinokosha (sekare - kune zvakawanda zvatinofanira kudzidza pamusoro pe p53.) Ne:
- Kugadzirisa zvinokanganisa muDNA vasati vakuvadzwa masero ekuparadzanisa (uye kupfuurira pane kukanganisa.)
- Zvinokonzera apoptosis. Apo kukanganisa kwakaitwa DNA kwakazara zvakanyanya kuti kugadziriswe, zvipembenene zvinopesana nejeri zvakakonzera shanduro yakagadzirirwa kufa (apoptosis) kuitira kuti mhirizhonga isati yapfuura.
- P53 inogona kunge ine mamwe mabasa akawanda, kusanganisira zvinokonzerwa nemasabolism anoita basa rinokosha mukukura kwekenza.
Chii Chinokonzera Kuparadza kusvika kuP53 Gene?
Iyo p53 geni inogona kukuvadzwa (yakashandurwa) nezvinhu zvinokonzera kenza mumamiriro ezvinhu , zvakadai seutsi hwefodya . Inogonawo kunge isipo kune vamwe vanhu kubva pakuberekwa. Vanhu vanogara nhaka imwe chete yep53 gene (Li-Fraumeni syndrome) inotanga kuve nekenza yemakore gare gare muupenyu.
Kukosha kwep53 Gene muLung Cancer
Kunzwisiswa kwep53 geni uye mapuroteni ayo anorayira zvinogona kutungamirira nzira dzakanakisisa dzekuongorora nekurapa kenza yemapapu mune ramangwana.
Sources:
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Farnebo, M. et al. Iyo p53 tumor supprossor: tenzi wevatongi vemarudzi akasiyana-siyana emagetsi uye chinangwa chekurapa mukenza. Biochemical uye Biophysical Research Communications . 2010. 396 (1): 85-9.
Hecht. S. Kufambira mberi nematambudziko munzvimbo dzakasarudzwa dzefodya carcinogenesis. Kemikari Research in Toxicology . 2008. 21 (1): 160-71.
Vanyoro, D. Mutemo wemhinduro yep53 uye ukama hwayo nekenza. Biochemical Journal . 2015. 469 (3): 325-46.
Muller, P., uye K. Youden. p53 kuchinja kwekenza. Nzvimbo Yemajeri Biology . 2013. 15 (1): 2-8
Pfeifer, G. na A. Besaratinia. Kuonekwa kwekenza yekenza yevanhu. Human Genetics . 2009. 125 (5-6): 493-506.
Wang, X., Simpson, E., naK. Brown. p53: Kudzivirirwa kurwisana neHumora Kuwedzera kunze kweMigumisiro yeChikoro neApoptosis. Cancer Research . 2015 Nhamba 16. (Epub mberi kwekudhinda).