Chii chatinoziva pamusoro pekubatana pakati pe lupus uye lymphoma? Zvakanaka, isu tinoziva zvakawanda kupfuura zvatakaita makore makumi maviri adarika, asi mhinduro inogona kunge isiri "yakakwana," maererano nehurukuro yaBoddu nevakashanda navo vakaparidzirwa paIndaneti munyaya yaMarch 2017 ye "Case Reports in Rheumatology."
Lupus, kana Systemic Lupus Erythematosus (SLE)
Lupus , kana systemic lupus erythematosus (SLE), chirwere chakaoma kwazvo chinogadziriswa chinogona kuitika nhamba ipi zvayo yezviratidzo zvakasiyana zvakasiyana uye inogona kusanganisira zvirongwa zvakawanda zvemuviri mukati memuviri.
Chero ani zvake vanhu vaviri vane lupus vanogona kuva nezviratidzo zvakasiyana zvachose, asi apa pane zvimwe zvakajairika:
- Kurwadziwa pamwe chete, kuoma uye kurira
- Kuneta uye fever
- Kurwisana kwechiso pamatama uye bhiriji yemhino, zvinonzi kuva mavhiribvu, akafanana nemhuno semuviri nematama semapapiro eflyfly. Iko rinogona kunge rakaoma, rinogona kuva rakanaka, kana kupisa.
- Zvimwe zvinetso zveganda zvinoita sokuti zvinowedzera kukura kwezuva
- Zvigunwe uye zvigunwe zvinoratidzika zvichirasikirwa nekuparadzirwa, zvichiita chena kana bhuruu muchitonhora kana munguva dzinonetsa-iyi inonzi Raynaud's phenomenon
- Zviratidzo kubva kune zvakasiyana-siyana masangano; kupfupika kwefema, kurwadziwa kwepfupa, meso akaoma
- Kusurukwa musoro, kuvhiringidzika, uye kurasikirwa mupfungwa
Lymphoma, Cancer ye White Blood Cells
Lymphoma ndiyo kenza yemasero machena eropa, kunyanya masero echena machena anonzi lymphocytes . Izvo zvikamu zviviri zvinokosha zve lymphoma ndiHodgkin lymphoma uye isiri Hodgkin lymphoma , kana NHL. Lymphoma inowanzotanga mune lymph nodes, asi inogonawo kusanganisira nhengo dzakasiyana-siyana, uye inogona kubuda mukati mezvisikwa zvakasiyana-siyana uye zvivakwa zvemuviri, kwete chete lymph nodes.
Sezvo ne lupus, zviratidzo zve lymphoma zvakasiyana uye vanhu vakasiyana vane zviratidzo zvakasiyana-siyana zve lymphoma. Dzimwe nguva, chiratidzo bedzi ndicho lymph node inoputira:
- Uturu husina kuvhara kwemakumbo emakumbo ako mumutsipa, masimba, kana kugomera
- Kuneta uye fever
- Kuchengeta usiku kunopika
- Kurasika kwechido, kusatsanangurwa kwekureruka-kuwanda kwe10 muzana kana kupfuura kuwanda kwomuviri wako
- Ganda rinopisa
- Kusuruvara kana kurwadziwa kwepfupa, kurwadziwa kwepamuviri kana kuzara, mashizha, uye ganda rinoputika
Ndezvipi Izvi Zvimwe Zviitiko Zvakafanana?
Zvakanaka, dzimwe nguva zviratidzo zvinogona kuwirirana, kune imwe. Uye zvirwere zvose izvi zvinosanganisira maitiro ezvirwere zvezvirwere zvezvirwere: Lymphocytes ndiwo masero anokosha mumuviri wechirwere chemuviri, uye maitiro ezvirwere zvezvirwere zvezvirwere zvezvirwere zvinonzi awry muSLE. Lymphocytes zvakare ndiwo masvikiro anokonzera mu lymphoma.
