Kana iwe uchitora jekisi yevhiki nevhiki ye interferon, iwe unokwereta kuvonga chemistist. Izvi ndechokuti kunze kwekemikari ye pegylation iwe unoda kuvhara interferon kusvika katatu pavhiki. Muchidimbu, margylation inotora mushonga wako nyore uye chaizvoizvo inoita kuti zvive zvakanaka zviri nani.
Overview
Pegylated interferon, inowanzonzi peginterferon, inonzi chimiro yakashandurwa yakafanana ye-interferon inobata hepatitis C uye kashoma hepatitis B.
Musiyano pakati peeferferon uye peginterferon ndiyo PEG, iyo inomirira molecule inonzi polyethylene glycol. Icho chechidiki hachiiti chinhu chinorwisa utachiona. Asi nokuisungira iyo interferon (iyo inorwisana nehutachiona), interferon ichagara mumuviri (kunyanya ropa) yakareba kwenguva refu.
Izvi zvinobatsira varwere vane hepatitis vachitora interferon nokuti panzvimbo pokuda kuvhara interferon kusvika katatu pavhiki, kungoita kamwe chete kwevhiki rimwe nerimwe kunodiwa. Mukuwedzera, inobereka chiyero chepamusoro chekusimudzira virologic response .
Pane mabhii maviri e peginterferon, ayo anotengeswa sega Pegasys (anonziwo peginterferon alfa-2a) uye PegIntron (anonziwo peginterferon alfa-2b). Vose vane zviito zvakafanana zvemaprochemokinetic, ine zvishoma zvishoma pakati pezviviri.
Efficacy
Tisati tatanga kushandiswa zvakananga maitiro (DAAs) muna 2013-izvo zvinosanganisira zvinodhaka Sovaldi , Harvoni , Daklinza uye Viekira Pak , pakati pevamwe-nzira yakanakisisa yekurapa hepatitis C yaive nekubatanidzwa kwe peginterferon uye ribavirin .
Iyo yeviri inorapwa inozivikanwa kuva nepamusoro-soro yemishonga yemigumisiro, imwe yadzo inogona kuva yakakura. Kunyange zvakadaro, kurapwa kwakakwanisa kuwana hupenyu hwehupenyu hwehupenyu hwehupenyu hwehupenyu hwehupenyu hwehupenyu hwehupenyu hwehupenyu hwehutano hwehupenyu hwehupenyu hwehupenyu hwehutano hwehupenyu hwehutachiona hwehutachiona hwehutachiwana hwehutachiwana hunenge huri makumi mashanu muzana.
Nhasi, neDAAs itsva yeklasi, kushandiswa kwepinterterferon kwakanyangarika zvakanyanya, kunyange zvazvo dzimwe nguva ichiri kunyorwa mumamiriro ezvinhu epachirwere chepamusoro uye / kana kune varwere vakambotadza kurapwa.
Administration
Peginterferon inorapwa kamwechete kwevhiki. Iyo chaiyo inogona kusiyanisa kubva pane zvimwe zvinhu, kusanganisira genotype yehutachiona hwako , rudzi rwepiginterferon iwe uchange uri kushandisa, uye mishonga inotevera iri (s) iyo ichabatanidzwa pamwe chete nayo. Mukoti wako achakudzidzisa kuti unganyatsoita sei jekiseni, kazhinji kasi pasi (pasi peganda). Peginterferon inofanira kugara ichiri firiji, uye netafura haifaniri kushandiswa zvakare kana kugoverana.
Migumisiro Yechiri
Zvimwe zvikamu zvepeginterferon zvichasiyana kubva kumunhu kusvika kune mumwe munhu, nevamwe vanhu vanotarisira zvichangoita zvirwere zvisingaiti apo vamwe vanoona zviratidzo vanofunga kuti hazviregi. Maitiro akawandisa anowanzobatanidzwa ne peginterferon use ndeaya:
- Zviratidzo zvakadai semafutu (ane musoro, fever, chills, muscle aches)
- Kunyunyuta
- Kuora mwoyo uye mafungiro anochinja
- Kusvibiswa
- Nausea uye kurutsa
- Ganda rinoputika
- Kuneta zvakanyanya
- Kufirwa kwechido
- Kuonda
Varwere mukurapa vanowanzoreva nezveRuba Rage, chiitiko chinoratidzwa nehuwandu hwekutsamwa uye kamwe kamwe, dzimwe nguva kuputika kwepfungwa. Kunyange zvazvo shoko racho rinoratidza chikonzero ichocho ribavirin, inowanzobatanidzwa ne peginterferon. Anodzvinyirira dzimwe nguva anorayirwa kuti aporese chirwere chacho, kunyanya kune varwere vane mamiriro ezvinhu epfungwa asati avapo.
Mutengo
Nzira yakakwana yekurapa peginterferon inodhura asi zvinoshamisika, nevechikoro cheDAAs idzva, nguva yehutano inopfupika kudarika kare.
Medicaid, Medicare uye inshuwalisi yega yega inowanzovhara mari ye interferon apo chirwere che hepatitis C chinogamuchirwa. Co-kubhadhara rubatsiro inogona kutsvaga kuburikidza nemugadziri wezvinodhaka kune vanokwanisa, uyewo zvirongwa zvekubatsira varwere (PAPs) yevashandi vasingabatsiri kana kuti vasina mari.
Contraindications
Vamwe vanhu vane hepatitis C havafaniri kutora peginterferon. Izvi zvinosanganisira vanhu vane mamiriro anotevera:
- Yakawedzerwa chiropa, mwoyo, hono kana mapapu chirwere
- Zvimwe zvinetso zvekudzivirira
- Kunyanya kuora mwoyo kana mamwe mamiriro ekurapa
- Kuberekwa
- Kuberekwa
Nguva dzose iva nechokwadi chokuti chiremba wako ane nhoroondo yako yehutano yakakwana, kusanganisira ruzivo pamusoro pezvimwe zvirwere zvisingaperi zvingave zvaunogona kuva nazvo (semuenzaniso, HIV , chirwere cheshuga) kana zvirongwa zvaunogona kuva nemimba.
Sources:
Katzung, BG. Chechipiri uye Chipatara Pharmacology, 10e. New York, McGraw-Hill, 2007.
Brenner GM, Stevens, CW. Pharmacology, 2e. Philadelphia, Saunders Elsevier, 2006.
Genentech. "Pegasys: Zvinonyanya kukoshesa Mashoko . "
Merck. "PegIntron: Pfungwa huru yekunyora mashoko."