Mamwe maBD Mishonga Target TNF Mapuroteni Kuratidzira Kuputika
Tumor necrosis factor (TNF) rudzi rwemaprotheni anozivikanwa se cytokine inobudiswa nemasero machena eropa . TNF inokosha mumuviri nekuti inobatsira kutonga mhinduro yezvirwere zvemuviri kune chimwe chinhu, kunze kwechirwere chinokonzera kenza. Inokurudzira kuvhiringidza, inobereka mamwe masero anoshandiswa mumhinduro yekuvhiringidza, uye inogona kubatsira masero kuporesa.
TNF inowanzonziwo se tumor necrosis factor-alpha.
Nei TNF-alpha inokosha muBD
TNF inyaya inokosha yekurapa zvirwere zvinoputika (IBD). TNF inowanikwa muhuwandu hwakawanda kune vanhu vane chirwere cheCrohn kupfuura vanhu vasina Crohn's disease. TNF inowanikwawo, kusvika pane zvishoma, muchigaro chevanhu vane ulcerative colitis. Nemhaka yekushamwaridzana uku, zvinofungidzirwa kuti TNF inobatanidzwa mukugadzirisa uye / kana kuenderera mberi kwechirwere cha Crohn uye chironda chekuonda. Ichi ndicho chikonzero zvinodhaka zvinonzi biologics zvakagadzirwa kuti zvirape IBD nezvimwe zvinhu zvinopesana. Kutarisa TNF kunobatsira kune vamwe varwere mukuderedza zviratidzo zveBD uye pakuporesa kuputika mumatumbo emukati.
Fecal calprotectin uye lactoferrin zvikwangwani zviviri zvinoshandiswa kuongorora kupisa kwezvino kune vanhu vane IBD. Aya mapuroteni maviri anogona kuyerwa nokuedza chigaro.
Zvakawanikwa kuti kana pane zvakawanda zvepuroteni iri muzvigaro, pane kuvhiringidzwa kwakanyanya mumatumbo evanhu vane IBD. Apo zviyero zvepuroteni idzi zviri pasi muzvigaro, pangave nekuporeswa kuitika mumatumbo. A lower fecal calprotectin uye lactoferrin zvingareva kuti kurapa kuri kushanda uye kuti murwere ari kuswedera, kana ari mukuregererwa.
Zvidzidzo zvakaratidza kuti fecal calprotectin uye mazinga e-lactoferrin ari pasi kune varwere vakatora anti-TNF mishonga.
Mhando dzakasiyana dzeNATF
Genetic studies yakaratidza kuti pane marudzi akasiyana eTNF, uye TNF inowanzoonekwa se "superfamily." Mhando dzakasiyana dzeNATF dzave dzichibatanidzwa nezvimwe zvirwere zvega autoimmune, kenza, uye chirwere cheshuga. Kuwana mhando dzeTNN-dzinosangana nemamiriro ezvinhu chaiwo zvinogona kubatsira mukudzikisa mishonga yekurapa zvirwere izvozvo.
Haasi munhu wose ane IBD anopindura mishonga imwechete nenzira imwecheteyo. Izvi zvinogona kunge zviri, uye iye zvino zvinofungidzirwa kuti ndeyezvakaitwa neyanzvi, kuti pane dzakawanda subtypes dzeBD. TNF inogona kuitawo izvi mune izvi zvakare, nokuti vamwe vanhu vane IBD vanopindura zvakanaka chaizvo kupikisa anti-TNF zvinodhaka zvinodhaka, asi vamwe vanhu havaiti. Ijenotype yeTENF yeumwe murwere inogona kubatanidzwa nekupindurwa kukuru kana kuduku kune imwe mishonga inorwisa anti-TNF. Iyi inzvimbo inowedzera yekutsvakurudza, uye kune zvimwe zvakawanda zvakawanda zvinonzwisiswa maererano neTNF zvisati zvingashandiswa kumutano wevarwere.
TNF-alpha In Colon Cancer
TNF inogonawo kuva nebasa rinokosha rinovaka kenza yekoloni nemamwe makondombera emakumbo. Kutsvakurudza mune izvi zvinoitika zveNATF zvisati zvisingatauriki, asi zvinogona kupawo mamwe mazano mukati mekubatana kwechirwere chetermatitis uye kenza yemukironi.
Anti-TNF-alpha Mishonga
Zvimwe kurapwa kwechirwere cheCrohn's disease zvinosanganisira kutarisa puroteni yeN TNF uye kuisunga iyo. Apo puroteni yakasungwa saizvozvo, haikwanisi kubudisa kupisa. Zvimwe zvinorwisa-TNF zvinodhaka Remicade (infliximab), Humira (adalimumab), Cimzia (certolizumab pegol), Enbrel (etanercept), uye Simponi (golimumab).
Tsananguro Inobva
Pane zvakawanda zvisingazwisisi maererano neTNF uye ukama hwayo nemamiriro ekuvhiringidza akaita seBDD. Zvisinei, mishonga yakawanda inorwisa-TNF yakagadzirwa kuti ishandiswe kune vanhu vane IBD, uye inogona kunge yakagadzirisa migumisiro yenguva yezvirwere izvi.
> Sources:
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> Subramaniam K, Richardson A, Dodd J, et al. "Kufanorongedza kwekutanga kwe colectomy nekuchengetedza kwenguva refu kwekuregererwa mu ulcerative colitis varwere vakabata kushandisa anti-tumor necrosis factor therapy." Intern Med J. 2014 May; 44: 464-470. doi: 10.1111 / imj.12397.
> Taylor KD, Plevy SE, Yang H, et al. "Nhengo yeANCA neLTA haplotype ukama kune zvipatara zvinopindurwa kune anti-TNF antibody inorwara muCrohn's disease." Gastroenterology . 2001 May; 120: 1347-1355.
> Yang JP, Hyun MH, Yoon JM, et al. "Kushamwaridzana pakati peNATF-α-308 G / A maitiro emapirymorphism uye chirwere chepabonde chepamusoro: chiitiko chekuongorora nekuongorora meta." Cytokine . 2014 Dec; 70: 104-114. doi: 10.1016 / j.cyto.2014.07.005.