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Yose Chimvuramabwe, Harvoni!Vanotaura kuti haugoni kuisa mutengo wekutengesa pane utano hwako. Pamusoro pe $ 1000 piritsi, iyo itsva chishamiso-chirwere, Harvoni , zvichida inoratidza ichi aphorism.
Musi waOctober 10, 2014, FDA yakabvumira Harvoni yakatsvaga, iyo mishonga mitsva inobatwa neutachiona hwekushaya hepatitis C. Muna 2014, Harvoni yaiva mishonga yechitatu yakagamuchirwa neDDA yekurapa hepatitis C uye inozivikanwa nekubudirira kwayo kunoshamisa uye kamwe-a-day, oral oral administration.
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Chii Chinonzi Hepatitis C?Hepatitis C inonzi RNA virusi inokonzera hepatitis kana kuputika kwechiropa. Iye zvino, chirwere chechipatara C ndicho chinokonzera kupararira chinokonzera chirwere chisingaperi chechiropa muUnited States uye chinokanganisa 3 muzana yevanhu venyika. Hepatitis C inopararira neropa kana mishonga yeropa, uye vasati vauya kuongororwa kwakakwana kwehutachiona, vanhu vazhinji vakave nehutachiwana mushure mekuwedzerwa ropa. Pari zvino, vanhu vazhinji vanoita hepatitis C mushure mekugovana zvirairo pavanoshandisa zvinodhaka zvisina kukodzera.
Hepatitis C inoratidzika pathogen iyo inowanzokonzera chirwere chinorwara chinorwara. Panzvimbo pezvo, vanhu vazhinji vanoongororwa mushure mokupa zvirwere zvisingaperi - pamusana, makore gumi kusvika ku18 mushure mokunge mune utachiona. Uyezve, hutachiona nehutachiona hweH hepatitis C hunotungamirira kune zvirwere zvisingaperi muvanopfuura 85 muzana yeavo vane utachiona.
Hepatitis C inotaura zvakabatana ne hepatocytes kana masero eropa. Uyezve, hutachiona hunotama nokukurumidza uye nokudaro hunoita basa rakanaka rinopinda mumuviri wemuviri. Yenguva refu kana kusagadzikana kuputika kunotungamirira kuve necrosis yakawanda kana kufa kwemasero eropa uye cirrhosis. Chirwere chesvirus chinoratidzika semucheka mutsvuku yakasanganiswa nemagununu anonzi regenerative anopa chiropa chimiro che "lumpy" chaiye. Pakupedzisira, hepatitis C inotungamirira kukuderedza chiropa chinoshanda uye chiropa chisakundikana. Pakupedzisira, chirwere chisingaperi chine hepatitis C chinowedzera njodzi yehepatocellular carcinoma kana kenza yeropa. Nyaya, doro, kusvuta, kuneta uye kubatana-hutachiona nezvimwe zvirwere zvakadai seHIV (kana kunyange hepatitis B) hutachiona hutachiona hweH hepatitis C hwakaipa zvikuru.
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Kurapa Kusati Kwava Kuuya Kwezvinodhaka SeHarvoniGore rino rapfuura, FDA yave ichichema uye yakagamuchira 3 mishonga yakasiyana-siyana yekurapa hepatitis C: Harvoni nemadzimai emakemikari ayo Olysio (simeprevir) uye Sovaldi. Rimwe chete pane imwe nguva, zvakadaro, kurapwa kwemishonga chete kunotarisirwa pamararamiro e hepatitis C yaiva pegylated interferon yakabatana neRibavirin. Iyi sarudzo, kunyange ichishanda, haina kunyanya kushanda pakuita kuti virologic ("heal") igare yakasimba kupfuura Harvoni nehanzvadzi dzayo. Uyezve, interferon neRibavirin zvakaoma kutungamirira, kutora nguva yakareba kuti ipe uye ive nemigumisiro yakaipa kupfuura mishonga yakafanana neHarvoni.
