Kunzwisisa Izvi Hepatitis C "Mushonga"
SVR yakasimba yehutachiona (SVR ) yevanhu vane hutachiona hweH hepatitis C zvinongoreva kuti hakuna humwe hutachiona hweH hepatitis C (HCV) muropa ravo mushure mokunge vatambira chirwere cheHepatitis C. SVR ndiyo chinangwa chikuru cheHCV chirwere uye, muzviitiko zvakawanda, inogona kujekeswa kuchipatara se "mushonga" kana HCV yehutachiona hwemutoro inoramba isingaonekwi masvondo makumi mana mushure mekupera kwekurapa.
Munenge mamiriro ezvinhu ose, vanhu vane SVR yemavhiki makumi maviri nemasere havanzwisisiki nehutachiona hwemagetsi (kureva, kudzoka kwehutachiona). Kazhinji tsvakurudzo inoratidza kuti kuwedzera kwehuwandu hunoita sepashoma se1% kusvika 2 muzviitiko zvakadaro.
Kusarura SVR uye Zvimwe Mhinduro dzeVilologic
Kutevera kutangwa kwehepatitis C therapy, ropa rinowedzwa kuti rienzane nehutachiona. Icho chinangwa chikuru ndekuwana hutachiona hwehutachiona husingaoneki. "Hazvioneki," munyaya iyi, hazvireve kuti zero kana kusakwana kwekuita kwehutachiona mumuviri; asi, rinotsanangurwa sekusina hutachiwana hunowanikwa muropa uchishandisa unyanzvi hwokuongorora.
Chikamu chimwe nechimwe chekupindura chinopiwa chikamu, uye dzimwe nhanho dzinobatanidza nehukuru kana hudiki hwehutano hwokubudirira. Tarisa chati iri, pasi apa.
| Nguva | Meaning | Tsanangudzo | Prognosis |
| RVR | Rapid viral response | Imwe musingaoneki wehutachiona mushure mavhiki mana ekurapa | Kazhinji kazhinji inogona kuwana SVR |
| RVR | Yakawedzerwa nekukurumidza kwehutachiona mhinduro | Iko kusingaoneki kwehutachiona hwemavhesi pavhiki 12, inotevera yekutanga RVR | Kazhinji kazhinji inogona kuwana SVR |
| EVR | Kutanga kwehutachiona hwekutanga | Iko kusingaoneki kwehutachiona hwehutachiwana kana kuti 99 kubva muzana kuderedzwa kwehutachiona hwemaawa nevhiki 12 | Kukundikana kusvika kuEVR kuwirirana kusvika pasi pe4 muzana yekana yekuwana SVR |
| ETR | Mugumo wemhinduro yekurapa | Iko kusingaoneki kwehutachiona hwehutachiwana hunopera pakupera kwesvondo 12 | Hazvibatsiri pakufanotaura mberi kwemigumisiro yehutano |
| Partial responder | Inokwanisa kuzadzikisa EVR asi haikwanise kuchengeta musingaoneki wehutachiona hwemaawa masere makumi maviri pashure pekurapa kupera | Inofungidzirwa kurapa kukanganisa | |
| Null mhinduro | Haikwanisi kuwana EVR nevhiki 12 | Mishonga inowanzoguma kana EVR isingagoneki nevhiki 12 | |
| SVR | Mhinduro yehutachiona yakasimudzirwa | Inokwanisa kuchengetedza utachiona husingaoneki hwemavhesi gumi nemaviri (SVR-12) uye masvondo makumi maviri nemaviri (SVR-24) mushure mokupera kwerapi | SVR-24 inoonekwa se "mushonga," uye varwere vane SVR-12 vanowanzokwanisa kuwana SVR-24 |
Kuwedzera mikana yako yekuwana SVR
Chimwe chezvinhu zvakakosha zveSVR kubudirira nguva, uye kurapwa kwepakutanga kunobatsira varwere kupfuura kurapwa kwakanonoka. Nokurapa utachiona hwako usati hwave uine kuora kwechiropa (kana, zvakakodzera, chero kukanganisa), iwe kazhinji unayo mukana wakanaka wekuwana chirwere chekliniki yeHCV.
Uyezve, itsva-kirasi-inoshanda-maitiro antivirals (DAAs) yakagadzirisa zvakanyanya kurapwa kwemitengo yevanhu vane chirwere chisingaperi cheHCV. Kunyange kune vanhu vane chikwereti chepirhosis , avo vaimbova nekana 50/50 mukana wekubudirira kwehutano, SVR mitsva yakakwira zvishoma nezvishoma kusvika kuzana 95 nepamusoro mune dzakawanda zvezviitiko izvi.
