Kunzwisisa Kusiyanisa muAfrica (Endemic) uye Sora yeBurkitt yaSporadic
Chii chinonzi Burkitt's lymphoma, chii chinokonzera, uye chinoshandiswa sei?
Overview
Burkitt's lymphoma (kana Burkitt Lymphoma) rudzi rusina kujairika rweNi-Hodgkin Lymphoma (NHL) . Burkitt's lymphoma inowanzobata vana. Icho chinotyisa zvikuru cheB-cell lymphoma iyo inowanzotanga uye inosanganisira zvikamu zvemuviri kunze kweropa . Pasinei nekunyanya kwayo kukura, Burkitt's lymphoma inowanzorapwa nemishonga yakawanda yemazuva ano.
Aina
Kune maviri mazamu akaenzana eBurkitt's lymphoma - izvo zvishoma nezvishoma uye zvakasiyana-siyana. Kune huwandu hwepamusoro hwechirwere ichi muEricatorial Africa, uye zvirwere munzvimbo ino inonzi inogara Burkitt's lymphoma. Zvirwere mune dzimwe nzvimbo dzenyika hazviwanzozivi uye zvinonzi sporadic Burkitt's lymphoma. Kunyange zvazvo iri chirwere chakafanana, maviri acho akasiyana nenzira dzakawanda.
Endemic (Africa) Burkitt's Lymphoma
MuEricatorial Africa, inenge hafu yevana vese kanzira yevana vanonzi Burkitt's lymphomas. Chirwere chacho chinosanganisira vana vakawanda kupfuura vanhu vakuru uye chakabatana neEppstein-Barr Virus (EBV) chirwere mumatambudziko 98%. Izvo zvine unhu hukuru hwekubatanidza rushaya, chimwe chinhu chinoparadzaniswa chisingawanzoitiki muBurkitt. Iyo inowanzobatanidza mimba.
Sporadic Burkitt's Lymphoma
Mhando yeBurkitt's lymphoma iyo inokanganisa nyika yose, kusanganisira Europe neAmerica ndiyo inoratidzika.
Pano zvakare, inonyanya kuva nechirwere muvana, kuva nechinokonzera chikamu chimwe chetatu chemaroto muvana muUnited States. Kubatana pakati peEpstein-Barr Virus (EBV) hakusi kwakasimba sekune dzakasiyana-siyana, asi uchapupu hwakananga hwehutachiona hweEBV huri mune mumwe wevashanu vashanu. Kupfurikidza nekubatanidzwa kwema-lymph nodes, ichi ndicho chibereko chinonyanya kugadziriswa mumapfumbamwe makumi mapfumbamwe evana.
Bhoora marora kubatanidzwa kunowanzopfuura pane zvakasiyana-siyana. Kupindira kwejaya hakuwanzoitiki.
Muchidimbu Maitiro Akafanana
Mhando mbiri dzisina kufanana dzeBurkitt's lymphoma dzinosanganisira:
- Rudzi rwepakati, rune zvinhu zveBurkitt's lymphoma uye rinopararira guru B-cell lymphoma .
- HIV- yakasanganiswa lymphoma, inobatanidza nehutachiona hweHIV.
Nhanho
Ichi chirwere chinogona kuputsika pasi nyore nyore muzvikamu zvina zvakasiyana (nhaurwa: izvi hazvina kukwana uye zvinogona kuitika pane dzimwe nguva.)
Nhanho I - Nharaunda I chirwere chinoreva kuti kenza iripo panzvimbo imwe chete mumuviri.
Nhanho II - Mutsara wechipiri II Burkitt's lymphomas inowanikwa mune imwe nzvimbo, asi nzvimbo mbiri idzi dziri kune rumwe rutivi rwechidimbu.
Chikamu III - Chirwere cheStage III chinowanikwa mumakirinikodhi kana zvimwe zvivako kumativi ose emudhafa.
Nhanho IV - Chirwere cheStage IV chinosanganisira lymphomas inowanikwa mumapfupa emafuta kana muuropi (central nervous system.)
