Migumisiro Yechipfuva, Manyevero, Uye Mamwe Mashoko Akakosha
Simponi (golimumab) rudzi rwechirwere chinozivikanwa seN TNF-alpha ( tumor necrosis factor alpha ) blocker. Izvo zvakawanikwa kuti TNF inobatsira mukurudzirwa kwechirwere chechirwere chirwere (IBD). TNF inowanikwa mune zviyero zvakanyanya mumakoloni evanhu vane ulcerative colitis uye chirwere cheCrohn kupfuura kune vanhu vasina nzira ipi neipi yeBD.
Kungofanana nezvimwe zvirwere zvemuviri zvinoshandiswa kurapa IBD, zvinosunga kune TNF-alpha uye zvinodzivirira kubva pakushandiswa nemuviri. Ichi chirwere chinogadzirwa naJanssen Biotech.
Vatsvakurudzi vanofunga kuti TNF-alpha inobatanidzwa muBD uye maitiro emimba. IBD chirwere chekuvhiringidza, uye TNF-alpha inonzi chemicals messenger inozivikanwa se cytokine . Cytokines haisi kungotumira "mharidzo" pakati pemasero ari mumuviri, asi inobatsirawo pakusimudzira kupisa.
Zvinoshandiswa sei zviri nyore?
Simponi inopiwa sejisi pasi peganda. Mushure mekunge vadzidziswa nehutano hwehutano, varwere vanogona kuzvipa injenji yeCononi kumba. Ijojo idzi dzichauya nemashoko akajeka pamusoro pekushandisa kwavo, uye kugadza chiremba kuchapa chero imwe mirayiridzo inokosha iyo varwere vanofanira kutevera. Kutanga Kutanga, kune injini 2 kutanga. Zvadaro, jisi 1 inopiwa mavhiki maviri gare gare.
Uyezve, nokuda kwekuchengetedza, chirwere chinonzi Simponi chinopiwa mavhiki mana.
Zvishandiso
Simponi inogamuchirwa kuti iite zvisinganzwisisiki kune mishonga yakawanda (haisati yashandiswa seyokutanga yemishonga yemamiriro ezvinhu). Simponi inobvumirwawo kubata rheumatoid arthritis , psoriatic arthritis, uye ankylosing spondylitis.
Zvinongobatsira kuchengetedza kuputika nekubatana kune TNF-alpha. Kana TNF-alpha isisipo kuwanika kukonzera, IBD inogona kupinda nguva yekuregererwa (kana chirwere chezvirwere uye zviratidzo zvinoderera).
Ndiani Asingafaniri Kutora Simponi?
Taurira chiremba wako kana uri kurapwa nokuda kwehutachiona, kana iwe uri mutakuri wehutachiona hweH hepatitis B, uchangobva kuwana chirwere chinorarama, kana kuti wakambotarisana neAngoni.
Migumisiro Yechiri
Migumisiro inowanzovhiringidza yeAngoni inosanganisira kuputika kwepamusoro kwehutachiona, injection site reaction (zvakadai sekutsvaira kana kuzvimba), uye zvirwere zvehutachiona zvakadai sefivha uye zvironda zvinotonhora . Udza chiremba wako kana kune zvimwe zvinokonzera kushungurudza kana kusaenda. Iyi migumisiro yemigumisiro inofanira kuudzwa kunechiremba wako pakarepo.
Dzimwe Manyevero Pamagumisiro Akaipa
Zvimwe zvinoshandiswa uye zvinodhaka zveTFF-blocker zvakabatanidzwa nemamwe marudzi ehutachiona, kusanganisira tuberculosis. Chero kusvibiswa kune munhu ane TB inofanira kuziviswa kune anorayira chiremba. Varwere vanorapwa neCononi vanofanira kuongororwa nechirwere chetachiona (kusanganisira chimiro chakaipa chechirwere), uye vanorapwa kana zvichidiwa. Paanenge achitora ichi chirwere, varwere vanofanirawo kuongororwa nokuda kwezviratidzo kana zviratidzo zvechirwere chetachiona, zvakadai se:
- Chipfuva chepfu
- Kukosora
- Fever
- Kufirwa kwechido
- Night sweats
- Kuonda
Mamwe maitiro ehutachiona anokwanisawo, sezvo mishonga iyi inoderedza kusagadzikana kwomuviri kune zvinopararira. Varwere vanoenda kune imwe nzvimbo vane huwandu hwakawanda hwehutachiona hwehutachiona kana vane vane hutachiwana hwezvino vanofanira kurondedzera mamiriro aya kune chiremba anotsanangura Simponi.
