Nzira Inobatsira Yevarume neVasikana vane HIV
Kushaya kusimba kwe testosterone kunowanzoonekwa kune varume nevakadzi vane HIV . Endocrine isina kukanganisa, iyo inogona kukanganisa maitiro ekutonga, yakave ichizivikanwa sechinhu chinokonzerwa neHIV kubva pamazuva ekutanga epachirwere (kunyange zvazvo kazhinji ichibatanidzwa nechekupedzisira chirwere).
Zvisinei, kutsvakurudza kwemazuva ano kwakaratidza kuti inenge imwe yevarume vashanu vese vane HIV yakaratidza kupererwa kwe testosterone, pasinei neCD4 count , utachiona hwehutachiwana , kana hutano hwehutano.
Saizvozvowo, kushaya simba kwe testosterone kunowanikwa mune rimwe revakadzi vana vane HIV, kazhinji mumamiriro ezvinhu akaoma, kusatsanangurwa kwekurema kwehutachiona ( HIV kuparara ).
Basa reTesttosterone
Testosterone ndiyo hormone inonzi steroid iyo inonyanya kukwidziridzwa kwee testes (testicles) uye prostate mumarume pamwe nekusimudzirwa kwechipiri chechikadzi zvehupombwe (semuenzaniso, hutema hutema, bone mashoma, kukura kwemvere). Testosterone inokoshawo kuvakadzi mukuchengetedza musimba uye musasa mashoma, kunyange paanenge ari madiki anenge 10% pasi pevarume.
Muvarume nevakadzi, testosterone inokosha kumunhu wese hutano hwakanaka uye hupenyu hwake, zvichipa simba romumwe munhu, mazinga emvura, uye libido.
Kusiyana neizvi, testosterone depletion inosanganiswa ne:
- Kurasikirwa kwemaonda musimba
- Anemia
- Osteoporosis
- Insulin kushorwa
- Kuwedzera lipids (mafuta uye / kana cholesterol) muropa
- Kuwedzerwa mafuta pasi mucheche
Testosterone Deficiency
Kutadza kwaTesttosterone muvarume vane HIV kunonyanya kusanganiswa nekusingaperi kwechigunokita kunonzi murume hypogonadism umo basa revarume gonads (testes) risina kunaka, zvichiita kuti kuderedzwa kwemahomoni ezvepabonde kuderedze kupfuura izvo zvingatarisirwa panguva yevanhu.
Muhuwandu hwevanhu, hypogonadism inozivikanwa kuti inowanikwa mune imwe chete pakati pevarume makumi maviri nemashanu pakati pemakore makumi matatu nemakumi mashanu, zvichiwedzera kune imwe mu14 kubva pakati pemakore 50 kusvika kune 79. Kusiyana neizvi, chiitiko pakati pevarume vane HIV chakafanana kanomwe hukuru.
Kunyengedza kunogona kukonzerwa nechiremara mu testes ivo (primary) kana kushanda kunowanikwa kunze kwee testes (yechipiri). Muvanhu vakuru varume vane HIV:
- Primary hypogonadism inokwana makumi maviri nemakumi mashanu ematambudziko. Inogona kukonzerwa nekukuvadza kune ma testes nekuda kwehutachiona (kusanganisira zvimwe zvirwere zvinokonzerwa nematambudziko), kenza yemupupuri , kana kuora mwoyo mumuviri we testes (kunyange kukanganisa kune imwe nyanzvi imwe chete hakurevi kubatanidza kuderedza kupera kwe testosterone).
- Secondary hypogonadism inowedzera kune dzimwe 75%, uye inowanzowanzobatana nekusawirirana neuroendocrine umo kushamwaridzana pakati penheyo ye system ne endocrine system haina kukwana. Kunyange zvazvo pane zviitiko zvisingawaniki zveHIV zvichikonzera kuparadza kune chirwere chepituitary, HIV pachayo haina kukonzera kuora mwoyo. Pane kudaro, hypogonadism inowanikwa mukuvapo kwezvirwere zvakawanda zvisingaperi, nekuputira kusingagumi uye kuperevedza kwekureruka kwemaoko kunoratidzika kunge kushamwaridzana nezvinhu.
Kunyengera kunogona kukonzerwa nehuduku hwemucheche kana kushungurudzwa kwevanabolic steroid. Mishonga yeHIV haina kuonekwa kuti inobatsira ku hypo hypoadism.
Zviratidzo zveMunhu Kuzvidzivirira
Kunyengera kwevarume vakuru kunoratidzwa nechepasi serum (ropa) mazinga e testosterone, pamwe chete nechimwe kana zvimwe zvinotevera zviratidzo:
- Tsvina inopera
- Kuderedza simba uye simba
- Kuora mwoyo, kusagadzikana, kunetseka kuisa pfungwa
- Kuwedzera kwezvipfuva zvemazamu (gynecomastia)
- Kupera kwebvudzi remuviri nemuviri
- Kuwedzera mumafuta emimba
- Kurasikirwa kwefupa (osteoporosis)
- Testicular shrinkage
- Kuipa kwepabonde (semuenzaniso erectile dysfunction, lower ejaculate, low libido, kunetseka kuwana orgasm)
Kuedzwa uye Kuongororwa
Kuongororwa kunoitwa nekuyera muwandu we testosterone muropa, iyo pane matatu katatu akasiyana. Kana muedzo uchiitwa, zvigumisiro zvinoratidza zvose testosterone yemunhu (ose subtypes) uye imwe yevatatu subtypes inonzi testosterone yakasununguka .
