Kwete Kazhinji Nezvokuvhiringidza Mamiriro
Platelets shomanana dzinotenderera zvidimbu zvemasero zvinoita basa rinokosha mu hemostasis (nzira yekumira ropa shure kwekukuvara). Havana kamu asi asi ine cytoplasm uye mapuroteni anokosha nokuda kweplatelet function. Platelets inogadzirwa ne megakaryocytes mumufupa.
Platelets inowanzokwidziridzwa mune rheumatoid arthritis .
Mamiriro epamusoro maplatelets anozivikanwa se thrombocytosis.
Mu rheumatoid arthritis, manotsi ndiwo nzvimbo yekutanga yekukuvara. Ikoko ndiko kuputika kwemukati kunoitika, kusanganisira masero eropa anosanganisira neutrophils uye macrophages. Izvo masero anowedzerawo kugadzirwa kweplatelet-activating factor, iyo inokonzera kuunganidzwa kweplatelet yeopa, zvichiita kuti vabatanidzwe mukuputira kwemuviri mumuviri.
Platelets muRheumatoid Arthritis
Vanhu vane hutano vane platelet inowanikwa mumakero akaenzana e 150,000-400,000 / mm3. Kubvira kare kare muna 1972, yakaonekwa mumabhuku ekurapa ayo vatsvakurudzi vakawana mapeletti akakwirira akaenzana mune imwe yechitatu ye rhumumidhi varthritis varwere.
Izvi zvakawanikwa zvichibatana zvakananga nehutano hwemabasa. Vatsvakurudzi vakawanawo kuwirirana pakati pepamusoro peplatelet count uye anemia , leukocytosis (kuwedzera kwenhamba yemasero machena), uye rheumatoid factor .
Pane hukama hwepakati pakati pe hemoglobin uye platelet count, zvinoreva, apo hemoglobin iri pasi, platelet yakawanda yakareba. Kushamwaridzana kwekideropenia (kuperevedza kwesimbi) uye platelet kuverenga kukwirira kwakanga kusina kuonekwa sekukosha.
Vamwe vanhu vane rheumatoid arthritis yakawanda vanogona kunge vane platelet inopfuura mamiriyoni.
Kana chirwere chacho chichiiswa pasi peshandiswa nemishonga, platelet count inowanzodzokera kune yakajairika.
Platelets inokurudzirwa kwete muurheumatoid arthritis chete, asiwo mune zvimwe zviitiko zvinopesana. Chibvumirano chakakosha chakawanikwa pakati pepamusoro maplatelet uye vasculitis echeka . Zvimwe zviratidzo zvisingaenzaniswi zverheumatoid arthritis (kureva, kuchinja zvikamu zvemuviri kunze kwezvikamu chete) zvakawanika kakawanda pakati pevanhu vakanga vakwira maplatelet kuverenga.
Zvinokonzera
Tsanangudzo yakanakisisa yepamusoro peplatelet inoratidzira mu rheumatoid arthritis inoratidzika yakabatana nechirwere chemazuva mashoma, chinowanzoonekwa cherheumatoid arthritis. Maererano neAnals of the Rheumatic Diseases , platelet homeostasis inodzorwa ne thrombopoietin.
Thrombopoietin ndiro guru rinotungamirira megakaryocyte kukura uye kusiyanisa. Inofungidzirwa kuti thrombopoietin inogona kunge yakabatana nemakemikari kune erythropoietin (hormone inobatanidza muropa tsvuku yekubudisa masero), zvikurukuru nokuti nguva dzose varwere vane chirwere chinonzi reticulocytosis (kukura kwenhamba yemasero matsvuku eropa) uye kuwedzera mazinga eerythropoietin ave akakwirira kudarika mapepa akawandisa eplatelet. Kana mazinga eerythropoietin akawedzerwa kune vanhu vane chirwere chekushaya ropa uye rheumatoid arthritis, kukwirira kweplatelet zvingaguma.
Imwe nzira inogona kuva iyo kana kuwedzerwa kweplatelet yakakonzerwa nekuwedzera kweplatelet kuparadzwa kana kushandiswa. Vatsvakurudzi vakatsanangurawo kuti hupamhi hweplatelet hunogona kunge huchibatanidzwa nehutachiona hwehutamuidhe rheumatoid arthritis-zvichida semugumisiro wemakumbo maduku mukati mezvirwere zvinonzi synovium .
Maererano neKelley's Textbook yeRheumatology , kune zvikonzero zvitatu zvakakonzerwa nepamusoro peplatelet kuwanda kwezvirwere zve rheumatic:
- Kuita zvepabonde thrombocytosis, yechipiri kune chirwere chisingaperi chine kupisa. Mumamiriro ezvinhu akadaro, ma cytokines (IL-1, IL-6, uye TNF) anogona kunge ari vanyori vanoita basa mukugadzirisa kweplatelet pakugadzira panguva yekuvhiringidza.
- Chirwere cheprombocytosis chinogona kuitika nekuda kwekuwana nhaka yemuviri.
- Clonal thrombocytosis (inonyanya kukosha kana kuti inokosha inonyanya kushandiswa) ndeyekusagadziriswa kusina kusarudzwa kwekugadzirwa kweplatelet nekuda kwekuchengetedzwa kwegagakaryocyte kupararira.
> Sources:
> Hutchinson RM et al. Thrombocytosis mu rheumatoid arthritis . Annals weRheumatic Diseases. (1976) 35: 138
> Kiraz S. et al. Bloodstream thrombopoietin mu rheumatoid arthritis ne thrombocytosis, Clinical Rheumatology. 2002 Nov; 21 (6): 453-6.
> Kelley's Textbook of Rheumatology. Ninth Edition. Chitsauko 17. Platelets uye Rheumatic Diseases. Mapeji 249-251.
> Thrombocytes muRheumatoid Arthritis. Scandinavia Journal of Rheumatology. Selroos, O. 1972 1: 136.