Asi panewo zvakare: tsvakurudzo dzakawanda dzakawana kuti vanhu vane SLE vane chikwata chepamusoro che lymphoma kana vachienzaniswa nevanhu vose. Imwe yezvinyorwa zvakawanda ndeyokuti, muzvirwere zvemuviri zvisingagoni kurongeka (sekune mumwe munhu ane SLE), kushandiswa kwema immunosuppressive therapy kuporesa lupus kunogona kukonzera kuwedzera kwechiitiko che lymphoma muSLE. Zvisinei, zvidzidzo zvakawanda zvakaitwa panyaya iyi, uye zvinopesana nezvakawanikwa, uye izvozvo hazviiti seyiyo nyaya yose.
Boddu nevamwe vashandi vachangobva kuunganidza mamwe maitiro kubva pakuongorora kwavo kwechirongwa chekurapa kuti vawane ruzivo pamusoro pevanhu vane SLE vanovandudza lymphoma. Zvinokonzerwa nehutachiona hwekusimudzira lymphoma kuvanhu vane SLE hazvisi zvachose zvakajeka. Vanhu vane zvirwere zveSLE zvakaoma kana kuti zvinotyisa zvakaonekwa kunge vari pangozi ye lymphoma, uye imwe njodzi inonzi yakabatanidzwa kuti inobatanidza nekushandiswa kwe cyclophosphamide uye kuwedzera kwekuwedzera kune steroid.
Kunyange dzimwe nguva pakanga pane zvidzidzo zvishomanana zvokutora-uye kazhinji nhamba yevanhu vane SLE uye lymphoma vakange vashoma mune zvidzidzo izvi-Boddu nevatsvakurudzi vakashandisa zvavaigona kuwana pakuvaka chivako chekutanga chekudzidza. Zvimwe zvinotyisa zvinongororwa kubva kuongororo nevarwere veSLE vakagadzira lymphoma kutevera.
Vanhu vane SLE vakagadzira lymphoma:
- Vazhinji vaiva vakadzi
- Zera remakore rakange riri pakati pemakore 57 nemakore 61
- Paavhareji, vangave vaine SLE kwemakore gumi nemasere vasati vaita lymphoma
- Dambudziko reLymphoma kune vanhu vane SLE raive rakakwirira kudarika marudzi ose
- Zviratidzo, tsvakurudzo uye mabhii ekuongorora kwekutanga-staged lymphoma zvakaputika zvishoma nezvinoonekwa muSLE.
- Lymph node kuvhara, dzimwe nguva chiratidzo choga che lymphoma, chinowanikwawo kune vanhu vane SLE, inowanikwa kusvika 67 kubva muzana.
Lymphomas inokura muvanhu vane SLE:
- NHL yakawanda inowanikwa kune vanhu vane SLE yakaparadzanisa B-cell lymphoma (DLBCL) yakakura, iyo ndiyo inonyanyozivikanwa neNHL muvanhu vakawanda.
- I-subtypes yeDLBCL kune avo vane SLE yakaratidzika kakawanda mune imwe nhengo inowedzera kutengesa-iyo isiri yembeu B-cell-like DLBCLs.
- NHL muSLE, kufanana neNHL muhuwandu hwevanhu vazhinji, kazhinji inotanga mumakirini emakirini, asi mishonga inotanga kubuda panze emakirini anowanikwawo kune vanhu vakawanda uye kune avo vane SLE.
Vanhu vane SLE vanowanzobatwa ne glucocorticoids, voga kana kubatanidzwa nedzimwe mishonga inofungidzirwa kana inonzi cytotoxic kusanganisira methotrexate, cyclophosphamide, uye azathioprin kuti vabate urongwa hwekuita kana zviratidzo zvisingagadziri kurapwa pakutanga kushandiswa. Ongororo dzakawanda dzakaedza kuziva kana immunosuppressive agents anowedzera ngozi ye lymphoma kune vanhu vane SLE, asi kazhinji zvikamu zvekudzidza kumwe zvinopesana neiyo inotevera.