TNF blockers vave vachibatanidzwa nekuvandudzika kwemamwe marudzi ekenza. Lymphoma yakambotaurwa kune vanhu vanotora TNF blockers. Kunyanya, njodzi yekukura hepatosplenic T-cell lymphoma inowedzera, kunyanya mumajaya.
Simponi yave ichibatanidzwa nekukura kwekenza yeganda . Vanhu vanotora Simponi vanofanira kuziva nezvekuchinja kupi kweganda ravo, zvakadai sekukura kwitsva kana makomesi anoshandura muvara kana maitiro.
Vanhu vane hutachiona hwehutachiona hweH hepatitis B vari pangozi yekugadziriswa kwehutachiona pavanotora mishonga inorwisa-TNF. Varwere vanotora Simponi vanofanira kuongororwa nehepatitis B uye vanofanirawo kungwarira zviratidzo nezviratidzo zvehepatitis B zvakadai se:
- Chills
- Mavara ane mavara-mavara
- Urine yakasviba
- Kunyanya kuneta
- Fever
- Kusava nenzara
- Muscle aches
- Ganda rinoputika
- Dumbu rakashata
- Kudzora
- Ganda rejena kana maziso
Nhamba yepamusoro yeropa yakave ichionekwa kune vamwe varwere vanotora anti-TNF zvinodhaka. Izvi zvinonyanya kukoshesa vanhu vane IBD, avo vari kutova pangozi yepamusoro masero emasero matsvuku eropa. Chiremba wako achacherechedza ropa rako nguva dzose kuti aone anemia .
Zvimwe zvinetso zvinogona kuitika pazvinenge zvichirwisana ne-TNF therapy zvinosanganisira mwoyo kusagadzikana, multiple sclerosis, Guillain-Barré syndrome, chirwere chechiropa, psoriasis, uye zviratidzo zvemapus.
Zvokudya uye Kubatana Kwezvinodhaka
Simponi inowanzobatwa pamwe chete nedzimwe mishonga inoshandiswa kurapa IBD dzakadai se corticosteroids. Mishonga inogona kuwirirana neCononi inosanganisira:
- Kineret (anakinra)
- Orencia (abatacept)
- Rituxan (rituximab)
- Urarame zvirwere
Hakuchina kushamwaridzana kwekudya kunozivikanwa.
Kudzivirirwa Panguva yekuzvimba
Iyo FDA yakarongedza Simponi sechirongwa cheB B. Mhedziso iyo Simponi ine mwana asati aberekwa haana kumbobvunzwa zvakanyanya. Simponi inofanira kungoshandiswa panguva yekuzvitakura kana zvakajeka. Zivisai kunyora chiremba kana iwe ukava nepamuviri paunotora Simponi. Hazvizivikanwe kana Simponi inopinda mumukaka wamazamu, zvisinei zvimwe zvinhu zvakafanana zvakaratidzwa kuti zvipinde mumukaka wemvere. Izvo zvinogona kukanganisa migumisiro yakakomba mucheche inofanira kuyerwa nekubatsira kwemishonga kuna amai. Imwe nzira ndeyekubvisa kunyamwa asati agadza Simponi.
Sources:
Janssen Biotech, Inc. May 2013.
Janssen Biotech, Inc. "Simponi Website." May 2013.
Olsen T, Goll R, Cui G, et al. "Tissue levels of tumor necrosis factor-alpha correlates nechikwata chekuvhiringidzika musina kuraswa kwehutachi." Scand J Gastroenterol . 2007 Nov 42: 1312-1320.
Roberts-Thomson IC, Fon J, Uylaki W, Cummins AG, Barry S. "Mishonga, magyrokine uye kuputira chirwere chechirwere: chirwere chekliniki." Nyanzvi Rev Gastroenterol Hepatol . 2011 Dec; 5: 703-716. doi: 10.1586 / egh.11.74.