Zvinokonzera uye Zviitiko Zvengozi
Sezvakataurwa pamusoro apa, Epstein-Barr inosanganiswa nehuwandu hwemhosva dzeBykitt's lymphoma, pamwe nedzimwe zvirwere zveporadic disease. Kuva nemunosuppppered is a factor factor, and in Africa, it is thought that malaria inogona kugadzirisa vana kuti vave panjodzi yeAppstein-Barr.
Kurapa
Burkitt's lymphoma inotyisa zvikuru, uye inowanzotyisidzira upenyu. Asi iyo ndeimwe yemhando dzakanyanya kuporesa ye lymphoma. Kuti uzvinzwisise izvi zvinobatsira kunzwisisa kuti chemotherapy inorwisa masero anonyanya kuparadzana. Kukwanisa kushandisa chemotherapy kwakagadzira zvimwe zvekurwisa lymphoma uye leukemias zvekare, iyo inoporesa uye inogona kurapwa panguva ino.
Nezvino zvinoshungurudza maitiro e chemotherapy anoshandisa zvinodhaka mukudhura kwepamusoro, uye nekuwanikwa kwezviyero zvitsva zvinotsigira vanhu panguva yekurapa kwakanyanya, iri lymphoma inorapwa mune varwere vakawanda.
Pasi rose inenge 80% yeavo vane zvirwere zvinowanikwa munzvimbo ino uye vanopfuura hafu yevana vane zvirwere zvakapararira vanoporesa. Nguva inotevera inodzoka zvakare haina kuonekwa.
Prognosis
Kufanirwa kweBurkitt's lymphoma muUnited States kwave kuchivandudzwa mumakore achangopfuura. Pakazosvika gore ra2002 uye 2008 makore mashanu ekupona akapararira kubva 71 kusvika 87% muvana pakati pekuberekwa nemakore makumi masere. Kune avo vane makore makumi maviri nemasere kusvika makumi matatu nemakumi mana (39) kusvika kune makumi matatu kusvika ku60%, uye kune varwere vakwegura vanopfuura makumi mana (40) kuponeswa kwehuwandu kwakavandudzwa zvakare. Kubvira panguva iyo kuwedzera kunatsiridza mukurapa, uyewo kutungamirirwa kwemigumisiro, zvakaitika.
Kutsungirira
Zvinogona kuva zvinotyisa kuti zvionekwe neine lymphoma, uye zvakatoipisisa kana iri mwana wako anoonekwa. Kurera mwana kunotora musha kutanga, asi iwe unoda rubatsiro rwako kupfuura kare pane ino. Paridza kune vamwe. Izvi zvinenge zvisingawanzoitiki, asi kuburikidza nehuwandu hwemagariro evanhu, pane inzvimbo inoshanda yeInternet yevanhu vanorwisana nechirwere ichi chaunogona kupinda mukutarisana ne 24/7 kutsigira. Lymphoma uye mapoka eukemia anogona kukupa rubatsiro rwekuwedzera munzira.
Sources
Coghill, A., naA. Hildesheim. Epstein-Barr HIV antibodies uye njodzi yekubatanidza malignancies: kuongorora mabhuku. American Journal of Epidemiology . 2014. 180 (7): 687-95.
Costa, L., Xavier, A., Wahlquist, A., uye E. Hill. Mitsva yekupona kwevarwere vane Burkitt lymphoma / leukemia muU.SA: kuongororwa kwemajeri 3691. Ropa . 121 (24): 4861-6.
Dunleavy, K., Pittaluga, S., Shovlin, M, et al. Kuderedza-kupisa kwehutano hwevanhu vakuru neBurkitt's lymphoma. The New England Journal of Medicine . 2013. 369 (20): 1915-25.
National Cancer Institute. PDQ Cancer Information Summaries. Mwana Wasiri Non-Hodgkin Lymphoma Treatment (PDQ). Health Professional Version. 09/29/15. http://www.ncbi.nlm.nih.gov/books/NBK65738/#CDR0000062808__1