Piritsi yepabonde Flibanserin Inonyoroveswa muDhe Drama
Kune vanovhiringidza, flibanserin, pirinki yepinki inotarisana nevakadzi libido uye yakaitwa neSprout Pharmaceuticals, inongova imwewo muenzaniso wezvirwere mutezo. Zvirwere zvinoreva maitiro emakambani ekurapa uye vamwe "kuvhiringidza" zvinhu zvehutano hwevanhu kuitira kuti vaite buck. Semuenzaniso, halitosis kana mweya wakaipa wakava mamiriro ezvinhu aida kurapwa mushure mokunge Listerine yakagadzirirwa "kurapa".
Zvisinei, kune vatsigiri varo, chido chepabonde chepabonde / arousal disorder chirwere chaicho chaizvo, uye flibanserin inogona kubatsira. Ava vatsigiri vanotaura kudzvinyirirwa kunokonzerwa nekutapudza kana kusina zvekuita zvepabonde.
Chii Chiri Chikadzi Kuda Zvepabonde / Arousal Disorder?
Kufarira zvepabonde zvepabonde / arousal disorder kunoreva kuderedzwa kana kusavapo kwekuita zvepabonde kune mukadzi anotora mwedzi mitanhatu kana kupfuura uye anokonzera kushushikana kana matambudziko. Uyezve, kusafarira kwakadaro hakubatsiri kune rimwe chirwere (funga nezvekurwara cheshuga kana kuora mwoyo) kana zvinodhaka (funga zvinoderedza kuzvidzora). Zvakakosha kuti kurasikirwa kwechido chepabonde kunokonzera kushushikana kana kuoma nekuti, kana zvisina kudaro, hachisi chaicho chinetso. Mushure mezvose, vanhu vazhinji vane hanya nekugara kwenguva refu mune zvepabonde izvo hazvisi kukonzera matambudziko evanhu, uye izvi zvakanaka.
Vanotsvakurudza vanofunga kuti mukadzi anofarira zvepabonde / arousal disorder inosanganisira yakaoma uropi hutachiona hunotarisa mubayiro wokugadzirisa.
Kunyanya, izvi zvinokanganisa frontostriatal nzira uye neuronal zviratidzo zve insula, amygdala, hypothalamus uye ventral striatum. Madzimai vane rudo rwakadaro rwepabonde uye nharo dzekumutsa, zvekuita zvepabonde nemafaro zvinoshandiswa zvakanyanya. Zvinyorwa, mubhadharo wekubatsira kushandiswa mune zvimwe zvirwere zvepfungwa zvinosanganisira kuora mwoyo, schizophrenia, kushandisa zvinodhaka, kuora mwoyo, zvinetso zvekudya nezvimwe zvinetso zvepabonde.
Zvinofadza kuti vatsvakurudzi vakaona kuchinja kweMRI inoshanda inoratidza macrocircuit anomalies inokonzerwa nehutano hwepabonde / kukonzera matambudziko. Semuenzaniso, vakadzi vanorwara vane chirwere ichi chinoratidzira kushandiswa kwemaitiro mumakirini emakirini uye eratalatal.
Flibanserin Inoshanda Sei?
Izvo zvakaoma chaizvo (zvisingaiti) kuti masayendisiti aenzanise maitiro emhando yeurourotransmitter munzvimbo dzakasiyana dzeuropi. Zvisinei, achishandisa michina ye microdialysis uye nodes mukati mehutano hwehuropi, vatsvakurudzi vanotaura kuti flibanserin inowedzera kusunungurwa kwezvose dopamine uye norepinephrine uye inoderedza kusunungurwa kwe serotonin kuvakadzi vane kuderedza kufarira zvepabonde nechido. Kunyanya, flibanserin inogona kusiyanisa pakati pe-serotonin receptors uye inokurudzira serotonin 5HT1A receptors ichidzivirira serotonin 5HT2A zvakagadziriswa mu prefrontal cortex zvichiwedzera kubudiswa kwepasi kwe dopamine uye norepinephrine. Sezviri pachena, izvi zvinosangana neurotransmitter migumisiro inobatsira zviri nani kutonga mubayiro nekugadzirisa nekuwedzera vakadzi libido.
Pamusoro pechinyorwa chino, flibanserin inoshanda pamaurotransmitter, kwete mahomoni. Kunyange zvazvo mahomoni akaonekwa kuti anobatsira pakuwedzera libido, zvinokonzera kuipa zvinoita kuti zvivewo zvine ngozi sekurapa.
Uyezve, flibanserin haisi "yevakadzi Viagra." Viagra inoshanda nekuwedzerwa kweropa kunopfuurira kumakemikari uchishandisa nzira yakasiyana zvakasiyana uye inopindira nzvimbo yakasiyana yezviito (maritals vs. brain).
Migumisiro kubva kumakirini maviri emakiriniki anonzi BEGONIA uye DAISY (ah, mazita emaruva ... kuti akanaka sei) anoratidza kuti flibanserin inogona kuwedzera vakadzi libido. Yakabatanidzwa, iyi miedzo yakarongedzwa uye ye-placebo-yakarongedzwa yakaongororwa vakadzi 3548 vane chido chepabonde nekumutsa dambudziko. Pashure pemavhiki makumi maviri nemasere ekurapa ne 100 mg flibanserin, zviitiko zvepabonde zvinogutsa, chido chepabonde , uye kushungurudzwa kunokonzerwa nechishuvo chepabonde chepabonde chakayerwa vachishandisa mibvunzo yakasiyana-siyana (inotenderera).
