Simba reAntiviral Agent
Ribavirin isiri yemishonga inorwisa mushonga inoshandiswa kuporesa utachiona husingaperi hutachiona hweH hepatitis C. Hazvinzwisisi zvachose kuti ribavirin asi, asi kazhinji izwi, rinopindira kuti hutachiona 'hukwanisa kudzokorora. Ribavirin inogamuchirwa neDain and Drug Administration (FDA) yekurapa hepatitis C uye iri kuWorld Health Organisation List of Mishonga inokosha.
Ribavirin inotengeswa pasi pezviverengero zvezita remazita akasiyana-siyana, kusanganisira Copegus, Rebetol, Ribasphere, uye RibaPak.
Drug Efficacy
Kusati kwasvika kuiswa kwehutano hwekuita zvakananga (DAAs) muna 2013-iyo inosanganisira zvinodhaka Sovaldi , Harvoni , Daklinza uye Viekira Pak , pakati pevamwe-nzira yakanakisisa yekurapa hepatitis C yaiva nekusanganiswa kwe ribavirin uye peginterferon . Iyo yeviri inorapwa inozivikanwa kuva nepamusoro-soro yemishonga yemigumisiro, imwe yadzo inogona kuva yakakura. Kunyange zvakadaro, chirwere ichi chakabatanidzwa chakakwanisa kuzadzikisa chirongwa che virologic (chirwere chemakiriniki chechirapa) mune anenge 50% emhosva.
Nhasi, neDAAs yekare, kushandiswa kwe ribavirin kwakaderera zvishoma nezvishoma kunyange zvazvo zvichiri kurongerwa mune dzimwe nzira dzokurapa, kunyanya nedzimwe mararamiro ( genotypes ) ehutachiona uye nevarwere vane chirwere chisina kukwana uye / kana chirwere chakakura chechiropa.
Drug Administration
Ribavirin inotorwa nemuromo, kazhinji mumasero maviri akatorwa maawa gumi nemaviri. Nhamba dzepamusoro dzinobva 800 mg kusvika 1,400 mg pazuva. Chiremba wako achaona kuti ribavirin yakawanda inoratidzei maererano nejenotype yehutachiona hwako, uremu hwako, uye hupi humwe mishonga ichagadziriswa mukurapa.
Kuchengetedzwa Kwemazuva Akasiyana
Zvimwe zvikamu zvinokonzera ribavirin zvichasiyana kubva kumunhu kusvika kune mumwe munhu, nevamwe vanhu vanotarisira zviitiko zvisingaiti zvirwere apo vamwe vanoona zviratidzo vanofunga kuti hazviregi. Maitiro akawandisa anowanzobatanidzwa ne peginterferon use ndeaya:
- Anemia (10% yemhosva)
- Headache
- Kunyangadza uye kuzvidya mwoyo
- Kuora mwoyo
- Kuora bvudzi (alopecia)
- Itchiness
- Kunyunyuta
- Joint pain (arthralgia)
- Uturu hwepamuviri ( myalgia )
- Anorexia
- Neutropenia
- Nausea uye kurutsa
- Fever
- Chills
- Kuneta
Varwere mukurapa vanowanzoreva nezveRuba Rage, inofanirwa nehuwandu hwekutsamwa uye nekukurumidza kushungurudzika. Kunyange zvazvo shoko racho rinoratidza chikonzero ichocho ribavirin, inowanzobatanidzwa ne peginterferon. Anodzvinyirira dzimwe nguva anorayirwa kuti aporese chirwere ichi, kunyanya kune varwere vane mamiriro ekurapa kwepfungwa.
Kuchengetedzwa Kwemari uye Kuwana
Nzira yakakwana yekurapa ye ribavirin inogona kuve yakadhura asi, zvinoshamisika, nedzimwe DHA DAss yechikoro, nguva yehutano yakapfupika kudarika kare. Munguva yakapfuura, inogona kutengesa mumadhora e $ 12,000 kuitira nguva yakazara. Nhasi, tarisira kuti inodhura yakawanda mu $ 2,500 yekodhi yevhiki-12 uye $ 5,000 kwemaawa gumi nemaviri.
Medicaid, Medicare, uye inshuwalisi yega yega inowanzovhara mari ye interferon apo chirwere che hepatitis C chinogamuchirwa.
Co-kubhadhara rubatsiro inogona kutsvaga kuburikidza nemugadziri wezvinodhaka kune vanokwanisa, uyewo zvirongwa zvekubatsira varwere (PAPs) yevashandi vasingabatsiri kana kuti vasina mari.
Treatment Contraindications
Ribavirin inonzi yakachengeteka kune vanhu vakawanda, asi pane vamwe vanhu vane mishonga inopesana. Ribavirin inofanira kudziviswa mumamiriro anotevera:
- Kana iwe uri nepamuviri. Kutsvakurudza kwekliniki kwakaratidza kuti ribavirin inogona kukonzera fetal birth defects . Vakadzi vanofanira kungorongedzerwa ribavirin kana chirwere chisati chaperekwa kutora chirwere chisina kunaka. Uyezve, maitiro maviri ekudzivirira kubata pamuviri anopa mazano kune vose mukadzi nomudzimai wake panguva yekurapa uye kwemwedzi mitanhatu mushure mokupera kwerapi.
- Kana iwe uchiyamwisa.
- Kana uine chirwere chepfungwa, chirwere chepfungwa chinenge chakaipa kana chirwere chakakura chechiropa.
- Kana uine autoimmune hepatitis.
Nguva dzose iva nechokwadi chokuti chiremba wako ane nhoroondo yako yehutano yakakwana, kusanganisira ruzivo pamusoro pezvimwe zvirwere zvisingaperi zvingave zvaunogona kuva nazvo (semuenzaniso, HIV , chirwere cheshuga) kana zvirongwa zvaunogona kuva nemimba.
Sources:
Genentech. "Copegus: Inonyanya kukoshesa Mashoko." Yakasvika musi waDecember 31, 2015.
Merck. "Rebetol: Inonyanya Kupa Mashoko." Yakasvika musi waDecember 31, 2015.