Testosterone yakasununguka inongova yerudzi rwe testosterone iyo isina puroteni yakabatanidzwa, ichibvumira kupinda masero uye kushandura receptors izvo mamwe subtypes asingagoni. Iyo inofungidzirwa kuti ndiyo yakarurama yakakwana ye testosterone inoshaya, pasinei nekumirira chete 2-3% yehuwandu hwevanhu. Pamusoro payo, testosterone yakazara inonzi yakarurama zvishoma sezvo mhinduro inogona kuonekwa yakasununguka kana dzimwe dzisiri dzisina mahara dzichikwidziridzwa.
Kuedza kunofanira kuitwa mangwanani-ngwanani sezvo maitiro anogona kuchinja kusvika kusvika 20% panguva yezuva. "Kazhinji" maitiro ndeaya avo vari mukati mechirongwa chebhuku rebazi. Aya mazera anogona kusiyana, asi, nenzira yekufananidzira, inenge iri pakati
- 250-800 ng / dL ye testosterone yose, uye
- 50-200 pg / mL ye testosterone yakasununguka.
Zvisinei, kuongororwa kwe "chimiro" hakugone kuitwa nenhamba chete. Mazinga eTesttosterone anowanzokanda neanenge 1-2% gore roga roga mushure mezera remakore makumi mana. Saka, chii chingava "chimiro" chemurume wemakore makumi matanhatu nemakore ane makore makumi maviri nemashanu. Miedzo inofanira kuitwa pamunhu mumwe nomumwe nechiremba wako kurapa.
Yakarongwa Kurapa
Kana kuongororwa kwei hypogonadism kunoratidzwa, testosterone replacement therapy ingaratidzwa. Majojo e testosterone emakumbo anowanzokurudzirwa, anopa miviri yakaipa kana miviri yepanyama inoshandiswa uye ichigadziriswa nachiremba wokurapa. Zvimwe zvinoshandiswa neDAA zvinosanganisira Depo-testosterone (testosterone cypionate) uye Delatestryl (testosterone enanthate).
Paavhareji, majekiseni anopiwa mavhiki maviri kusvika mana. Kuchengetedza migumisiro yekuchinja kwemasero e testosterone-izvo zvinogona kukonzera dzimwe nguva zvinoshamisa kuchinja mumanzwiro, simba, uye zvepabonde-maitiro mashoma uye nguva shomanana yekuwedza inowanzoshandiswa.
Zvimwe zvikamu zvehutano zvinogona kusanganisira:
- Acne uye / kana ganda rine mafuta
- Kusuruvara kwevhudzi kana kuponda kwebvudzi
- Kufugama kwetsoka, maziso kana muviri
- Kurara kuputika
- Kuvandudza mazamu emvere (gynecomastia)
- Ropa rinovhara
- Kuwedzera kwe prostate
Testosterone replacement therapy inogonawo kukonzera kuwedzerwa kwekenza yekare yekare yaivepo. Nemhaka yeizvi, murwere we prostate-specific antigen (PSA) achaongororwa uye anoongororwa panguva yekurapa.
Zvose zvinoudzwa, majekiseni emakumbo anopa mari inoshandiswa kushandiswa kwekutenda hypogonadism, pamwe nekuwedzera kushamwaridzana mukuchenjerera, hukama hwakanaka, libido, kuonda kwemisasa, uye kukwanisa kukwanisa. Kukanganisa kunosanganisira chiremba nguva dzose kushanyira uye dosing administration.
Mhedziso, kutenderera, uye majeeti emagetsi ejeri anowanikwawo, uye anogona kushanda mune dzimwe nguva. Kurukurai izvi nechiremba wenyu.
Kunyengera kweHIV-Vakanaka Vakadzi
Madzimai, testosterone inobudiswa mune maevari uye adrenal glands. Sezvakaita nevarume, iyo inokosha hormone yekuchengetedza musimba uye musana mashoma, uyewo simba, simba, uye libido.
Kunyange zvazvo hypogonadism isingazivikanwi zvikuru kuvakadzi vane HIV, inogona kuitika uye inowanzowanikwa mumamiriro ezvinhu eHIV kupera uye zvirwere zvakanyanya. Kushandiswa kweART kunogona kushandura kuparadza uye hypogonadal mamiriro mazhinji muzviitiko zvakawanda.
Parizvino haisi mitsara yakagadziriswa yekurapa kwehukadzi hypogonadism, uye zvisarudzo zvokurapa hazvigoneki. Hormone replacement therapy (HRT) inogona kunge yakakodzera kune vamwe, asi kushandiswa kwenguva pfupi kwe testosterone kunogona kuvandudza zvepabonde, kuonda kwemasumbu, uye masimba emagetsi.
Zvisinei, dheta haisati yakakwana mukushandiswa kwe testosterone kuporesa hypogonadism mune vakadzi vekare vanopedzisira vane HIV. Taura nemutarisiri wako wehutano pamusoro pemigumisiro yemigumisiro. Testosterone haina kukurudzirwa kune vakadzi vane pamuviri kana kuti vanoda kuva nemimba.
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