Vatsvakurudzi vakacherechedza kuti pane vatori vechikamu vanotora flibanserin-kana vachienzanisa nevaya vanotora placebo-pane kuwedzera kwehutano hwehutano hunogutsa nehuwandu hwechido chepabonde uye kuderera kwekutambudzika kunokonzerwa nekuderera kwepabonde.
Zviitiko zvakakomba zvakanyanya mumatambudziko aya zvakaitika mune zvishoma pane imwechete yezana yevatori vechikamu, uye hapana chimwe chezviitiko zvakakomba zvakakonzerwa ne flibanserin kurapa pachake. Zvishoma nezvigaro zvakakomba zvinokonzera kusanganisira ucheche, kusuruvara, kuneta, uye kurara (zvakajairika).
Chimwe chiitiko chinotarisa uye chinokonzerwa ne-placebo-chengeteredzwa chinonzi SNOWDROP (Ndiri kuona chimiro, pano ... rimwe zita rehuva!), Rakarongedza vakadzi 949 postmenopausal vane chido chepabonde chekuita zvepabonde / arousal disorder (technically hypoactive sex sexual disorder-DSM-IV- TR iyo yave ichigadziriswa kuita zvepabonde / arousal disorder mu DSM-5). Zvakawanda seimwe mimwe miedzo, zvigumisiro zvinoratidza kuti flibanserin inovandudza chido chepabonde, huwandu hunogutsa zviitiko zvepabonde uye inoderedza kushungurudzwa kwepabonde zvose zvichikonzera zvishoma zvingava nemigumisiro yakaipa. Kunyanya, 37,6 muzana yevakadzi pa flibanserin kusvika 28.0 muzana yevakadzi vanotora placebo vakataura kuti vanogutsa zviitiko zvepabonde.
Kunyangwe mune zvimwe zvezviongorori vatsvakurudzi vakaedza kuisa vatori vechikamu vachitora mishonga yekurwisa zvinodhaka, antihypertensives, triptans uye zvimwe zvipfeko, chimwe chimwe chinopfurikidza chezviongororwa izvi ndechekuenzanisa kusarura. Mune mamwe mazwi, nokuti nyaya dzine chokuita nekuita zvepabonde uye chido zvakapararira uye zvinopinda marudzi ose evakadzi, zvakanga zvakaoma kuongorora kana flibanserin inoshanda kune munhu wose.
Kutaura nezvekunetseka pamusoro pekuchengetedza uye kubudirira, FDA yakaramba kubvumira flibanserin kaviri-kukanganisa izvo muiti wayo, Sprout Pharmaceuticals, uye vamwe vanotora. Kubva pane kurapwa kwezvoutano, ini ndinonyatsonzwisisana nezvinetso zve FDA. Mushure mezvose, zvishandiso zveflibanserin zvine maurotransmitter anoverengeka nekufunga kuti vazhinji vevakadzi vanozotora mushonga uyu zvakare vari kutora mamwe madhiragi anowedzera kuchinja maitiro eurotransmitter - sevanorwisa mweya uye anxiolytics - zvakanakisisa kutora chirevo.
Mhedziso
Vanhu vazhinji vakatendeseka havazivi chekufunga nezve flibanserin. Kune rumwe rutivi, vanhu vazhinji vanofungidzirwa nezvekambani yemishonga uye vavariro dzavo uye vanofanotaura kuti kana zvichigamuchirwa, flibanserin inogona kuderedzwa kune vamwe vakadzi vakaita sevaya vasingaoni dambudziko rinosangana nehurombo hwechido chepabonde kana kumutsa. Pane imwe nhoroondo yakabatana, zvinhu zvose pamusoro pekutsvaga kweSprout kweFlibanserin kunoshungurudza kushandiswa kusanganisira mapiritsi emicheka mutsvuku uye maruva-monikered makiriniki ekuedza. Kune rumwe rutivi, zvakaoma kunzwisisa migumisiro yeFlibanserin kunze kwekuti iwe uri mukadzi anoshandisa mushonga.
Sources:
Chinyorwa chakanzi "Efficacy uye kuchengetedzwa kweflibanserin mumadzimai emasopaopausal ane chishuvo chekuita zvepabonde chishuwo chekuita zvepabonde: zviitiko zveSNOWDROP nyeedzo" naJA Simon nevanyori vanyori vakabudiswa muMenopause: The Journal of The North American Menopause Society yakabudiswa muna 2013.
Chinyorwa chakanzi "Mushonga wekuita kwe flibanserin, serotonin agonist uye mushori (Multisactional agonist) uye mushori (MSAA), mukunyengera kwechishuwo chekuita zvepabonde" neS SM Stahl rakabudiswa muNCS Spectrums muna 2015.
Chinyorwa chinonzi "Kuvandudza tarisiro yekurapa chishuvo chekuita zvepabonde chishuwo chekuita zvepabonde (HSDD): chimiro chekusimudzira flibanserin" naJ Thorp, Jr, uye vanyori vanyori kubva kuBJOG rakabudiswa muna 2014.