Iyo epidermis ndiyo chikamu chekunze cheganda uye chakaumbwa nezvikamu zvishanu. Iyo yakagadziriswa corneum ndiyo yepamusoro yezvikamu zvishanu uye zvikuru inoshanda sechidziviriro.
Pamberi pakati pemakore ekuma1970, rondedum corneum yaifungidzirwa kuti yakasikwa muhupenyu, seplasitiki yakaonda inodzivirira kunyanya kushanda, pasi peganda. Mumakumi mashoma makumi emakore adarika, masayendisiti akawana kuti maitiro ezvakaberekwa nemakemikari e stratum corneum chaizvoizvo akaoma uye akaoma.
Kunzwisisa chimiro nekushanda kwesimbi inonzi corneum inokosha nokuti inokosha yekuve neganda rakanaka uye rakanaka. Iyi mifananidzo ichakutora iwe kuburikidza nezvinhu zvinokosha zve stratum corneum.
The Corneocyte
Imwe nyanzvi inonzi Corneum ine "brick uye matope" yakarongeka, uye "zvidhinha" mumufananidzo uyu mapuroteni akawanda anonzi corneocytes (ona mufananidzo). A corneocyte inoumbwa nemakumbo maduku e keratin mumatrikisi akarongeka. Iyo keratin inogona kuchengetedza mvura zhinji pakati pehutambo / tsvina. Iyo yakagadziriswa corneum inenge inenge 12 kusvika ku16 mapaundi e-corneocytes, uye imwe corneocyte inobata hurefu hwem 1 micrometer, zvichienderana nezvinhu zvinotevera: makore, nzvimbo inotaridzika, uye kusvibiswa kwemirasi yeUV .
Lamellar Bodies
Lamellar miviri inoumbwa mumakeratinocytes e stratum spinosum uye stratum granulosum. Apo keratinocyte inokura kune stratum corneum, enzyme inoshandura inviputi yekunze yemitumbi miviri, kusunungura mhando dze lipids inonzi mahvina mafuta acid uye ceramide.
Intercellular Lipids
Mafuta asina kuchena acids uye ceramid zvinosunungurwa kubva kumagetsi anounganidza pamwe chete mu stratum corneum kuti aite runyararo ruchiramba rwe lipids. Nokuti kune marudzi maviri e lipids, iyi yakatsetseka inotumidzwa semanirilar lipid bilayer. Iyi lipid bilayer inobata basa guru mukuchengetedza zvipingamupinyi zveganda uye inofananidzwa ne "dhaka" mumatope uye munondo wakafanana.
Envelope Inonzi Cornified
Korneocyte imwe neimwe yakakomberedzwa neproteine shell inonzi cell cell envelope. Sensupe envupeyo inonyanya kunyorwa nemaviri mapuroteni, loricrin uye involucrin. Izvo mapuroteni ane zvikwaniro zvakakura pakati peumwe, zvichiita kuti svipomu inopafu ive yakasvibiswa zvikuru yakagadziriswa ye corneocyte. Iyo miviri miviri yemashambapisi esero inorondedzerwa se "yakasimba" uye "yakaoma," inobva pakubatana kwe lamellar lipid bilayer pamwe neserovo envelope.
Envelope Envelope Lipids
Yakasungirirwa kumusero envelope ndiyo yakatenderera ka ceramide lipids iyo inodzokorora mvura. Nemhaka yokuti lamellar lipid bilayer inodzivirirawo mvura, mumasikorosi emvura anowanikwa pakati peesero envelope lipids uye lipine bilayer. Izvi zvinobatsira kuchengetedza mvura yakadzika mu stratum corneum nekuchera mvura mamolekemu, pane kuvabvumira kuti vapinde mumatanda ezasi epidermis.
Corneodesmosomes
I "rivets" iyo inobata corneocytes pamwe chete mapuroteni anozivikanwa anonzi corneodesmosomes. Izvo zvivako zvakare chikamu che "chibage" mu "brick uye mortar" kufanana. Corneodesmosomes ndiyo dzimba huru dzinofanira kuve dzakasvibiswa kuti ganda ridurwe mune imwe nzira inonzi dequamation.
Zvinhu Zvinowedzera Kuchinja (NMF)
Zvinhu zvinokonzerwa nemafuta zvinokonzera (NMF) inounganidza mishonga yakasanganiswa nemvura inowanikwa chete mu stratum corneum. Izvi zvinoumba zvinosvika 20 kusvika ku30 muzana yeoma yakaoma ye-corneocyte. NMF zvinokonzera mvura kubva mumhepo uye zvinosanganiswa nemvura yavo, zvichibvumira zvinyorwa zvekunze zve stratum corneum kuti igare hydrated pasinei nekusvika kune izvo zvinhu. Nemhaka yokuti nhengo dzeNMF dzakasvibiswa nemvura, dzinoshamiswa nyore nyore kubva kumasero ane mvura-inosaka kubvunzurudzwazve nemvura kunogadzikisa ganda. Iyo inenge yakakomberedzwa yakakomberedza corneocyte inobatsira kusimbisa korneocyte kudzivirira kurasikirwa kweNMF.
Desquamation Process
Izvo zvinoshandiswa pakutsvaga kana kuputika kwechirongwa chemakorome chinonyanya kuoma uye zvikamu zvezviitiko izvi zvinonzwisiswa zvakakwana. Zvinonyatsozivikanwa kuti mazana enzymes anokonzera marinome emakorome mune imwe nzira, asi chaiwo chaiwo emakemikari aya kana kuti anogadziriswa sei kuti utange utano hwekufemera hunozivikanwa. Mvura uye pH inobatsira zvikuru mumabasa ema enzyme.
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