Iyi muedzo inoona autoantibodies iyo inobatsira kutsigira kuongororwa
Chirwere che anti-CCP chinoshandiswa kuongorora autoantibodies uye kubatsira kusiyanisa pakati pehu rumatoid arthritis nezvimwe zvinokonzera zvirwere zveArthritis . Iyo cyclic citrullinated peptide (CCP) antibody is autoantibody inopikisa mapuroteni anonzi citrullinated (ACPA) uye inotaridzwa nemuedzo uyu.
Chiyero chine uwandu hwepamusoro hwerheumatoid arthritis , inonzi inenge pakati pe50 ne75 muzana.
Iyo inewo zvakanyanya zvakanyanya kunyanya kuratidza rheumatoid arthritis inenge 90 muzana. Iyo yakanyatsojeka ndeyekuti nei kupikisa kwe-anti-CCP kwava chikamu chinokosha chekuongorora chirwere cherheumatoid arthritis.
Kuongorora kweAnti-CCP Kuongorora uye Prognostic Value
Kunze kwekubatsira kusiyanisa pakati pezvokuvhiringidza zvirwere zveArthritis , chirongwa che-anti-CCP chinonyanya kukosha pakuongorora vanhu vane seronegative nokuda kwerumatoid factor . Handizvo chete kuti kupikisa kweCCP kunoratidzei kukosha (kutarisa mamiriro api aunayo), iyo inewo chirevo chekufananidzira (kufanotaura zvedzidzo yemamiriro ako).
Kana zvinopesana neCCP zviripo pamwero wakaenzana kusvika kumusoro, hazvingobatsiri kusimbisa kuongororwa, zvinoratidza kuti panogona kunge iri inoparadza uye yakaoma chirwere chetachiona, zvakadai sekukuvara kwekubatana. Low level of the antibody is not as telling or predictive.
Kazhinji, chirongwa che-anti-CCP chinorayirwa pamwe chete nechirwere chemukoko chinokonzerwa nedheumatoid, sezvo kuongororwa hakuna chete kunogona kusimbisa kusimbiswa kwerheumatoid arthritis.
Maererano neRheumatologist Scott J. Zashin, "Kunyange zvazvo rheumatoid chinhu inowanzoonekwa kuvanhu vane rheumatoid arthritis, pane vanhu vane hutachiona hwehrumatoid iyo isina rheumatoid arthritis. Uyezve, kuvapo kwehramumidhi chinhu chisinganyanyi kukosha kupfuura ACPA.
Uyewo, kana munhu asina kunaka nokuda kwemukoko, haasati aita zvakanaka kune ACPA. "
Kuziva Autoantibodies
Kukosha kwekuona autoantibodies muzvirwere zverheumatic kwave kuchizivikanwa kwemaakumi emakore, asi kuziva izvo zvaive zvekliniki zvakakosha maererano nehuwandu hwehutano uye hwekunzwisisa zvakatora nguva. Pakave nezvizvarwa zvitatu zvemuedzo we anti-CCP. Nechizvarwa chimwe nechimwe chekuedza izvo zvakasikwa uye kushushikana zviri nani.
Maererano ne "Kelley's Textbook of Rheumatology," vanopfuura 90 muzana yevanhu vane chirwere chisingaverengeki chinonzi test anti-CCP vanoita rheumatoid arthritis mumakore matatu. Kunenge 25 kubva muzana yevaya vasina hutachiona husina hutachiona vanoedza kusagadzikana nehutachiona hweCCP kukurudzira rheumatoid arthritis.
Autoantibodies inogona kuonekwa pamberi pekurapwa kwechipatara kune zvimwe zvirwere zvinokonzerwa nemhuka, kusanganisira rheumatoid arthritis. Autoantibodies inogona kutangira kutanga kwechirwere chemahythritis arthritis nemakore maviri kusvika matanhatu, maererano ne "Kelley's Textbook yeRheumatology." Zvinonzi, inogona kupikiswa anti-CCP inotangira kuongororwa kwerheumatoid arthritis inowanikwa kaviri yakawanda sezvinoonekwa nehurumatoid factor inotangira kuongororwa.
Kunyange zvazvo rheumatoid chinowanzogara chiripo nguva dzose, kuvapo kwe-anti-CCP kunogona kusiyanisa muhurongwa hwehutatoid arthritis-kunyange kunyangarika pane dzimwe nguva.
Kukosha kweAnti-CCP
Vatsvakurudzi vanoenderera mberi kutarisa zviri kuitika mumuviri kuti zvive nemamolekoro (antigens) anokonzera kugadzirwa kwezvirwere izvi zvinopesana neCCP. Ivo vanonzi autoantigens nokuti vanobudiswa nekuparara kwezvinhu mukati memuviri panzvimbo pokubva kunze kwomuviri. Peptidylarginine deiminase (PAD) enzymes, iyo inobatsira kutendeuka kwe peptidylarginine ku peptidylcitrulline, ine basa rinokosha pakuita autoantigens mu rheumatoid arthritis.
Uyewo, kutsvakurudza kwakawanda kunodiwa kuti uone kuti chii chinokonzera chiitiko chekutanga chechirwere cherheumatoid arthritis kuti chiende mune zviratidzo, zvirwere zvakakwana.
Kunyange zvazvo anti-CCP yakanyanya kunyatsojekesa rheumatoid arthritis, zvibereko zvakanaka zvinogona kuitika nedzimwe zvirwere zvinoshandiswa nehurmumune rheumatic, chifukidzo chechirwere, uye chirwere chisingaperi chemapapu. Anti-CCP ma antibodies ave achitsanangurwa mu systemic lupus erythematosus uye sjogren's primary syndrome , kazhinji apo inorwisa arthritis iripo. Ive yakawanikwa zvakare kusvika ku16 kubva muzana yevanhu vane psoriatic arthritis -kazhinji kazhinji neyero or polyarthritis . Dzimwe nguva, inofambisa zvakanyanya psoriasis pasina arthritis.
> Sources:
> Cush JJ, Kavanaugh A, Weinblatt ME. Rheumatoid Arthritis: Kuziva Kukura Kwekare uye Kuporesa . West Islip, NY: Professional Communications; 2010.
> Firestein GS, Kelley WN. Kelleys Textbook of Rheumatology . Philadelphia, PA: Elsevier / Saunders; 2013.
> Taylor PC, Maine RN. Biologic Markers muKutsvaga uye Kuongorora kweRheumatoid Arthritis. Kusvika pari zvino. https://www.uptodate.com/contents/biologic-markers-in-the-diagnosis-and-assessment-of-rheumatoid-arthritis.