Pane mazano akawanda pamusoro pekuti sei vanhu vane SLE vangave vari pangozi yekenza mune zvekare, uyewo lymphoma kunyanya:
- Imwe yedzidziso yakadaro inosanganisira kupera kusingaperi. DLBCL inobva ku-activated lymphocytes ndiyo inonyanyozivikanwa neNHL subtype inosvika muSLE, saka pfungwa ndeyekuti kupora kusingaperi kunogona kukwidziridza ngozi ye lymphoma muzvirwere zvinotapukira seSLE.
- Imwe nyanzvi yakafanana asi ine zvakawanda zvemazwi. Mhedziso ndeyokuti autoimmunity ye SLE inotorazve maitiro ezvirwere zvemuviri kuti iite lymphocytes, masero e-lymphoma, kuparadzanisa uye kupararira.
- Chimwezve chirevo chinosanganisira Epstein-Bar, kana EBV. Uyu ndiwo hutachiona hunokonzera kutapukisa mononucleosis, kana mono, chirwere chinotsvoda. Mhedziso ndeyokuti zvichida chirwere cheEBV chinoramba chiripo, icho chinoramba chichiwedzera kuwedzera masimba ezvirwere mumuviri nenzira dzakarurama, chikamu chenzira yakajairika yezvirwere zveSLE uye B-cell lymphomas.
SLE, Lymphoma, uye Mimwe Kanza
Ikoko kunoratidzika kuva nehuwandu hwehuwandu hweHodgkin uye kwete-Hodgkin lymphoma kuvanhu vane SLE. Maererano nedhesi rakabudiswa muna 2015, pane sangano iri pakati peSLE nemarignancy, kwete kungoratidza NHL, Hodgkin lymphoma, leukemia, uye dzimwe dzisina ropa rekenza, asiwo kusanganisira laryngeal, mapapu, chiropa, vaginal / vulvar, uye utachiona hwemaperembudzi- uye pangangodaro kunewo mungozi yakaderedzwa yeganda remarara. Kansa yemazamu, mutsa wemapapu uye chirwere chemumuromo wechikenza, uye mutsara wekumetometrial yose inoratidzika kunge inotarisa neSLE yakawandisa pane zvingatarisirwa kune vanhu vakawanda.
Vanhu vane Sjögren's syndrome , iyo yakajairika kune vanhu vane SLE, inowanzova nengozi yakakura ye lymphoma, saka pane zvingave zvine chimwe chinhu chinopindirana nechirwere cheSLE chinosanganiswa nekusaura uye kunyanya lymphoma.
Kunyange zvazvo mamwe majekiseni ekuzivikanwa anoita seanochengeteka kune vanhu vane SLE kubva pane zvidzidzo zvakawanda, pane mazano ekuchengetedza mumabhuku-ezvokutanga CNS lymphoma (PCNSL) rudzi rushoma rweNHL runowanikwa munharaunda yepamusoro yenheyo kubatanidzwa pasina uchapupu ye lymphoma kune imwe nzvimbo mumuviri. Zvinenge zvose zviitiko zvePCSNL zvinoratidzwa nevanhu vane SLE zvinosanganiswa nemasikirwo emunosuppressive, uye mycophenolate kunyanya.
> Sources:
> Boddu P, Mohammed AS, Annem C, Sequeira W. SLE uye kwete-Hodgkin's lymphoma: nyaya dzenyaya uye kuongororwa kwemabhuku. Case Rep Rheumatol. 2017: 1658473.
> Cao L, Tong H, Xu G, et al. Systemic Lupus Erythematous uye Malignancy Dambudziko: A Meta-Analysis. Scheurer M, ed. PLoS ONE. 2015; 10 (4): e0122964.