Mishonga yakawanda -kusanganisira mabhakitiriya, mavairusi (akadai se Epstein-Barr virus), uye zvipembenene - zvinosanganiswa ne lymphoma. Ichokwadi, inenge 18 muzana yematambudziko ekenza pasi pose inogona kuenzaniswa nemishonga, maererano nekufungidzira kumwe. Zvisinei, kutaridzirwa kune utachiona chete hakukwani kukonzera kuipa kwemaitiro akawanda. Pane zvimwe zvinhu zvakakosha muzvinhu zvinotamba, kusanganisira mazamu uye maonero akasiyana-siyana mumuviri wezvirwere mumuviri wezvirwere izvi.
EBV uye Lymphoma
Epstein-Barr virus (EBV), hutachiona hunokonzera kutapukisa mononucleosis , inokonzera vanhu vakawanda pasi rose. Ichokwadi, inopfuura 90 kubva muzana yehuwandu hwehuwandu hwevanhu pakupedzisira inotapukirwa neEBV, uye hutachiona hunoenderera mberi hupenyu hwose, kunyange zvazvo kuvapo kwayo kungave kusina basa kune vakawanda. Kuwanda kweEBV zvirwere muvana hazvina maturo kana kuti zvinokonzera zviratidzo zvisiri izvo, asi zvirwere zvinotanga kuitika munguva yekuyaruka zvingaguma nekutapukisa mononucleosis mu50 muzana yevarwere.
Chii chinoita kuti EBV yakasiyana kubva pakuona kwe lymphoma ndeyokuti ine yega yega yemagetsi inokonzera kukura kushandiswa kwemasero ayo inopinza. EBV inonyanya kukonzera B-seli (rudzi rwechichena chemuviri weropa). Kunyange zvazvo yakawanda nguva iyo hutachiona hunokonzera kukuvadza kwakanyanya, dzimwe nguva kukura-kuita maitiro eB-maseva kunogona kusanganiswa nekenza mune vamwe vanhu. Nokudaro, EBV inoonekwa sechinetso chekuda kwemamwe marudzi e-lymphoma.
Post-Kutunga Lymphoma neAIDS-Yakabatanidzwa Lymphoma
EBV yakanyatsobatana nekukudziridza lymphoma mushure mekunyora kwomuviri . Pashure pemhando ipi neipi yechirongwa chekugadziriswa , avo vanogamuchira kugadzirwa vanofanira kupiwa mishonga inodzivirira kupindirana kwezvirwere zvemasimba kune dzimwe nyika. Izvi zvinobvumira nhengo yakatemwa kuti idzivirire maitiro ekudzivirira zvirwere zvemuviri, asi madhiragi aya, zvinosuruvarisa, anogona kuderedza simba rekudzivirira muviri uye kuita kuti muviri uwane zvirwere zvakasiyana-siyana zvehutachiona, kusanganisira EBV.
Munguva yeAIDS zvakare, pane kurasikirwa kwekudzivirirwa kwezvirwere mumuviri. Mune mamwe mamiriro ezvinhu, mavairusi akaita seEBV anogona kukonzera kukura kusina kuenzana kweAIDS B-seli uye kubatsira kuvashandura kuva lymphomas.
Burkitt's Lymphoma uye Malaria
Burkitt lymphoma, kana BL, ndiyo inonyanya kuve isiri yeHodgkin lymphoma kuvana nevechiri kuyaruka pasi rose. Munzvimbo dzakawanda dzeAfrica, EBV yakabatana zvikuru neBurkitt's lymphoma . Kunyanya, kuva nehutachiona hweEBV hutachiona hunobatanidzwa nekuvandudzwa kweB BL. EBV inokonzera hutano husina kujeka hunobatsira kushandura B-masero kuva kenza. Kudzokorora hutachiona hwemarariya kunobatsira EBV kukonzera lymphomas.
Chirwere chacho chakatumidzwa zita raDkt Denis Burkitt, muIrish missionary, uye chiremba ainzi aishanda muAfrica. Burkitt uye vaaishanda navo vakawana BL muna 1957, apo maitirwo akabatanidzwa mumatunhu apo malaria yakanga iripo-iyo inonzi "lymphoma belt". Zvisinei, marariya chirwere chinoparadzanisa masero matsvuku eropa, kwete masero eropa machena e-lymphoma, saka saizvozvo chaiyo yakanga isina chakavanzika kwemakore makumi mashanu.
Muzhizha ra 2015, zvisinei, chimwe chiedza chakadururwa pamusoro pehurukuro yacho, kunyangwe mune zvidzidzo zvemhuka. Kushanda nemakonzo, vatsvakurudzi veRockefeller University vakatungamirirwa naMichel Nussenzweig vakawana kuti iyo enzyme inobatsira kuita zvirwere zvekurwisa marariya inokonzera kukanganisa kweDNA kunogona kutungamirira kuBurkitt's lymphoma.
Tsvakurudzo yakabudiswa muna August 2015 mumagazini "Cell."
Hodgkin's Lymphoma
Hodgkin's lymphoma , kana HL, ndeimwe rudzi rwe lymphoma inobatanidzwa neEBV. Munyika dzekumadokero, vanenge 40 muzana yevanhu vane HL vanewo utachiona neEBV. Utachiona hwehutachiona hungave hwuchiwedzerwa mune dzimwe nzvimbo dzakawanda dzenyika. Nzira chaiyo iyo EBV inogona kukonzera Hodgkin's lymphoma haina kunyatsonzwisiswa, asi zviri kuve pachena kuti EBV ine basa rinokosha rinofanira kuitwa mukuvandudzika kweiyi lymphoma. Kunyange zvingave zvakabatana nemhando dzakasiyana dzehutachiona hweHodgkin, inowanzosanganiswa yakavhenganiswa nemafuta, yakawanda yeHodgkin's lymphoma.
HL mumapoka ekukwegura uye muvana, kunyanya vakomana pasi pemakore gumi, yakaratidzwa kuti inowanzova EBV-inobatanidza neHL kune vechidiki vaduku.
EBV-positive Inoparadzanisa Makuru B-cell Lymphoma yeVakuru
Kunyange zvazvo kuparadzanisa B-cell lymphoma (DLBCL) yakakurumbira kwechinguva, EBV-positive DLBCL yevakwegura yakatanga kurondedzerwa muna 2003, uye inorongwa panguva imwechete muna 2008 World Health Organisation system - iyo inorondedzera se "EBV -iyo inokonzerwa ne-monoclonal yakakura B-cell kupararira inowanikwa nevarwere> makore makumi mashanu uye mavari pasina kuzivikanwa kwemuviri wemuviri kana nhoroondo ye lymphoma. "Kuipa uku kwakazara muAsia asiwo kunowanikwa muNorth America neEurope paine pfupi .
> Sources:
> Brady G, MacArthur GJ, Farrell PJ. Epstein-Barr HIV uye Burkitt lymphoma. Zvinyorwa zveKliniki Pathology. 2007; 60 (12): 1397-1402.
> Kapatai G, Murray P. Contribution ye Epstein-Barr virus kusvika ku molecular pathogenesis yeHodgkin lymphoma. Zvinyorwa zveKliniki Pathology. 2007; 60 (12): 1342-1349.
> Ok CY, Papathomas TG, Medeiros LJ, Young KH. EBV-positive diffuse yakakura B-cell lymphoma yevakwegura. Ropa. 2013; 122 (3): 328-340.
> Rockefeller University. Science News. Kutsvakurudza kutsva kunobatsira kutsanangura kuti nei kenza yeropa inouraya inowanzokonzera vana vane malaria.