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Saka Chii Chinonzi Harvoni?Harvoni ndeyekirasi yemishonga inozivikanwa seyakanyatsoita maitiro antiviral. Iyi mishonga inonyatsonyatsoshanda uye inoshanda pakurongedza kudzokorora kwehutachiona kupfuura pegylated interferon uye Ribavirin. Nyaya iyi, Harvoni yakaratidza kuti yakabudirira zvikuru kune vanhu vanorwisana nechirwere che hepatitis C. Uyezve, Harvoni inoshandiswa semubatanidzwa wepiritsi yemapiritsi uye ndiyo yekutanga mukirasi yayo inofanira kutarisirwa pasina pegylated interferon uye Ribavirin. Mumakiriniki ekuongororwa, vanopfuura 90 muzana yevatori vechikamu, vose pamwe uye vasina cirrhosis, avo vakagamuchira Harvoni vakawana virologic zvakasimba ("mushonga") mushure memavhiki gumi nemaviri ekurapa.
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Chii Chinonzi Harvoni Kwauri?Kana iwe kana mumwe munhu waunoziva ane hepatitis C, Harvoni chirwere chinokurudzira. Chokutanga, zvidzidzo zvinoratidza kuti kurapwa kwemishonga inoronga kuparadza mweya wehutachiona hweH hepatitis C kunogona kuwedzera chiropa chettology uye kudzivirira kudarika kuwedzerwa kweropa. Chechipiri, Harvoni, iyo inouya muhuwandu hwemapilisi, inobudirira uye inonyanya kutora kupfuura regimens inowanikwa pegylated interferon neRibavirin. Chechitatu, Harvoni yakaratidza kuti yakabudirira zvikuru kune vanhu vasingagoni kurwisana nehupatachi C kurapa (varwere vane cirrhosis kana genotype 1).
Pamusoro pekupedzisira, madhiragi akadai seHarvoni akagamuchira zvakawanda zvepepanhau kuti igare yakadhura. Rimwe remasvondo gumi nemaviri rinogona kubhadhara $ 94 500 kana kupfuura inopfuura $ 1 000 piritsi! (Kana, zvichienderana nekutarisa kwaunoita sei, mutengo weMercedes-Benz S550.) Uyezve, zvirongwa zvehurumende zveMedicaid dzakawanda zvine nguva yakaoma kuvhara mari yekurapa kwakadaro uye inoda kuti varwere vasangane zvakasimba zvechirongwa chekliniki gamuchira mvumo yapamberi.
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Pachiratidzo Chekupedzisira ...Zvinodhaka zvakadai seHarvoni zvave zvichiri kutora gomba rinodhura. Zvechokwadi vanobhadhara mari yakawanda asi hutano hwevanhu nehutano hwehupenyu hwehumwe huripo - hapana hutano hwakanaka kune avo vane chirwere chisingaperi chechipatara C - chinopfuura kupfuura imwe zana-yakawanda mari yekurapa. Kuvandudzwa kwezvinodhaka zvakadai seHarvoni chirwere chekurapa chaicho (uye ini handishandisi shoko iri zvishoma). Ichi chiremba chinopikira kubatsira vanhu vane zvirwere zvisingaiti kuti vadzivirire hupenyu hwose hwekusagadzikana, uye, hongu, mararamiro anokonzerwa nekusingaperi kunotora mhuri, shamwari neshamwari.
Sarudzo Sources
Dienstag JL. Chitsauko 304. Yakanaka Viral Hepatitis. Mu: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Harrison's Principles of Internal Medicine, 18e. New York, NY: McGraw-Hill; 2012. Yakasvika musi wa14 Gumiguru 2014.
Dienstag JL. Chitsauko 306. Chronic Hepatitis. Mu: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Harrison's Principles of Internal Medicine, 18e. New York, NY: McGraw-Hill; 2012. Yakasvika musi wa14 Gumiguru 2014.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm376449.htm. Yakasvika 10/14/2014.
"Simeprevir yekurapa utachiona hunokonzerwa nehepatitis C" naLaure Izquierdo et al kubva ku Pharmacogenetics uye uye Personalized Medicine yakabudiswa musi waAugust 14, 2014. Yakasvika 10/14/2014
"Kuwedzera Kurapwa Kwechipatara C" neChina Young et et al de Gut Liver rakabudiswa munaSeptember 2014. Yakasvika 10/14/2014.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164256 /
Ryan KJ, Ray C. Chitsauko 13. Hepatitis Viruses. Mu: Ryan KJ, Ray C. eds. Sherris Medical Microbiology, 5e. New York, NY: McGraw-Hill; 2010. Yakasvika musi wa14 Gumiguru 2014.