Chikamu III miedzo yevanhu vakafungidzira kuti kurapa kwakadai kunotevera kwevachangobva kutapwa (naïve) uye varwere vaimbobata (vane ruzivo) vane HCV:
- Daklinza (daclatasvir) akashandiswa naSovaldi: 98 muzana naive uye 58 muzana vane ruzivo rwechirwere
- Harvoni (sofusbuvir + ledipasvir) : 99 muzana naïve uye 94 muzana vanoziva
- Sovaldi ( sofosbuvir ) yakashandiswa pamwe ne ribavirin + peginterferon kana ribavirin chete: 82 kusvika 92 muzana
- Technivie (ombitasvir + paritaprevir + ritonavir) : 99 muzana neaive uye vane ruzivo
- Viekira Pak (ombitasvir + paritaprevir + ritonavir yakapetwa ne dasabuvir) : 95 muzana neaive uye vane ruzivo
- Olysio (simeprevir) inoshandiswa ne ribavirin + peginterferon: 80 kusvika ku 85 muzana naïve
- Zepatier (grazoprevir + elbasvir) inoshandiswa kana kuti pasina ribavirin: 95 muzana naïve uye vane ruzivo
Zvisingakwanisi Kubudirira SVR Zvinoreva
Kunyange zvazvo chinangwa cheHCV kurapwa ndechokubvisa zvachose utachiona uye kubvumira munhu kurarama hutano hwakanaka, hutachiita husina hutachiona, murwere haafaniri kuora mwoyo kana iye asingagoni kuzadzisa zvinangwa izvi.
Kunyange kana iwe uine mhinduro shomanana, zvidzidzo zvakaratidza kuti zvinobatsira chiropa zvinogona kunge zvakakomba-kwete kungotadzisa nguva yechirwere asi mune dzimwe nguva kuchinja frosis, kunyange kune avo vane chirwere chakakomba chechiropa.
Kana iwe ukakundikana yako yekutanga kana kuti yechipiri yemishonga, tora nguva yekucherechedza zviitiko zvako zveropa nechiremba wako. Kana iwe uchinzwa kuti wakagadzirira kuedza zvekare, chiremba wako anogona kuita miedzo yakawanda kuti aone kuti mishonga ipi inogona kukupa iwe mukana wakanaka wekuwana SVR kubudirira.
Kutsungirira Hepatitis C
Usarega kutapukirwa kwehepatitis C kunoita kuti unzwe wakasurukirwa. Kune rubatsiro runowanikwa.
Kunze kwekukumbira shamwari dzako nemhuri yako kuti ikubatsire munguva yerwendo rwako, unogona kuwana nyaradzo yekubatana nehutano hwehutachiona hweH hepatitis C kana kuti chirwere chisingaperi chine hepatitis boka. Uyezve, kudzidza zvakawanda nezvekugara kwenguva refu kwechipatara kunogona kuita kuti unzwe zviri nani uye zvinogona kuvandudza kurapwa kwako.
> Sources:
> Chopra, S., uye D. Muir. Kurapa Kunokonzerwa Nehupenyu Husingaperi Hwepatitis C Virus Genotype 1. UpToDate . Updated 09/14/16.
> Kattakuzhy, S., Wilson, E., Sidharthan, S. et al. Mienzaniso yakasimudzirwa yakasimudzirwa yeVrologic With 6-Week Combination Directly Acting Anti-Hepatitis C Virus Therapy in Patients With Advanced Liver Disease. Clinical Infectious Disease . 2016. 62 (4): 440-7.
> Kattakuzhy, S., Wilson, E., Sidarthan, S. et al. Kuchinja Kwekuramba Kushamwaridzana Nevamwe Vari Mukati Pakutanga Kurapa, Viral Failure, uye Kuburikidza Nokurongeka Zvakananga Antiviral Therapy (NIH KUTAURWA KUTAURA). AASLD Chiver Musangano; 2015; abstract 220.
> Smith-Palmer, J., Cerri, K., uye W. Valentine. Kubudirira Kutsigirwa Kwechirwere chechirologic muHepatitis C: Ongororo Yakagadziriswa yeKliniki, Ihupfumi nehutano hweHupenyu Mazano. BMC Inotapukira Matwere . 2015. 15:19.